| Lelis syndrome | |
|---|---|
| Other names | Ectodermal dysplasia-acanthosis nigricans syndrome |
 | |
| This condition is inherited in an autosomal recessive manner. | |
Lelis syndrome is a genetic disorder, a rare condition with dermatological and dental findings [1] characterized by the association of ectodermal dysplasia ( hypotrichosis and hypohidrosis) with acanthosis nigricans. Other clinical features may include palmoplantar hyperkeratosis, nail dystrophy, intellectual deficit, [2] disturbances of skin pigmentation (perioral and periorbital hyperpigmentation, vitiligo, and perinevic leukoderma) [2] and hypodontia. Transmission is autosomal recessive. [1] [3]
See also
References
- ^ a b Samdani AJ (October 2004). "Ectodermal dysplasia with acanthosis nigricans (Lelis' syndrome)". J Coll Physicians Surg Pak. 14 (10): 626–7. PMID 15456556.
- ^ a b Lelis J (June 1992). "Autosomal recessive ectodermal dysplasia". Cutis. 49 (6): 435–7. PMID 1628512.
- ^ Steiner CE, Cintra ML, Marques-de-Faria AP (December 2002). "Ectodermal dysplasia with acanthosis nigricans (Lelis syndrome)". Am. J. Med. Genet. 113 (4): 381–4. doi: 10.1002/ajmg.b.10787. PMID 12457412.
External links