The following railroad lines were owned or operated by the Pennsylvania Railroad west of Pittsburgh and Erie.
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Pittsburgh to Chicago
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Main Line (Pittsburgh to Chicago)
- Economy Branch (Baden)
- Block House Run Branch (New Brighton)
- North Rochester Branch (Rochester)
- Marginal Branch (Beaver Falls)
- Oil Street Branch (Beaver Falls)
- South Canton Branch (Canton)
- Buck Hill Branch (Canton)
- South Massillon Branch (Massillon)
- Massillon and Cleveland Branch (Massillon Junction to Clinton)
- Walhonding Branch (Loudonville to Coshocton)
- Rocky Fork Branch (Mansfield)
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Toledo Branch (Toledo Junction to Detroit)
- Water Street Branch (Toledo)
- River Branch (Toledo)
- Oakman Branch (Dearborn)
- West Belt Branch (Dearborn to Highland Park)
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Grand Rapids Branch (Fort Wayne to Mackinaw City)
- Muskegon Branch (Grand Rapids to Muskegon)
- Missaukee Branch (Missakuee Junction to Michelson)
- Traverse City Branch (Walton Junction to Traverse City)
- Harbor Springs Branch (Kegomic to Harbor Springs)
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State Line and Indiana City Railway (Clarke Junction to State Line)
- Wolf Lake Branch (Hammond)
- Hammond Branch (Hammond to Hegewisch)
- South Chicago and Southern Railroad (Colehour to Bernice)
- Calumet River Line (South Chicago to Hegewisch)
- Cummings Branch (South Chicago)
- Calumet Western Railway (South Chicago to Hegewisch)
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Cleveland Line (Rochester to Cleveland)
- Beaver Valley Railroad Branch (Vanport)
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River Branch (Yellow Creek to Bellaire)
- Wheeling Terminal Branch (Martins Ferry to Benwood)
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POV&C Railroad Branch (Bellaire to Krebs Run)
- Wegee Branch (Wegee to Webb)
- Salineville Railroad (Salineville)
- Canton-Bayard Branch (Bayard to Fairhope)
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Tuscarawas Branch (Bayard to Goshen)
- Brush Run Branch (Magnolia)
- Marietta Branch (Dover to Marietta)
- Strasburg Branch (Dover to Parral)
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Akron Branch (Hudson to Columbus)
- Dresden Branch (Killbuck to Trinway)
- Howard Branch (Howard to Millwood)
- Maple Heights Industrial Branch (Maple Heights to Cleveland)
- Kingsbury Branch (Cleveland)
- Silver Plate Branch (Cleveland)
- New Brighton to Ashtabula Harbor
- Kenwood Branch (New Brighton)
- Beaver Valley Branch (Homewood Junction to Wampum Junction)
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Mahoningtown Branch (New Castle Junction to New Castle)
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Erie and Pittsburgh Branch (New Castle to Erie)
- Sharpsville Branch (Sharpsville)
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New Castle Branch (New Castle to Stoneboro)
- Wilmington Branch (Wilmington Junction to New Wilmington)
- Wolf Creek Branch (Leesburg to Redmond)
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Erie and Pittsburgh Branch (New Castle to Erie)
- Bessemer Branch (Coverts to Walford)
- Canfield Branch (Haselton)
- Alliance Branch (Niles to Alliance)
- Sandusky Branch (Sandusky to Columbus)
Pittsburgh to St. Louis
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Main Line (Pittsburgh, PA to St. Louis, MO)
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Ohio Connecting Railway (Woods Run, Pittsburgh to Elliott, Pittsburgh)
[1]
- Duffs Branch (Esplen, Pittsburgh to Thornburg) [1]
- Sheridan Branch (Esplen, Pittsburgh to Elliott, Pittsburgh) [1]
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Chartiers Branch (Carnegie to Washington)
- Bridgeville and McDonald Branch (Bridgeville to Cecil)
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Westland Branch (Houston to Westland)
- Palanka Branch (Houston to Palanka)
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Burgetts Branch (Burgettstown to Valear)
- Hickory Branch (Burgettstown to Cherry Valley)
- Langeloth Branch (Valear to Studa)
- New Cumberland Branch (Weirton Junction to Kobuta)
- Wheeling Branch (Weirton Junction to Benwood)
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Cadiz Branch (Cadiz Junction to Cadiz)
- Georgetown Branch (Lando to Georgetown)
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Zanesville Branch (Trinway to Morrow)
- Mill Run Branch (Zanesville)
- Springfield Branch (Xenia to Springfield)
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C&X Branch (Xenia, OH to Cincinnati, OH)
- Middletown Branch (Middletown Junction, OH to Middletown, OH)
- Undercliff Branch (Rendcomb Junction, OH to Cincinnati, OH)
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Richmond Branch (Oakley, OH to Anoka, IN)
- Fort Wayne Branch (Richmond, IN to Adams Township of Allen County, IN)
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Lebanon Branch (Cincinnati, OH to Dayton, OH)
- Montgomery Branch (Blue Ash, OH to Montgomery, OH)
- Hempstead Branch (Hempstead to Clement)
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Louisville Branch (Indianapolis, IN to Louisville, KY)
- Madison Branch (Columbus, IN to Madison, IN)
- Shelbyville Branch (Columbus, IN to Dublin Junction, IN)
- New Albany Branch (Jeffersonville, IN to New Albany, IN)
- Arbegust Street Branch (Louisville, KY)
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Vincennes Branch (Indianapolis, IN to Vincennes, IN)
- Starch Works Branch (Indianapolis, IN)
- Greene County Coal Branch (Bushrod, IN to Linton, IN)
- Columbia Branch (Bicknell, IN)
- Knox County Coal Branch (Bicknell, IN)
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Vandalia Railroad (Indianapolis, IN to St. Louis, MO)
- St. Louis, Vandalia and Terre Haute Railroad (St. Louis, MO to Terre Haute, IN)
- Terre Haute and Indianapolis Rail Road (Indianapolis, IN to Terre Haute, IN)
- Terre Haute and Logansport Branch (Terre Haute, IN to Logansport, IN)
- Logansport and Toledo Branch (Logansport, IN to Toledo, OH)
- I&F Branch
- Centerpoint Branch (Stearleys to Centerpoint)
- Hadleytown Branch (Brazil to Hadleytown)
- Saline City Branch (Brazil)
- Willow Creek Branch (Staunton to Seelyville)
- Furnace Branch (Brazil)
- Glen Ayr Branch (Seelyville)
- Crawfordsville Branch (Terre Haute to Frankfort)
- Macksville North Branch (West Terre Haute)
- Macksville South Branch (West Terre Haute)
- Peoria Branch (Farrington to Peoria)
- Highland Mill Branch (Highland)
- Troy Branch (Collinsville to Troy)
- Stock Yards Branch (East St. Louis, IL)
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Ohio Connecting Railway (Woods Run, Pittsburgh to Elliott, Pittsburgh)
[1]
Columbus to Chicago
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Main Line (Columbus, OH to Chicago, IL)
- Main Line (Columbus to Indianapolis via Bradford) (Bradford, OH to New Paris, OH)
- Muncie Branch (Converse, IN to Muncie, IN)
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South Bend Branch (Logansport, IN to South Bend, IN)
- Butler Branch (Logansport, IN to Butler, IN)
- Effner Branch (Kenneth, IN to Effner, IL)
- Englewood Connecting Railway Branch (Chicago, IL)