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John R. Yates
Alma mater University of Maine
University of Virginia
Known for Mass Spectrometry
AwardsBiemann Medal (2004)
Ralph N. Adams Award in Bioanalytical Chemistry (2015)
ACS Award in Analytical Chemistry (2015)
John B. Fenn Award (2019)
Scientific career
Fields Chemist
Institutions The Scripps Research Institute

John R. Yates III is an American chemist and Ernest W. Hahn Professor in the Departments of Molecular Medicine and Neurobiology at The Scripps Research Institute in La Jolla, California.

His work is focused on developing tools and in proteomics and he specializes in mass spectrometry. He is best known for the development of the SEQUEST algorithm for automated peptide sequencing [1] and Multidimensional Protein Identification Technology (MudPIT) [2] and data independent analysis (DIA). [3] His laboratory has made important contributions to understanding the biochemical mechanisms behind the failure of DF508 cystic fibrosis ion transport regulator (CFTR) to mature. [4] [5]

References

  1. ^ Eng, Jimmy K.; McCormack, Ashley L.; Yates, John R. (November 1994). "An approach to correlate tandem mass spectral data of peptides with amino acid sequences in a protein database". Journal of the American Society for Mass Spectrometry. 5 (11): 976–989. doi: 10.1016/1044-0305(94)80016-2. ISSN  1044-0305. PMID  24226387.
  2. ^ Washburn, Michael P.; Wolters, Dirk; Yates, John R. (March 2001). "Large-scale analysis of the yeast proteome by multidimensional protein identification technology". Nature Biotechnology. 19 (3): 242–247. doi: 10.1038/85686. ISSN  1087-0156. PMID  11231557. S2CID  16796135.
  3. ^ Venable, John D; Dong, Meng-Qiu; Wohlschlegel, James; Dillin, Andrew; Yates, John R (2004). "Automated approach for quantitative analysis of complex peptide mixtures from tandem mass spectra". Nature Methods. 1 (1): 39–45. doi: 10.1038/nmeth705. ISSN  1548-7091. PMID  15782151. S2CID  9780065.
  4. ^ Pankow, Sandra; Bamberger, Casimir; Calzolari, Diego; Martínez-Bartolomé, Salvador; Lavallée-Adam, Mathieu; Balch, William E.; Yates, John R. (2015-12-24). "∆F508 CFTR interactome remodelling promotes rescue of cystic fibrosis". Nature. 528 (7583): 510–516. Bibcode: 2015Natur.528..510P. doi: 10.1038/nature15729. ISSN  0028-0836. PMC  4826614. PMID  26618866.
  5. ^ Pankow, Sandra; Bamberger, Casimir; Yates, John R. (2019). "A posttranslational modification code for CFTR maturation is altered in cystic fibrosis". Science Signaling. 12 (562): eaan7984. doi: 10.1126/scisignal.aan7984. ISSN  1945-0877. PMC  6464640. PMID  30600261.

External links