From Wikipedia, the free encyclopedia
Protein-coding gene in the species Homo sapiens
Myosin phosphatase Rho-interacting protein is an
enzyme that in humans is encoded by the MPRIP
gene .
[5]
[6]
Interactions
M-RIP has been shown to
interact with
RHOA .
[7]
References
^
a
b
c
GRCh38: Ensembl release 89: ENSG00000133030 –
Ensembl , May 2017
^
a
b
c
GRCm38: Ensembl release 89: ENSMUSG00000005417 –
Ensembl , May 2017
^
"Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^
"Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^ Nagase T, Ishikawa K, Suyama M, Kikuno R, Hirosawa M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (May 1999).
"Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro" . DNA Res . 5 (6): 355–64.
doi :
10.1093/dnares/5.6.355 .
PMID
10048485 .
^
"Entrez Gene: M-RIP myosin phosphatase-Rho interacting protein" .
^ Gebbink MF, Kranenburg O, Poland M, van Horck FP, Houssa B, Moolenaar WH (Jun 1997).
"Identification of a novel, putative Rho-specific GDP/GTP exchange factor and a RhoA-binding protein: control of neuronal morphology" . J. Cell Biol . 137 (7): 1603–13.
doi :
10.1083/jcb.137.7.1603 .
PMC
2137826 .
PMID
9199174 .
Further reading
Bonaldo MF, Lennon G, Soares MB (1997).
"Normalization and subtraction: two approaches to facilitate gene discovery" . Genome Res . 6 (9): 791–806.
doi :
10.1101/gr.6.9.791 .
PMID
8889548 .
Gebbink MF, Kranenburg O, Poland M, van Horck FP, Houssa B, Moolenaar WH (1997).
"Identification of a novel, putative Rho-specific GDP/GTP exchange factor and a RhoA-binding protein: control of neuronal morphology" . J. Cell Biol . 137 (7): 1603–13.
doi :
10.1083/jcb.137.7.1603 .
PMC
2137826 .
PMID
9199174 .
Surks HK, Richards CT, Mendelsohn ME (2004).
"Myosin phosphatase-Rho interacting protein. A new member of the myosin phosphatase complex that directly binds RhoA" . J. Biol. Chem . 278 (51): 51484–93.
doi :
10.1074/jbc.M305622200 .
PMID
14506264 .
Bouwmeester T, Bauch A, Ruffner H, Angrand PO, Bergamini G, Croughton K, Cruciat C, Eberhard D, Gagneur J, Ghidelli S, Hopf C, Huhse B, Mangano R, Michon AM, Schirle M, Schlegl J, Schwab M, Stein MA, Bauer A, Casari G, Drewes G, Gavin AC, Jackson DB, Joberty G, Neubauer G, Rick J, Kuster B, Superti-Furga G (2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway". Nat. Cell Biol . 6 (2): 97–105.
doi :
10.1038/ncb1086 .
PMID
14743216 .
S2CID
11683986 .
Jin J, Smith FD, Stark C, Wells CD, Fawcett JP, Kulkarni S, Metalnikov P, O'Donnell P, Taylor P, Taylor L, Zougman A, Woodgett JR, Langeberg LK, Scott JD, Pawson T (2004).
"Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization" . Curr. Biol . 14 (16): 1436–50.
Bibcode :
2004CBio...14.1436J .
doi :
10.1016/j.cub.2004.07.051 .
PMID
15324660 .
S2CID
2371325 .
Mulder J, Ariaens A, van den Boomen D, Moolenaar WH (2005).
"p116Rip targets myosin phosphatase to the actin cytoskeleton and is essential for RhoA/ROCK-regulated neuritogenesis" . Mol. Biol. Cell . 15 (12): 5516–27.
doi :
10.1091/mbc.E04-04-0275 .
PMC
532030 .
PMID
15469989 .
Koga Y, Ikebe M (2005).
"p116Rip decreases myosin II phosphorylation by activating myosin light chain phosphatase and by inactivating RhoA" . J. Biol. Chem . 280 (6): 4983–91.
doi :
10.1074/jbc.M410909200 .
PMID
15545284 .
Benzinger A, Muster N, Koch HB, Yates JR, Hermeking H (2005).
"Targeted proteomic analysis of 14-3-3 sigma, a p53 effector commonly silenced in cancer" . Mol. Cell. Proteomics . 4 (6): 785–95.
doi :
10.1074/mcp.M500021-MCP200 .
PMID
15778465 .
Surks HK, Riddick N, Ohtani K (2006).
"M-RIP targets myosin phosphatase to stress fibers to regulate myosin light chain phosphorylation in vascular smooth muscle cells" . J. Biol. Chem . 280 (52): 42543–51.
doi :
10.1074/jbc.M506863200 .
PMID
16257966 .
Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (2006).
"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks" . Cell . 127 (3): 635–48.
doi :
10.1016/j.cell.2006.09.026 .
PMID
17081983 .
S2CID
7827573 .
Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007).
"Large-scale mapping of human protein-protein interactions by mass spectrometry" . Mol. Syst. Biol . 3 (1): 89.
doi :
10.1038/msb4100134 .
PMC
1847948 .
PMID
17353931 .