Laura J. Niedernhofer (born October 6, 1964) is an American professor of biochemistry, molecular biology, and biophysics, with expertise in the fields of DNA damage, repair, progeroid syndromes and cellular senescence ^[1]

Education and career

Niedernhofer studied from 1981 to 1985 at Duke University graduating with a B.S. chemistry, from 1989 to 1990 at Georgetown University School of Medicine graduating with an M.S. in physiology, and from 1990 to 1992 at the University of Alabama at Birmingham with training in medicine. At Nashville's Vanderbilt University School of Medicine she studied from 1992 to 1996 graduating with a Ph.D. in biochemistry and from 1996 to 1998 graduating with an M.D. ^{[2] [3]} As a postdoc from 1999 to 2003, she studied mouse genetics under the supervision of Jan Hoeijmakers at Rotterdam's Erasmus University Medical Center. ^[1] Niederhofer was from 2003 to 2012 an associate professor of microbiology and molecular genetics at the University of Pittsburgh and from 2012 to 2018 an associate professor of molecular medicine at the Florida campus of Scripps Research. At the University of Minnesota from 2018 to the present, she is a full professor of biochemistry, molecular biology, and biophysics ^[4] and director of the Institute of the Biology of Aging and Metabolism, ^[2] as well head of the Niedernhofer Lab. ^[4]

In 2017 Niedernhofer was one of fifteen recipients of the Glenn Award for Research in Biological Mechanisms of Aging. ^[5] In 2018 she received the Vincent Cristofalo Rising Star Award in Aging Research from the American Federation for Aging Research. ^[1]

