From Wikipedia, the free encyclopedia
List of adverse effects of
valproic acid by frequency:
[1]
[2]
[3]
[4]
Very common (>10%)
- Nausea
- Vomiting
-
Diarrhea
- Headache
- Low platelet count (dose-related)
- Tremor (dose-related)
- Hair loss (usually temporary)
- Drowsiness
- Dizziness
-
Hyperandrogenism in females
- Seeing double
- Indigestion
-
Lazy eye
- Infection
-
Tinnitus
- Elevated aminotransferase concentrations (dose-related; indicative of liver injury)
Common (1-10%)
- High blood levels of
ammonia without symptoms
Uncommon (0.1-1%)
Rare (<0.1% frequency)
- Liver failure
-
Pancreatitis (these two usually occur in first 6 months and can be fatal)
-
Leukopenia (low white blood cell count)
-
Neutropenia (low
neutrophil count)
-
Pure red cell aplasia
-
Agranulocytosis
- Extrapyramidal syndrome (including parkinsonism, may be reversible)
- Brain problems due to high ammonia levels
- Low body temperature
- Hypersensitivity reactions including multi-organ hypersensitivity syndrome
- Eosinophilic pleural effusion
- Bone fractures (reduced BMD with long-term use)
References