Joe Cain (1832–1904) was a Native American.
Joe or Joseph Cain may also refer to:
- Joe Cain (American football) (born 1965), American football linebacker
- Joe Cain (historian of science) (born 1964)
- Joe Cain (rugby union) for Leicester Tigers
- Joseph Alexander Cain (1920–1980), American painter, art educator and critic
- Joseph Hilliard Cain Sr. (1892–1962), American military officer and politician
See also
- Joe Kane, American author
- Joseph Kane (disambiguation)
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disambiguation page lists articles about people with the same name.
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