The following is a list of prominent Afro-Guyanese, or people of Afro-Guyanese descent.
Notable people of Afro-Guyanese descent
- Deborah Cox, Canadian R&B singer-songwriter with longest-running #1 R&B track on charts
- Jason David, Canadian-born American football cornerback
- JDiggz, Canadian rapper, Afro-Guyanese mother
- Melanie Fiona, Canadian R&B singer-songwriter, who is also of Indo-Guyanese descent
- Nubya Garcia, English saxophonist and jazz musician, Guyanese mother
- David Lammy, British-born politician and lawyer
- Tessa McWatt, Guyanese-born Canadian writer
- Des'ree, English singer, Afro-Guyanese mother
- Sonnet L'Abbé, Canadian writer
- Yolanda T. Marshall, Guyanese-born Canadian writer
- Dawnn Lewis, American actress
- Leona Lewis, singer and the first winner of "The X Factor" (series 3), Guyanese father
- Jermain Jackman, singer and "The Voice UK" (2015) winner
- Derek Luke, American actor
- Maestro, Canadian rapper and actor
- Nicole Narain, Playboy model, has an Afro-Guyanese mother and her father, who is of mixed Indo-Guyanese and Chinese-Guyanese descent
- Trevor Phillips, British politician
- Joy Reid, American news correspondent for MSNBC, Afro-Guyanese mother
- Rihanna, Barbados-born singer/billionaire, Afro-Guyanese mother
- Saukrates, Canadian rapper/singer
- Eon Sinclair, bassist of Canadian rock/ska/reggae band Bedouin Soundclash
- Sean Patrick Thomas, actor ( Save the Last Dance and Barbershop)
- Phil Lynott, English-born frontman of the Irish rock band Thin Lizzy, Afro-Guyanese father
- Wretch 32, British rapper, Guyanese mother
- Vanessa Lee Chester, former American child actress (" A Little Princess", " Harriet the Spy", and " The Lost World: Jurassic Park")
- Letitia Wright, actress, who is best-known for playing Shuri in the 2018 film version of " Black Panther" and the 2022 sequel " Black Panther: Wakanda Forever"
- Roy Woods, Canadian R&B artist
- Saint JHN, Guyanese-American rapper
- Shaunette Renée Wilson, Guyanese-born American actress (" The Resident", " Billions", and "Black Panther")
Arts
- Eddy Grant, musician
- Ram John Holder, actor and musician
- Colle´ Kharis, Reggae recording artist
- Preme, Canadian rapper
- Red Café, Guyanese-American rapper
Sports
- Clifford Anderson, former British Empire featherweight contender
- Basil Butcher, former Guyanese and West Indian cricketer
- Colin Croft, former Guyanese and West Indian cricketer
- Chelsea Edghill, Guyanese table tennis player
- Roy Fredericks, former Guyanese and West Indian cricketer
- Lance Gibbs, former Guyanese and West Indian cricketer
- Vivian Harris, former WBA super lightweight champion
- Roger Harper, former Guyanese and West Indian cricketer
- Carl Hooper, former West Indian cricket captain
- Ezekiel Jackson, professional wrestler
- Clayton Lambert, American, Guyanese and West Indian cricketer, scored the most runs for Guyana
- Andrew Lewis, former WBA welterweight champion
- Clive Lloyd, former Guyanese and West Indian cricketer
- Aliann Pompey, Guyanese 400 meter sprinter
- Alana Shipp - Barbadian IFBB professional bodybuilder
- Mark McKoy, Guyanese-born Canadian sprinter
- Michael Anthony, Guyanese Boxer
Politicians and social leaders
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- Forbes Burnham, President of Guyana, 1980-1985
- Hubert Nathaniel Critchlow, father of the trade union movement in British Guiana
- Cuffy, leader of the Berbice slave uprising
- Karen de Souza (born 1958), women and children's activist
- Jack Gladstone, leader of the Demerara rebellion of 1823
- David A. Granger, President of Guyana
- Hamilton Green, 1st Muslim Prime Minister of Guyana, and in the Western world, 1985-1992
- Desmond Hoyte, President of Guyana, 1985-1992
- Sam Hinds, former President of Guyana, Prime Minister of Guyana
- Eusi Kwayana, former Guyanese cabinet member and veteran politician
- Lincoln Lewis, trade union leader
- Quamina, leader of the Demerara rebellion of 1823
- Ptolemy Reid, former Prime Minister of Guyana
Academics
- John Agard, playwright, poet and children's writer
- George Granville Monah James, historian and author
- Egbert Martin, 19th-century Guyanese poet of mixed African and European ancestry
- Walter Rodney, historian and political activist
- Ivan Gladstone Van Sertima, associate professor of Africana Studies at Rutgers University