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Pharmaceutical science professor
Kristy M. Ainslie is a Fred Eshelman Distinguished Professor in pharmaceutical science at
University of North Carolina at Chapel Hill in the
Eshelman School of Pharmacy and chair of the Division of
Pharmacoengineering and Molecular
Pharmaceutics . She is also joint in the
UNC School of Medicine Department of
Microbiology and
Immunology and affiliated faculty in the
UNC /
NC State joint
Biomedical Engineering department. Additionally, she is part of
UNC's Biological and Biomedical Sciences Program (BBSP).
Background
Ainslie completed her Bachelor of Science in
chemical engineering from
Michigan State University in 1999. After working as an environmental engineer at
Malcolm Pirnie , she began graduate school at
Penn State as a fellow in the Huck Institutes of the Life Science. In 2003, she completed her Master of Science in
chemical engineering under
John Tarbell , focusing on
shear stress modulation of
vascular smooth muscle cell contraction.
[1]
[2]
[3]
[4]
[5] Two years later in 2005, she completed her PhD in
Chemical engineering under Micheal Pishko, focusing on protein adhesion and cell responses to
nanomaterials .
[6]
[7]
[8]
[9]
[10] After a brief post doc at the
microcantilever start-up Protiveris, she worked with Lloyd Whitman at the
United States Naval Research Laboratory .
[11] In 2006, she began a post doc at
University of San Francisco in the department of bioengineering and therapeutic sciences under the direction of
Tejal Desai . The focus of Ainslie's research at UCSF was on
microfabricated
oral
drug delivery
[12]
[13] carriers and immune responses to planar
nanomaterials .
[14]
[15]
Ainslie began her career as a
tenure-track
assistant professor at
Ohio State University in the school of
pharmacy in the division of
pharmaceutics and pharmaceutical chemistry. In 2014, Ainslie moved to the
University of North Carolina at Chapel Hill and the
UNC Eshelman School of Pharmacy division of
pharmacoengineering and molecular
pharmaceutics as an
associate professor .
Career
Ainslie has several areas of focus for her lab:
References
^ Sharma, Ritu; Yellowley, Claire; Civelek, Mete; Ainslie, Kristy; Hodgson, Louis; Tarbell, John; Donahue, Hennry (2002).
"Intracellular Calcium Changes in Rat Aortic Smooth Muscle Cells in Response to Fluid Flow" . Annals of Biomedical Engineering . 30 (3): 371–8.
doi :
10.1114/1.1470179 .
PMC
4472337 .
PMID
12051621 .
^ Civelek, Mete; Ainslie, Kristy; Garanich, Jeffery; Tarbell, John (2002). "Smooth muscle cells contract in response to fluid flow via a Ca2+-independent signaling mechanism". J Appl Physiol . 93 (6): 1907–17.
CiteSeerX
10.1.1.490.2931 .
doi :
10.1152/japplphysiol.00988.2001 .
PMID
12391063 .
S2CID
6734621 .
^ Florian, Jeffery; Kosky, Jason; Ainslie, Kristy; Pang, Zhang; Dull, Randall; Tarbell, John (2003).
"Heparan sulfate proteoglycan is a mechanosensor on endothelial cells" . Circulation . 93 (10): e136–42.
doi :
10.1161/01.RES.0000101744.47866.D5 .
PMID
14563712 .
^ Ainslie, Kristy; Shi, Z; Garanich, Jeffery; Tarbell, John (2004). "Rat aortic smooth muscle cells contract in response to serum and its components in a calcium independent manner". Annals of Biomedical Engineering . 32 (12): 1667–75.
doi :
10.1007/s10439-004-7820-7 .
PMID
15675680 .
S2CID
12752100 .
^ Ainslie, Kristy; Garanich, Jeffery; Dull, Randall; Tarbell, John (2005). "Vascular smooth muscle cell glycocalyx influences shear stress-mediated contractile response". J Appl Physiol . 98 (1): 242–9.
doi :
10.1152/japplphysiol.01006.2003 .
PMID
15322072 .
S2CID
19602119 .
^ Dyer, Maureen; Ainslie, Kristy; Pishko, Micheal (2007). "Protein adhesion on silicon-supported hyperbranched poly(ethylene glycol) and poly(allylamine) thin films". Langmuir . 23 (13): 7018–23.
doi :
10.1021/la7004997 .
