This is a list of cutaneous conditions associated with internal malignancy; skin markers of internal cancer. [1] It does not include skin infections associated with cancer or cancers that spread to skin. [1] Some have stronger associations with cancers than others. [2]
| Cutaneous condition | Internal malignancy |
|---|---|
| Erythema gyratum repens | Lung cancer |
| Hypertrichosis lanuginosa acquisita | Lung cancer |
| Paraneoplastic pemphigus |
Non-Hodgkin lymphoma
[nb 1] Chronic lymphocytic leukemia Castleman's disease [nb 1] Sarcoma Thymoma |
| Tripe palms | Lung cancer |
| Tripe palms with acanthosis nigricans | Stomach cancer |
| Pityriasis rotunda | Hepatocellular carcinoma |
| Migratory thrombophlebitis | Pancreatic adenocarcinoma |
| Leser–Trélat sign | Gastrointestinal adenocarcinoma |
| Acquired ichthyosis | Hodgkin disease |
| Pityriasis rotunda | Hepatocellular carcinoma |
| Paraneoplastic pigmentation | Small cell bronchial carcinoma |
| Acrokeratosis paraneoplastica | Squamous cell carcinoma of the upper respiratory or gastrointestinal
tracts |
| Necrolytic migratory erythema | Glucagon secreting
pancreatic islet cell adenoma |
| Dermatomyositis | Lung cancer in men, breast and gynaecological tumours in women and colorectal cancers in both sexes |
| Scleroderma‐like skin changes | Carcinoid syndrome |
| Paraneoplastic pemphigus | B‐cell proliferations and thymoma or thymoma‐like neoplasms; specifically Non Hodgkin's lymphoma (42%) |
| Dermatitis herpetiformis | Lymphoma |
| Porphyria cutanea tarda and variegate porphyrias | Hepatocellular Carcinoma |
| Erythroderma and exfoliative dermatitis | Mycosis fungoides or Sézary syndrome |
| Pyoderma gangrenosum | Hematological malignancy |
| Sweet syndrome | Hematological malignancy |
Footnotes
- ^ a b Non-Hodgkin lymphoma is the most common cause of paraneoplastic pemphigus in adults. Castleman's disease is the most common cause of paraneoplastic pemphigus in children.
See also
- List of target antigens in pemphigus
- List of cutaneous conditions
- List of genes mutated in cutaneous conditions
- List of cutaneous conditions caused by mutations in keratins
References
- ^ a b Wick, Mark R.; Patterson, James W. (July 2019). "Cutaneous paraneoplastic syndromes". Seminars in Diagnostic Pathology. 36 (4): 211–228. doi: 10.1053/j.semdp.2019.01.001. ISSN 0740-2570. PMID 30736994.
- ^ Fonia, Athina; Baran, Robert (2021). "Cutaneous paraneoplastic syndromes with nail involvement". In Lipner, Shari (ed.). Nail Disorders: Diagnosis and Management, An Issue of Dermatologic Clinics. Elsevier. pp. 175–182. ISBN 978-0-323-70924-8.
Bibliography
- Bolognia, Jean L.; et al. (2007). Dermatology. St. Louis: Mosby. ISBN 1-4160-2999-0.
- James, William D.; et al. (2006). Andrews' Diseases of the Skin: Clinical Dermatology. Saunders Elsevier. ISBN 0-7216-2921-0.