In 1966 he moved into cancer-related research, specifically at
National Institutes of Health and later the
National Cancer Institute where he turned his interest in visual pattern recognition to
medical imaging applications.[1][9] He also worked on efficient algorithms for screening chemical compounds for studying chemical carcinogenesis.[1][10][11][12][13][14] His work on models of clustering for chemical compounds was pronounced a "milestone" by the Developmental Therapeutics Program of the National Cancer Institute, for "revolutioniz[ing] the selection of compounds of interest by measuring the novelty of a chemical structure by comparing it to known compounds."[15]
^"Artificial Intelligence Project – RLE and MIT Computation Center Memo 18 – Some results from a pattern recognition program using LISP", undated memo,
[1]
^Hodes, L. "Machine Processing of Line Drawings", M.I.T. Lincoln Laboratory Report, 54G-0028 March 1961
^"Perspectives in Deductive Databases",
Jack Minker, The Journal of Logic Programming
v.5, #1, March 1988, pages 33–60
[2]
^Foundations of disjunctive logic programming (1992), Jorge Lobo, Jack Minker, Arcot Rajasekar, MIT Press,
ISBN0-262-12165-4, p.19
[3]
^"Substructure Search with Queries of Varying Specificity", Alfred Feldman, Louis Hodes, J. Chem. Inf. Comput. Sci., 1979, 19 (3), pp 125–129,
doi:
10.1021/ci60019a003[5]
^"A two-component approach to predicting antitumor activity from chemical structure in large-scale screening", Louis Hodes, J. Med. Chem., 1986, 29 (11), pp 2207–2212,
doi:
10.1021/jm00161a013[6]
^"Clustering a large number of compounds. 1. Establishing the method on an initial sample", Louis Hodes, J. Chem. Inf. Comput. Sci., 1989, 29 (2), pp 66–71,
doi:
10.1021/ci00062a004[7]
^"Selection of molecular fragment features for structure-activity studies in antitumor screening", Louis Hodes, J. Chem. Inf. Comput. Sci., 1981, 21 (3), pp 132–136,
doi:
10.1021/ci00031a004[8]
^"Computer-aided selection of compounds for antitumor screening: validation of a statistical-heuristic method", Louis Hodes, J. Chem. Inf. Comput. Sci., 1981, 21 (3), pp 128–132,
doi:
10.1021/ci00031a003[9]
^"Milestone (1981): Hodes model for ranking small molecule structures (sic)", www.cancer.gov
[10]