Lynne Marie Musgrave Angerer | |
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Born | December 7, 1944 |
Died | March 3, 2013 |
Alma mater | Ohio State University (B. S., 1966) (M.S., 1967) Johns Hopkins University (Ph. D., 1973) |
Known for | sea urchin in situ hybridization |
Spouse | Robert C. Angerer |
Children | Jennifer Lynne Angerer & Mark Alan Angerer |
Scientific career | |
Fields | Developmental Biologist |
Institutions | University of Rochester |
Thesis | Physical and chemical studies on the structure of whole and selectively deproteinized deoxyribonucleoproteins from calf thymus (1973) |
Lynne Marie Musgrave Angerer (December 7, 1944 – March 30, 2013) [1] was a developmental biologist most notable for research with sea urchin development during her time spent as Head of the Developmental Mechanisms (NIDCR) at the National Institutes of Health (NIH). [2] She worked at the University of Rochester and received her PhD at Johns Hopkins University studying chromatin structures. [2]
Lynne Angerer is best known for her research of determining the cellular fates of cells in sea urchins. With her sea urchin work she was able to develop a method of in situ hybridization through the use of RNA probes. [2] Another breakthrough developed by Angerer was the use of morpholino-substituted antisense oligonucleotides in the sea urchin to knock down and interfere with individual genes. [2] This is achieved through the usual configuration of expression a ribosome attached with a phosphodiester bond being replaced by morpholine ring attached with a phosphodiamidate linkage; this process prevents the ribosome from attaching and this specific gene is not expressed. [3] Both of these procedures she developed are now the industry standard.
Angerer also discovered that specific neurons derive from a unique tissue in an organism's gut, this finding challenged the central dogma which previously stated that neurons only derived from embryonic tissues. [4] Angerer and her husband Robert played a major role in the sequencing the sea urchin genome for the first time. The sequences that she found are used widely in sea urchin studies. [2]