Selected publications

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• Niedernhofer, Laura J.; Daniels, J.Scott; Rouzer, Carol A.; Greene, Rachel E.; Marnett, Lawrence J. (2003). "Malondialdehyde, a Product of Lipid Peroxidation, is Mutagenic in Human Cells". Journal of Biological Chemistry. 278 (33): 31426–31433. doi: 10.1074/jbc.M212549200. PMID  12775726.
• Zhu, Xu-Dong; Niedernhofer, Laura; Kuster, Bernhard; Mann, Matthias; Hoeijmakers, Jan H.J; De Lange, Titia (2003). "ERCC1/XPF Removes the 3′ Overhang from Uncapped Telomeres and Represses Formation of Telomeric DNA-Containing Double Minute Chromosomes". Molecular Cell. 12 (6): 1489–1498. doi: 10.1016/S1097-2765(03)00478-7. PMID  14690602.
• Niedernhofer, Laura J.; Odijk, Hanny; Budzowska, Magda; Van Drunen, Ellen; Maas, Alex; Theil, Arjan F.; De Wit, Jan; Jaspers, N. G. J.; Beverloo, H. Berna; Hoeijmakers, Jan H. J.; Kanaar, Roland (2004). "The Structure-Specific Endonuclease Ercc1-XPF is Required to Resolve DNA Interstrand Cross-Link-Induced Double-Strand Breaks". Molecular and Cellular Biology. 24 (13): 5776–5787. doi: 10.1128/MCB.24.13.5776-5787.2004. PMC  480908. PMID  15199134.
• Niedernhofer, Laura J.; Lalai, Astrid S.; Hoeijmakers, Jan H.J. (2005). "Fanconi Anemia (Cross)linked to DNA Repair". Cell. 123 (7): 1191–1198. doi: 10.1016/j.cell.2005.12.009. PMID  16377561. S2CID  15594679.
• Niedernhofer, Laura J.; Garinis, George A.; Raams, Anja; Lalai, Astrid S.; Robinson, Andria Rasile; Appeldoorn, Esther; Odijk, Hanny; Oostendorp, Roos; Ahmad, Anwaar; Van Leeuwen, Wibeke; Theil, Arjan F.; Vermeulen, Wim; Van Der Horst, Gijsbertus T. J.; Meinecke, Peter; Kleijer, Wim J.; Vijg, Jan; Jaspers, Nicolaas G. J.; Hoeijmakers, Jan H. J. (2006). "A new progeroid syndrome reveals that genotoxic stress suppresses the somatotroph axis". Nature. 444 (7122): 1038–1043. Bibcode: 2006Natur.444.1038N. doi: 10.1038/nature05456. PMID  17183314. S2CID  4358515.
• Van Der Pluijm, Ingrid; Garinis, George A.; Brandt, Renata M. C.; Gorgels, Theo G. M. F.; Wijnhoven, Susan W.; Diderich, Karin E. M.; De Wit, Jan; Mitchell, James R.; Van Oostrom, Conny; Beems, Rudolf; Niedernhofer, Laura J.; Velasco, Susana; Friedberg, Errol C.; Tanaka, Kiyoji; Van Steeg, Harry; Hoeijmakers, Jan H. J.; Van Der Horst, Gijsbertus T. J. (2006). "Impaired Genome Maintenance Suppresses the Growth Hormone–Insulin-Like Growth Factor 1 Axis in Mice with Cockayne Syndrome". PLOS Biology. 5 (1): e2. doi: 10.1371/journal.pbio.0050002. PMC  1698505. PMID  17326724.
• Jaspers, Nicolaas G.J.; Raams, Anja; Silengo, Margherita Cirillo; Wijgers, Nils; Niedernhofer, Laura J.; Robinson, Andria Rasile; Giglia-Mari, Giuseppina; Hoogstraten, Deborah; Kleijer, Wim J.; Hoeijmakers, Jan H.J.; Vermeulen, Wim (2007). "First Reported Patient with Human ERCC1 Deficiency Has Cerebro-Oculo-Facio-Skeletal Syndrome with a Mild Defect in Nucleotide Excision Repair and Severe Developmental Failure". The American Journal of Human Genetics. 80 (3): 457–466. doi: 10.1086/512486. PMC  1821117. PMID  17273966.
• Ahmad, Anwaar; Robinson, Andria Rasile; Duensing, Anette; Van Drunen, Ellen; Beverloo, H. Berna; Weisberg, David B.; Hasty, Paul; Hoeijmakers, Jan H. J.; Niedernhofer, Laura J. (2008). "ERCC1-XPF Endonuclease Facilitates DNA Double-Strand Break Repair". Molecular and Cellular Biology. 28 (16): 5082–5092. doi: 10.1128/MCB.00293-08. PMC  2519706. PMID  18541667.
• Schumacher, Björn; Van Der Pluijm, Ingrid; Moorhouse, Michael J.; Kosteas, Theodore; Robinson, Andria Rasile; Suh, Yousin; Breit, Timo M.; Van Steeg, Harry; Niedernhofer, Laura J.; Van Ijcken, Wilfred; Bartke, Andrzej; Spindler, Stephen R.; Hoeijmakers, Jan H. J.; Van Der Horst, Gijsbertus T. J.; Garinis, George A. (2008). "Delayed and Accelerated Aging Share Common Longevity Assurance Mechanisms". PLOS Genetics. 4 (8): e1000161. doi: 10.1371/journal.pgen.1000161. PMC  2493043. PMID  18704162.
• Tilstra, J. S.; Clauson, C. L.; Niedernhofer, L. J.; Robbins, P. D. (2011). "NF-κB in Aging and Disease". Aging and Disease. 2 (6): 449–465. PMC  3295063. PMID  22396894.
• Tilstra, Jeremy S.; Robinson, Andria R.; Wang, Jin; Gregg, Siobhán Q.; Clauson, Cheryl L.; Reay, Daniel P.; Nasto, Luigi A.; St Croix, Claudette M.; Usas, Arvydas; Vo, Nam; Huard, Johnny; Clemens, Paula R.; Stolz, Donna B.; Guttridge, Denis C.; Watkins, Simon C.; Garinis, George A.; Wang, Yinsheng; Niedernhofer, Laura J.; Robbins, Paul D. (2012). "NF-κB inhibition delays DNA damage–induced senescence and aging in mice". Journal of Clinical Investigation. 122 (7): 2601–2612. doi: 10.1172/JCI45785. PMC  3386805. PMID  22706308.