PMID
17506587 .
^ Ainslie, Kristy; Sharma, Gurav; Dyer, Maureen; Grimes, Craig; Pishko, Micheal (2005). "Attenuation of protein adsorption on static and oscillating magnetostrictive nanowires". Nano Letters . 5 (9): 1852–6.
Bibcode :
2005NanoL...5.1852A .
doi :
10.1021/nl051117u .
PMID
16159237 .
^ Ainslie, Kristy; Bachelder, Eric; Borka, Sachin; Zahr, Alisar; Sen, Ayusman; Badding, John; Pishko, Micheal (2007). "Cell adhesion on nanofibrous polytetrafluoroethylene (nPTFE)". Langmuir . 23 (2): 747–54.
doi :
10.1021/la060948s .
PMID
17209629 .
^ Kristy, Ainslie; Bachelder, Eric; Sharma, Gurav; Grimes, Craig; Pishko, Micheal (2009). "Macrophage cell adhesion and inflammation cytokines on magnetostrictive nanowires". Nanotoxicology . 1 (4): 279.
doi :
10.1080/17435390701781142 .
S2CID
85936269 .
^ Bachelder, Eric; Ainslie, Kristy; Pishko, Micheal (2005). "Utilizing a quartz crystal microbalance for quantifying CD4+ T cell counts". Sensor Letters . 3 (3): 211.
doi :
10.1166/sl.2005.029 .
^ Stine, Rory; Cole, Christina; Ainslie, Kristy; Mulvaney, Shawn; Whitman, Lloyd (2007). "Formation of primary amines on silicon nitride surfaces: a direct, plasma-based pathway to functionalization". Langmuir . 23 (8): 4400–4.
doi :
10.1021/la0635653 .
PMID
17323989 .
^ Ainslie, Kristy; Kraning, Casey; Desai, Tejal (2008).
"Microfabrication of an asymmetric, multi-layered microdevice for controlled release of orally delivered therapeutics" . Lab Chip . 8 (7): 1042–7.
doi :
10.1039/b800604k .
PMC
2969854 .
PMID
18584077 .
^ Ainslie, Kristy; Lowe, Rachel; Beaudette, Tristan; Petty, Lamar; Bachelder, Eric; Desai, Tejal (2009).
"Microfabricated devices for enhanced bioadhesive drug delivery: attachment to and small-molecule release through a cell monolayer under flow" . Small . 5 (24): 2857–63.
doi :
10.1002/smll.200901254 .
PMID
19787677 .
^ Kristy, Ainslie; Tao, Sarah; Popat, Ketul; Daniels, Hugh; Hardev, Veeral; Grimes, Craig; Desai, Tejal (2009).
"In vitro inflammatory response of nanostructured titania, silicon oxide, and polycaprolactone" . J Biomed Mater Res A . 91 (3): 647–55.
doi :
10.1002/jbm.a.32262 .
PMID
18988278 .
^ Ainslie, Kristy; Tao, Sarah; Popat, Ketul; Desai, Tejal (2008). "In vitro immunogenicity of silicon-based micro- and nanostructured surfaces". ACS Nano . 2 (5): 1076–84.
doi :
10.1021/nn800071k .
PMID
19206506 .
^ Kauffman, KJ; Do, C; Sharma, S; Gallovic, MD; Bachelder, EM; Ainslie, KM (Aug 2012). "Synthesis and characterization of acetalated dextran polymer and microparticles with ethanol as a degradation product". ACS Appl Mater Interfaces . 4 (8): 4149–55.
doi :
10.1021/am3008888 .
hdl :
1811/86186 .
PMID
22833690 .
^ Bachelder, EM; Beaudette, TT; Broaders, KE; Dashe, J; Fréchet, JM (Aug 2008).
"Acetal-derivatized dextran: an acid-responsive biodegradable material for therapeutic applications" . Journal of the American Chemical Society . 130 (32): 10494–5.
doi :
10.1021/ja803947s .
PMC
2673804 .
PMID
18630909 .
^ Frechet, JM; Bachelder, EM; Beaudette, TT; Broaders, KE.
"Acid-Degradable and Bioerodible Modified Polyhydroxylated Materials" . Google Patent .
Archived from the original on 2017-08-07. Retrieved 2018-06-26 .
