Biologist and microscopist
Julia Mahamid
Alma mater Known for
cryo-electron tomography Scientific career Fields Institutions
Thesis Structural Investigation of Bone Mineralization Processes in the Zebrafish Fin and Embryonic Mouse Models
[1] (2010) Academic advisors
Website
Mahamid Group
Julia Mahamid is a cell biologist, structural biologist, and electron microscopist at the
European Molecular Biology Laboratory in
Heidelberg, Germany , who utilizes biomolecular condensates and advanced cellular
cryo-electron tomography to enhance the comprehension of the functional organization of the
cytoplasm . She leads the Mahamid Group.
[2]
Education
Mahamid completed her
Biology studies at the
Technion – Israel Institute of Technology ,
Israel between 2000 and 2003. After that, she pursued her Master's degree in
Chemistry from 2003 to 2005, at the
Weizmann Institute of Science , Israel, under the guidance of
Lia Addadi in collaboration with Dan Caspi. Later, from 2006 to 2010, Mahamid completed her Ph.D. studies under the supervision of Lia Addadi and Steve Weiner.
[1]
Career and research
For her postgraduate work, from 2011 to 2017, Mahamid worked as a
postdoctoral researcher the guidance of
Wolfgang Baumeister at the
Max Planck Institute of Biochemistry in
Martinsried ,
Germany .
[3]
[4]
[5]
Since 2017, Mahamid has been a
group leader at the
European Molecular Biology Laboratory in
Heidelberg , Germany.
[6]
[7]
[8]
[9]
[10]
[11]
Mahamid's research is based on the development of new methods for
cryo-electron tomography (cryo-ET), which is a technique for high-resolution 3D imaging of cellular machinery in its natural state. Mahamid played a key role in the development of the cryo-
focused ion beam (cryo-FIB) technique that facilitated the creation of "electron-transparent windows" in cells, enabling the observation of cellular structures and macromolecular complexes in their natural environment.
[12]
Mahamid is a well-known[
according to whom? ]
cell biologist ,
structural biologist , and electron microscopist. Hence, she is frequently invited to speak at seminars,
[13]
[14]
[15] workshops,
[16]
[17]
[18] and conferences
[19]
[20] in the field.
Mahamid is on the
editorial board of the
Journal of Structural Biology .
[21]
Awards and honours
References
^
a
b
https://www.academia-net.org/profile/julia-mahamid/77167
^
"Mahamid Group – In-cell structural analysis of phase separation and molecular crowding" .
^
https://en.bio-protocol.org/en/bpdetail?id=1575
^ Mahamid, Julia; Schampers, Ruud; Persoon, Hans; Hyman, Anthony A.; Baumeister, Wolfgang; Plitzko, Jürgen M. (2015).
"A focused ion beam milling and lift-out approach for site-specific preparation of frozen-hydrated lamellas from multicellular organisms" . Journal of Structural Biology . 192 (2): 262–269.
doi :
10.1016/j.jsb.2015.07.012 .
PMID
26216184 .
^ Mahamid, Julia; Pfeffer, Stefan; Schaffer, Miroslava; Villa, Elizabeth; Danev, Radostin; Kuhn Cuellar, Luis; Förster, Friedrich; Hyman, Anthony A.; Plitzko, Jürgen M.; Baumeister, Wolfgang (2016).
"Visualizing the molecular sociology at the HeLa cell nuclear periphery" . Science . 351 (6276): 969–972.
Bibcode :
2016Sci...351..969M .
doi :
10.1126/science.aad8857 .
PMID
26917770 .
S2CID
206645446 .
^ Toro-Nahuelpan, Mauricio; Zagoriy, Ievgeniia; Senger, Fabrice; Blanchoin, Laurent; Théry, Manuel; Mahamid, Julia (2020).
"Tailoring cryo-electron microscopy grids by photo-micropatterning for in-cell structural studies" . Nature Methods . 17 (1): 50–54.
doi :
10.1038/s41592-019-0630-5 .
PMC
6949126 .
PMID
31740821 .
^ Lucas, Bronwyn A.; Himes, Benjamin A.; Xue, Liang; Grant, Timothy; Mahamid, Julia; Grigorieff, Nikolaus (2021).
"Locating macromolecular assemblies in cells by 2D template matching with cisTEM" . eLife . 10 : e68946.
doi :
10.7554/eLife.68946 .
PMC
8219381 .
PMID
34114559 .
