KLC3 References

KLC3
Identifiers
Aliases	KLC3, KLC2, KLC2L, KLCt, KNS2B, kinesin light chain 3
External IDs	OMIM: 601334 MGI: 1277971 HomoloGene: 14899 GeneCards: KLC3
Gene location ( Human)
Chr.	Chromosome 19 (human)
End	45,351,520 bp
Gene location ( Mouse)
Chr.	Chromosome 7 (mouse)
End	19,138,029 bp
RNA expression pattern
	Top expressed in
	skin of abdomen; ; amniotic fluid; ; superficial temporal artery; ; vulva; ; external globus pallidus; ; oral cavity; ; nipple; ; vena cava; ; cardia; ; body of tongue;
	Top expressed in
	lip; ; esophagus; ; hair follicle; ; skin of back; ; skin of abdomen; ; olfactory epithelium; ; seminiferous tubule; ; retinal pigment epithelium; ; cornea; ; submandibular gland;
	More reference expression data
	n/a
Gene ontology
Molecular function	microtubule binding; microtubule motor activity; protein binding; kinesin binding;
Cellular component	cytoplasm; neuron projection; motile cilium; microtubule; cytoskeleton; kinesin complex; ciliary rootlet;
Biological process	axo-dendritic transport;
	Sources: Amigo / QuickGO
Orthologs
	147700
	232943
	ENSG00000104892
	ENSMUSG00000040714
	Q6P597
	Q91W40
	NM_145275; NM_177417
	NM_001286038; NM_001286039; NM_146182
	NP_803136
	NP_001272967; NP_001272968; NP_666294; NP_001390614
	Wikidata
View/Edit Human	View/Edit Mouse

Kinesin light chain 3 is a protein that in humans is encoded by the KLC3 gene.^[5]

Function

This gene encodes a member of the kinesin light chain gene family. Kinesins are molecular motors involved in the transport of cargo along microtubules, and are composed of two kinesin heavy chain (KHC) and two kinesin light chain (KLC) molecules. KLCs are thought to typically be involved in binding cargo and regulating kinesin activity. In the rat, a protein similar to this gene product is expressed in post-meiotic spermatids, where it associates with structural components of sperm tails and mitochondria.^[5]

Interactions

KLC3 has been shown to interact with YWHAH.^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000104892 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000040714 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b "Entrez Gene: KLC3 kinesin light chain 3".
^ Ichimura T, Wakamiya-Tsuruta A, Itagaki C, Taoka M, Hayano T, Natsume T, Isobe T (Apr 2002). "Phosphorylation-dependent interaction of kinesin light chain 2 and the 14-3-3 protein". Biochemistry. 41 (17): 5566–72. doi: 10.1021/bi015946f. PMID 11969417.

Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Molecular Systems Biology. 3 (1): 89. doi: 10.1038/msb4100134. PMC 1847948. PMID 17353931.
Zhang Y, Oko R, van der Hoorn FA (Nov 2004). "Rat kinesin light chain 3 associates with spermatid mitochondria". Developmental Biology. 275 (1): 23–33. doi: 10.1016/j.ydbio.2004.07.014. PMC 3138780. PMID 15464570.
Jin J, Smith FD, Stark C, Wells CD, Fawcett JP, Kulkarni S, Metalnikov P, O'Donnell P, Taylor P, Taylor L, Zougman A, Woodgett JR, Langeberg LK, Scott JD, Pawson T (Aug 2004). "Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization". Current Biology. 14 (16): 1436–50. Bibcode: 2004CBio...14.1436J. doi: 10.1016/j.cub.2004.07.051. PMID 15324660. S2CID 2371325.
Bhullar B, Zhang Y, Junco A, Oko R, van der Hoorn FA (May 2003). "Association of kinesin light chain with outer dense fibers in a microtubule-independent fashion". The Journal of Biological Chemistry. 278 (18): 16159–68. doi: 10.1074/jbc.M213126200. PMC 3178653. PMID 12594206.
Yang J, Liu X, Yue G, Adamian M, Bulgakov O, Li T (Nov 2002). "Rootletin, a novel coiled-coil protein, is a structural component of the ciliary rootlet". The Journal of Cell Biology. 159 (3): 431–40. doi: 10.1083/jcb.200207153. PMC 2173070. PMID 12427867.
Ichimura T, Wakamiya-Tsuruta A, Itagaki C, Taoka M, Hayano T, Natsume T, Isobe T (Apr 2002). "Phosphorylation-dependent interaction of kinesin light chain 2 and the 14-3-3 protein". Biochemistry. 41 (17): 5566–72. doi: 10.1021/bi015946f. PMID 11969417.
Junco A, Bhullar B, Tarnasky HA, van der Hoorn FA (May 2001). "Kinesin light-chain KLC3 expression in testis is restricted to spermatids". Biology of Reproduction. 64 (5): 1320–30. doi: 10.1095/biolreprod64.5.1320. PMC 3161965. PMID 11319135.
Rahman A, Kamal A, Roberts EA, Goldstein LS (Sep 1999). "Defective kinesin heavy chain behavior in mouse kinesin light chain mutants". The Journal of Cell Biology. 146 (6): 1277–88. doi: 10.1083/jcb.146.6.1277. PMC 2156125. PMID 10491391.
Rahman A, Friedman DS, Goldstein LS (Jun 1998). "Two kinesin light chain genes in mice. Identification and characterization of the encoded proteins". The Journal of Biological Chemistry. 273 (25): 15395–403. doi: 10.1074/jbc.273.25.15395. PMID 9624122.
Lamerdin JE, Stilwagen SA, Ramirez MH, Stubbs L, Carrano AV (Jun 1996). "Sequence analysis of the ERCC2 gene regions in human, mouse, and hamster reveals three linked genes". Genomics. 34 (3): 399–409. doi: 10.1006/geno.1996.0303. PMID 8786141.

This article on a gene on human chromosome 19 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000104892 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000040714 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: KLC3 kinesin light chain 3".

[pmid11969417-6] Ichimura T, Wakamiya-Tsuruta A, Itagaki C, Taoka M, Hayano T, Natsume T, Isobe T (Apr 2002). "Phosphorylation-dependent interaction of kinesin light chain 2 and the 14-3-3 protein". Biochemistry. 41 (17): 5566–72. doi: 10.1021/bi015946f. PMID 11969417.

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Function

Interactions

References

Further reading