^ Chen, Naihan; Johnson, Monica; Collier, Micheal; Gallovic, Matthew; Johnson, Monica; Ainslie, Kristy (2018).
"Tunable degradation of acetalated dextran microparticles enables controlled vaccine adjuvant and antigen delivery to modulate adaptive immune responses" . Journal of Controlled Release . 273 : 147–159.
doi :
10.1016/j.jconrel.2018.01.027 .
PMC
5835201 .
PMID
29407676 .
^ Ainslie, Kristy.
"Encapsulated Active Vitamin D Vaccine for the Treatment of Multiple Sclerosis" . Grantome .
Archived from the original on 15 October 2019. Retrieved 15 October 2019 .
^ Collier, MA; Peine, KJ; Gautum, S; Oghumu, S; Varikuti, S; Borteh, H; Papenfuss, TL; Satoskar, AR; Bachelder, EM; Ainslie, KM (Feb 29, 2016).
"Host-mediated Leishmania donovani treatment using AR-12 encapsulated in acetalated dextran microparticles" . International Journal of Pharmaceutics . 499 (1–2): 186–94.
doi :
10.1016/j.ijpharm.2016.01.004 .
PMC
5730989 .
PMID
26768723 .
^ Ainslie; et al.
"COMPOSITIONS AND METHODS FOR INHIBITING LEISHMANIA" . Free Patents Online .
Archived from the original on 2018-06-27. Retrieved 2018-06-26 .
^ Hoang, KV; Borteh, HM; Rajaram, MV; Peine, KJ; Curry, H; Collier, MA; Homsy, ML; Bachelder, EM; Gunn, JS; Schlesinger, LS; Ainslie, KM (Dec 2014).
"Acetalated dextran encapsulated AR-12 as a host-directed therapy to control Salmonella infection" . Int J Pharm . 477 (1–2): 334–43.
doi :
10.1016/j.ijpharm.2014.10.022 .
PMC
4267924 .
PMID
25447826 .
^ Hoang, KV; Curry, H; Collier, MA; Borteh, H; Bachelder, EM; Schlesinger, LS; Gunn, JS; Ainslie, KM (Mar 25, 2016).
"Needle-Free Delivery of Acetalated Dextran-Encapsulated AR-12 Protects Mice from Francisella tularensis Lethal Challenge" . Antimicrob Agents Chemother . 60 (4): 2052–62.
doi :
10.1128/AAC.02228-15 .
PMC
4808193 .
PMID
26787696 .
^ Gallovic, Matthew; Schully, Kevin; Bell, Matthew; Elberson, Margret; Palmer, John; Darko, Christen; Bachelder, Eric; Keane-Myers, Andrea; Ainslie, Kristy (2016). "Acetalated Dextran Microparticulate Vaccine Formulated via Coaxial Electrospray Preserves Toxin Neutralization and Enhances Murine Survival Following Inhalational Bacillus Anthracis Exposure". Advanced Healthcare Materials . 5 (20): 2617–2627.
doi :
10.1002/adhm.201600642 .
PMID
27594343 .
S2CID
42823279 .
^ Junkins, Robert; Gallovic, Matthew; Johnson, Brandon; Collier, Micheal; Watkins-Schulz, Rebekah; Cheng, Ning; David, Clement; McGee, Charles; Sempowski, Greg; Shterev, Ivo; McKinnon, Karen; Bachelder, Eric; Ainslie, Kristy; Ting, Jenny (2018).
"A robust microparticle platform for a STING-targeted adjuvant that enhances both humoral and cellular immunity during vaccination" . J Control Release . 270 : 1–13.
doi :
10.1016/j.jconrel.2017.11.030 .
PMC
5808851 .
PMID
29170142 .
^ Graham-Gurysh, Elizabeth; Moore, Kathryn; Satterlee, Andrew; Sheetz, Kevin; Lin; Bachelder, Eric; Miller, C. Ryan; Hingtgen, Shawn; Ainslie, Kristy (2018).
"Sustained Delivery of Doxorubicin via Acetalated Dextran Scaffold Prevents Glioblastoma Recurrence after Surgical Resection" . Mol Pharm . 15 (3): 1309–1318.
doi :
10.1021/acs.molpharmaceut.7b01114 .
PMC
5999333 .
PMID
29342360 .
External links