Below is a list of notable people born in Prilep, North Macedonia or its surroundings:
- Ipče Ahmedovski, singer
- Gregory Akindynos, theologian
- Ezgjan Alioski, football player
- Metodija Andonov-Čento, first president of ASNOM and of the Socialist Republic of Macedonia
- George Atanasoski, politician and founder of several companies
- Atanas Badev, composer
- Dobrila Grasheska, singer
- Marko Cepenkov, folklorist
- Haris Hajradinović, football player
- Blaže Koneski, poet, writer, literary translator, linguistic scholar (codification of standard Macedonian)
- Prince Marko, Macedonian king
- Ilčo Naumoski, football player
- Petar Naumoski, former basketball player and current politician
- Mile Nedelkoski, writer
- Jane Nikolovski, football goalkeeper
- Dositej Novaković, Orthodox bishop
- Ali Fethi Okyar, Turkish diplomat and politician
- Elena Petreska, pop singer
- Gjorče Petrov, leader of the Internal Macedonian-Adrianople Revolutionary Organization (IMARO)
- Petar Popović, Serbian architect
- Toše Proeski, Macedonian music megastar
- Goce Sedloski, football player, defender
- Gligor Sokolović, Chetnik vojvoda
- Mihail Solunov, journalist and monk
- Vlatko Stefanovski, ethno-rock jazz fusion guitar player
- Dimitar Talev, writer
- Elena Velevska, turbo folk and popular music singer