• Clauson, C.; Scharer, O. D.; Niedernhofer, L. (2013). "Advances in Understanding the Complex Mechanisms of DNA Interstrand Cross-Link Repair". Cold Spring Harbor Perspectives in Biology. 5 (10): a012732. doi: 10.1101/cshperspect.a012732. PMC  4123742. PMID  24086043.
• Fu, Lijuan; Guerrero, Candace R.; Zhong, Na; Amato, Nicholas J.; Liu, Yunhua; Liu, Shuo; Cai, Qian; Ji, Debin; Jin, Seung-Gi; Niedernhofer, Laura J.; Pfeifer, Gerd P.; Xu, Guo-Liang; Wang, Yinsheng (2014). "Tet-Mediated Formation of 5-Hydroxymethylcytosine in RNA". Journal of the American Chemical Society. 136 (33): 11582–11585. doi: 10.1021/ja505305z. PMC  4140497. PMID  25073028.
• Zhu, Yi; et al. (2015). "The Achilles' heel of senescent cells: From transcriptome to senolytic drugs". Aging Cell. 14 (4): 644–658. doi: 10.1111/acel.12344. PMC  4531078. PMID  25754370.
• Zhu, Yi; Tchkonia, Tamara; Fuhrmann-Stroissnigg, Heike; Dai, Haiming M.; Ling, Yuanyuan Y.; Stout, Michael B.; Pirtskhalava, Tamar; Giorgadze, Nino; Johnson, Kurt O.; Giles, Cory B.; Wren, Jonathan D.; Niedernhofer, Laura J.; Robbins, Paul D.; Kirkland, James L. (2016). "Identification of a novel senolytic agent, navitoclax, targeting the BCL-2 family of anti-apoptotic factors". Aging Cell. 15 (3): 428–435. doi: 10.1111/acel.12445. PMC  4854923. PMID  26711051.
• Fuhrmann-Stroissnigg, Heike; Ling, Yuan Yuan; Zhao, Jing; McGowan, Sara J.; Zhu, Yi; Brooks, Robert W.; Grassi, Diego; Gregg, Siobhan Q.; Stripay, Jennifer L.; Dorronsoro, Akaitz; Corbo, Lana; Tang, Priscilla; Bukata, Christina; Ring, Nadja; Giacca, Mauro; Li, Xuesen; Tchkonia, Tamara; Kirkland, James L.; Niedernhofer, Laura J.; Robbins, Paul D. (2017). "Identification of HSP90 inhibitors as a novel class of senolytics". Nature Communications. 8 (1): 422. Bibcode: 2017NatCo...8..422F. doi: 10.1038/s41467-017-00314-z. PMC  5583353. PMID  28871086. S2CID  499103.
• Kirkland, James L.; Tchkonia, Tamara; Zhu, Yi; Niedernhofer, Laura J.; Robbins, Paul D. (2017). "The Clinical Potential of Senolytic Drugs". Journal of the American Geriatrics Society. 65 (10): 2297–2301. doi: 10.1111/jgs.14969. PMC  5641223. PMID  28869295.
• Zhu, Y.; Doornebal, E. J.; Pirtskhalava, T.; Giorgadze, N.; Wentworth, M.; Fuhrmann-Stroissnigg, H.; Niedernhofer, L. J.; Robbins, P. D.; Tchkonia, T.; Kirkland, J. L. (2017). "New agents that target senescent cells: The flavone, fisetin, and the BCL-X_L inhibitors, A1331852 and A1155463". Aging. 9 (3): 955–963. doi: 10.18632/aging.101202. PMC  5391241. PMID  28273655.
• Xu, Ming; et al. (2018). "Senolytics improve physical function and increase lifespan in old age". Nature Medicine. 24 (8): 1246–1256. doi: 10.1038/s41591-018-0092-9. PMC  6082705. PMID  29988130.
• Yousefzadeh, Matthew J.; Zhu, Yi; McGowan, Sara J.; Angelini, Luise; Fuhrmann-Stroissnigg, Heike; Xu, Ming; Ling, Yuan Yuan; Melos, Kendra I.; Pirtskhalava, Tamar; Inman, Christina L.; McGuckian, Collin; Wade, Erin A.; Kato, Jonathon I.; Grassi, Diego; Wentworth, Mark; Burd, Christin E.; Arriaga, Edgar A.; Ladiges, Warren L.; Tchkonia, Tamara; Kirkland, James L.; Robbins, Paul D.; Niedernhofer, Laura J. (2018). "Fisetin is a senotherapeutic that extends health and lifespan". eBioMedicine. 36: 18–28. doi: 10.1016/j.ebiom.2018.09.015. PMC  6197652. PMID  30279143.
• Gorgoulis, Vassilis; Adams, Peter D.; Alimonti, Andrea; Bennett, Dorothy C.; Bischof, Oliver; Bishop, Cleo; Campisi, Judith; Collado, Manuel; Evangelou, Konstantinos; Ferbeyre, Gerardo; Gil, Jesús; Hara, Eiji; Krizhanovsky, Valery; Jurk, Diana; Maier, Andrea B.; Narita, Masashi; Niedernhofer, Laura; Passos, João F.; Robbins, Paul D.; Schmitt, Clemens A.; Sedivy, John; Vougas, Konstantinos; von Zglinicki, Thomas; Zhou, Daohong; Serrano, Manuel; Demaria, Marco (2019). "Cellular Senescence: Defining a Path Forward". Cell. 179 (4): 813–827. doi: 10.1016/j.cell.2019.10.005. hdl: 10044/1/74383. PMID  31675495. S2CID  204971698.
• Robbins, Paul D.; Jurk, Diana; Khosla, Sundeep; Kirkland, James L.; Lebrasseur, Nathan K.; Miller, Jordan D.; Passos, João F.; Pignolo, Robert J.; Tchkonia, Tamar; Niedernhofer, Laura J. (2021). "Senolytic Drugs: Reducing Senescent Cell Viability to Extend Health Span". Annual Review of Pharmacology and Toxicology. 61: 779–803. doi: 10.1146/annurev-pharmtox-050120-105018. PMC  7790861. PMID  32997601.

References

External links

• "AGE Presents Laura Niedernhofer - Genome Instability and Aging". YouTube. American Aging Association. May 24, 2021.
• "Healthy Aging at Tufts: Speaker Dr. Laura Niedernhofer". YouTube. Healthy Aging at Tufts University. February 5, 2021.
• "Laura Niedernhofer presents at ARDD 2021". YouTube. ARDD2021. October 26, 2021.