Jane Clarke may refer to:
- Jane Clarke (scientist) (born 1950), professor of molecular biophysics at the University of Cambridge
- Jane E. Clarke (born 1954), children's author
- Jane Clarke (media industry)
- Jane Clarke (poet), from Co. Roscommon, Republic of Ireland
- Jane Clarke (EastEnders) fictional character better known as Jane Beale.
See also
- Mary Jane Clarke (1862–1910), suffragette
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