From Wikipedia, the free encyclopedia
Protein-coding gene in the species Homo sapiens
U6 snRNA-associated Sm-like protein LSm4 is a
protein that in humans is encoded by the LSM4
gene .
[5]
[6]
[7]
Sm-like proteins were identified in a variety of organisms based on
sequence homology with the Sm protein family (see SNRPD2; MIM 601061). Sm-like proteins contain the Sm sequence motif, which consists of 2 regions separated by a linker of variable length that folds as a loop. The Sm-like proteins are thought to form a stable
heteromer present in
tri-snRNP particles, which are important for
pre-mRNA splicing.[supplied by OMIM]
[7]
References
^
a
b
c
GRCh38: Ensembl release 89: ENSG00000130520 –
Ensembl , May 2017
^
a
b
c
GRCm38: Ensembl release 89: ENSMUSG00000031848 –
Ensembl , May 2017
^
"Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^
"Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^ Salgado-Garrido J, Bragado-Nilsson E, Kandels-Lewis S, Seraphin B (Aug 1999).
"Sm and Sm-like proteins assemble in two related complexes of deep evolutionary origin" . EMBO J . 18 (12): 3451–62.
doi :
10.1093/emboj/18.12.3451 .
PMC
1171424 .
PMID
10369684 .
^ Achsel T, Brahms H, Kastner B, Bachi A, Wilm M, Luhrmann R (Dec 1999).
"A doughnut-shaped heteromer of human Sm-like proteins binds to the 3'-end of U6 snRNA, thereby facilitating U4/U6 duplex formation in vitro" . EMBO J . 18 (20): 5789–802.
doi :
10.1093/emboj/18.20.5789 .
PMC
1171645 .
PMID
10523320 .
^
a
b
"Entrez Gene: LSM4 LSM4 homolog, U6 small nuclear RNA associated (S. cerevisiae)" .
Further reading
Singer J, Roberts-Ems J, Luthardt FW, Riggs AD (1980).
"Methylation of DNA in mouse early embryos, teratocarcinoma cells and adult tissues of mouse and rabbit" . Nucleic Acids Res . 7 (8): 2369–85.
doi :
10.1093/nar/7.8.2369 .
PMC
342390 .
PMID
523320 .
Friesen WJ, Dreyfuss G (2000).
"Specific sequences of the Sm and Sm-like (Lsm) proteins mediate their interaction with the spinal muscular atrophy disease gene product (SMN)" . J. Biol. Chem . 275 (34): 26370–5.
doi :
10.1074/jbc.M003299200 .
PMID
10851237 .
Hu RM, Han ZG, Song HD, et al. (2000).
"Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning" . Proc. Natl. Acad. Sci. U.S.A . 97 (17): 9543–8.
Bibcode :
2000PNAS...97.9543H .
doi :
10.1073/pnas.160270997 .
PMC
16901 .
PMID
10931946 .
Eystathioy T, Peebles CL, Hamel JC, et al. (2002).
"Autoantibody to hLSm4 and the heptameric LSm complex in anti-Sm sera" . Arthritis Rheum . 46 (3): 726–34.
doi :
10.1002/art.10220 .
PMID
11920408 .
Strausberg RL, Feingold EA, Grouse LH, et al. (2003).
"Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–903.
Bibcode :
2002PNAS...9916899M .
doi :
10.1073/pnas.242603899 .
PMC
139241 .
PMID
12477932 .
Ingelfinger D, Arndt-Jovin DJ, Lührmann R, Achsel T (2003).
"The human LSm1-7 proteins colocalize with the mRNA-degrading enzymes Dcp1/2 and Xrnl in distinct cytoplasmic foci" . RNA . 8 (12): 1489–501.
doi :
10.1017/S1355838202021726 .
PMC
1370355 .
PMID
12515382 .
Lehner B, Sanderson CM (2004).
"A Protein Interaction Framework for Human mRNA Degradation" . Genome Res . 14 (7): 1315–23.
doi :
10.1101/gr.2122004 .
PMC
442147 .
PMID
15231747 .
Gerhard DS, Wagner L, Feingold EA, et al. (2004).
"The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)" . Genome Res . 14 (10B): 2121–7.
doi :
10.1101/gr.2596504 .
PMC
528928 .
PMID
15489334 .
Fürst J, Schedlbauer A, Gandini R, et al. (2005).
"ICln159 folds into a pleckstrin homology domain-like structure. Interaction with kinases and the splicing factor LSm4" . J. Biol. Chem . 280 (35): 31276–82.
doi :
10.1074/jbc.M500541200 .
PMID
15905169 .
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature . 437 (7062): 1173–8.
Bibcode :
2005Natur.437.1173R .
doi :
10.1038/nature04209 .
PMID
16189514 .
S2CID
4427026 .
Yang ZQ, Streicher KL, Ray ME, et al. (2007).
"Multiple interacting oncogenes on the 8p11-p12 amplicon in human breast cancer" . Cancer Res . 66 (24): 11632–43.
doi :
10.1158/0008-5472.CAN-06-2946 .
PMID
17178857 .
Ewing RM, Chu P, Elisma F, et al. (2007).
"Large-scale mapping of human protein–protein interactions by mass spectrometry" . Mol. Syst. Biol . 3 (1): 89.
doi :
10.1038/msb4100134 .
PMC
1847948 .
PMID
17353931 .