| Knuckle pads | |
|---|---|
| Specialty |
Rheumatology
 |
Knuckle pads (also known as " Heloderma", meaning similar to the skin of the Gila monster lizard for which it is named) are circumscribed, keratotic, fibrous growths over the dorsa of the interphalangeal joints. [1] They are described as well-defined, round, plaque-like, fibrous thickening that may develop at any age, and grow to be 10 to 15mm in diameter in the course of a few weeks or months, then go away over time. [2]
Knuckle pads are sometimes associated with Dupuytren's contracture [3] and camptodactyly, [2]: 595 and histologically, the lesions are fibromas. [2]: 595 [4] Knuckle pads are generally non-responsive to treatment, including corticosteroids, and tend to recur after surgery; however, there has been some effectiveness with intralesional fluorouracil. [5]
See also
References
- ^ Mackey, SL; Cobb, MW (1994). "Knuckle pads". Cutis. 54 (3): 159–160. PMID 7813233.
- ^ a b c James, WD; Berger, TG; Elston, DM (2005). Andrews' Diseases of the Skin: Clinical Dermatology (11th ed.). Saunders. p. 595. ISBN 0-7216-2921-0.
- ^ Mikkelsen, Otto (October 1, 1977). "Knuckle Pads in Dupuytren's Disease". Journal of Hand Surgery. 9 (3): 301–305. doi: 10.1016/S0072-968X(77)80121-6. PMID 608634. S2CID 7999131. Retrieved 27 October 2020.
- ^ Meinecke, R; Lagier, R (September 1975). "Pathology of "knuckle pads"". Virchows Archiv. 365 (3): 185–191. doi: 10.1007/BF00434037. PMID 804749. S2CID 4518671. Retrieved 27 October 2020.
- ^ Weiss, E; Amini, S (2007). "A Novel Treatment for Knuckle Pads With Intralesional Fluorouracil". Arch Dermatol. 143 (11): 1447–1462. doi: 10.1001/archderm.143.11.1458. PMID 18025384.
Further reading
- Guberman D; et al. (1996). ""Knuckle pads-a forgotten skin condition " report of a case and review of the literature". Cutis. 57 (4): 241–242. PMID 8727774.
- Ly Y; et al. (2003). "A novel mutation of keratin 9 in epidermolytic palmoplantar keratoderma combined with knuckle pads". Am J Med Genet. 120A (3): 345–9. doi: 10.1002/ajmg.a.20090. PMID 12838553. S2CID 2717431.
- Peterson CM; et al. (2000). "Knuckle pads: does knuckle cracking play an etiologic role?". Pediatr Dermatol. 17 (6): 450–2. doi: 10.1046/j.1525-1470.2000.01819.x. PMID 11123776. S2CID 22815331.
External links