^ Goetz, Sara K.; Fung, Herman KH; Klumpe, Sven; Zagoriy, Ievgeniia; Hampoelz, Bernhard; Zhang, Xiaojie; Erdmann, Philipp S.; Baumbach, Janina; Müller, Christoph W.; Beck, Martin; Plitzko, Jürgen M.; Mahamid, Julia (2021).
"A modular platform for automated cryo-FIB workflows" . eLife . 10 .
doi :
10.7554/eLife.70506 .
PMC
8769651 .
PMID
34951584 .
^ Jawerth, Louise; Fischer-Friedrich, Elisabeth; Saha, Suropriya; Wang, Jie; Franzmann, Titus; Zhang, Xiaojie; Sachweh, Jenny; Ruer, Martine; Ijavi, Mahdiye; Saha, Shambaditya; Mahamid, Julia; Hyman, Anthony A.; Jülicher, Frank (2020).
"Protein condensates as aging Maxwell fluids" . Science . 370 (6522): 1317–1323.
Bibcode :
2020Sci...370.1317J .
doi :
10.1126/science.aaw4951 .
PMID
33303613 .
S2CID
226035825 .
^ Allegretti, Matteo; Zimmerli, Christian E.; Rantos, Vasileios; Wilfling, Florian; Ronchi, Paolo; Fung, Herman K. H.; Lee, Chia-Wei; Hagen, Wim; Turoňová, Beata; Karius, Kai; Börmel, Mandy; Zhang, Xiaojie; Müller, Christoph W.; Schwab, Yannick; Mahamid, Julia; Pfander, Boris; Kosinski, Jan; Beck, Martin (2020).
"In-cell architecture of the nuclear pore and snapshots of its turnover" . Nature . 586 (7831): 796–800.
Bibcode :
2020Natur.586..796A .
doi :
10.1038/s41586-020-2670-5 .
hdl :
21.11116/0000-0006-F3B5-B .
PMID
32879490 .
S2CID
221462632 .
^ o'Reilly, Francis J.; Xue, Liang; Graziadei, Andrea; Sinn, Ludwig; Lenz, Swantje; Tegunov, Dimitry; Blötz, Cedric; Singh, Neil; Hagen, Wim J. H.; Cramer, Patrick; Stülke, Jörg; Mahamid, Julia; Rappsilber, Juri (2020).
"In-cell architecture of an actively transcribing-translating expressome" . Science . 369 (6503): 554–557.
Bibcode :
2020Sci...369..554O .
doi :
10.1126/science.abb3758 .
PMC
7115962 .
PMID
32732422 .
^
"Julia Mahamid receives EMBO Gold Medal 2023 – Press releases – EMBO" . 6 June 2023.
^
"CSSB Seminar Series - JULIA MAHAMID" .
^
"Female Rising Stars, Dr. Julia Mahamid, Group Leader, Structural and Computational Biology Unit, European Molecular Biology Laboratory, Heidelberg, Germany" .
^
"CryoEM Seminar @ITQB NOVA - Julia Mahamid" .
^
"iNEXT-Discovery hands-on workshop: cryo-FIB lamella preparation & cryo electron tomography - Sciencesconf.org" . inextfibet.sciencesconf.org . Retrieved 27 November 2023 .
^
"In situ structural biology: From cryo-EM to multi-scale modelling – Course and Conference Office" .
^
"Cryo-EM in academia and industry – Course and Conference Office" .
^
"2023 Three Dimensional Electron Microscopy Conference GRC" .
^
"Seeing is Believing: Imaging the Molecular Processes of Life – Course and Conference Office" .
^
"Julia Mahamid, PhD - Editorial Board - Journal of Structural Biology - Journal - Elsevier" .
^
https://erc.europa.eu/sites/default/files/document/file/erc_2017_stg_results_ls.pdf
^
"In situ Structural Analysis of Molecular Crowding and Phase Separation | 3DCellPhase- Project | Fact Sheet | H2020" .
^ Marx, Vivien (2021).
"Julia Mahamid" . Nature Methods . 18 (2): 117.
doi :
10.1038/s41592-021-01063-0 .
PMID
33542512 .
S2CID
231820823 .
^
"Hybrid Technologies for Structural Cell Biology at Near-Atomic Resolution" .
^
"Illuminating protein complexes in cells" . 18 June 2021.
^
"EMBO Gold Medal 2023 awarded to ERC grantee" .
International National Academics