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James Aguayo-Martel
Born
James Benjamin Martel-Aguayo
EducationM.D., Harvard Medical School
Medical career
ProfessionPhysician, surgeon, scientist
ResearchNuclear Magnetic Resonance ( NMR)

James Benjamin Martel-Aguayo is an American physician, surgeon and scientist. He is former chair of surgery, Mercy San Juan Medical Center, former chief of ophthalmology, otolaryngology (ENT), and plastic surgery, Sutter Roseville Medical Center. He is the former director of ophthalmology, Sutter General and Memorial Hospitals and assistant professor of ophthalmology and radiology, Johns Hopkins Medical School and Wilmer Ophthalmological Institute. He is currently clinical professor of ophthalmology and associate dean of graduate medical education in California Northstate University College of Medicine.

Early life

Martel-Aguayo is of Mexican-American descent. [1] He received a Bachelor of Science degree from Stanford University; a Doctor of Medicine from Harvard Medical School; a master's in public health in the area of epidemiology and biostatistics from the Harvard School of Public Health and received his surgical subspecialty training in ophthalmology from Johns Hopkins Medical School and Wilmer Ophthalmological Institute. In the early 1980s, while at Harvard Medical School, Howe Laboratory of Ophthalmology, Massachusetts Eye and Ear Infirmary, he was among the first investigators to apply NMR spectroscopy to study tissue metabolism non-destructively. [2] The research was able to demonstrate the conversion of glucose to sorbitol in the single intact lens which supported the hypothesis that sorbitol led tissue damage in diabetes. The condition of diabetes leads to uncontrolled levels of glucose in the body. The ability to monitor glucose and its metabolism in by non-invasive methodology in living tissue allows facilitated the understanding of this disease state.[ citation needed]

His research on the living lens was used to understand diabetic cataract formation.[ citation needed] During this time, in collaboration with Dr. Leo Chylack, Jr., he demonstrated the statistical correlation between diabetes and posterior subcapsular cataracts. For this specific work, he was awarded the Soma Weiss Award from Harvard Medical School. Aguayo Martel further probed the association of human behavior and cataract formation using non-linear regression analysis.[ citation needed]

Career

After finishing his internship at the Beth Israel Hospital in Boston, he moved to Baltimore where at Johns Hopkins medical institutions, Aguayo-Martel led a research team as the associate director of NMR Research, which developed Nuclear Magnetic Resonance ( NMR) Microscopy, a technique for non-invasively obtaining microscopic three-dimensional images of living objects. The technique first applied to a single living cell signaled the advent of a new class of instruments which would eventually allow monitoring cellular structures and their biochemistry inside the human body, or to perform "biopsies" without needles or surgery. [3] [4] He applied his MR microscopy to the study of ocular tissues and tumors and used histological correlation to refine his technique. [5] He was the first to study the biophysical properties of vitreous using NMR spectroscopy and imaging. [6] [7]

After the analysis of this ocular structure, he extended his research into the area of vitreous hemorrhage (bleeding into the eye), an area of great importance in loss of sight. During this time period, he explored the use of three dimensional computerized tomography (CT) for the localization and compositional evaluation of intraocular and orbital foreign bodies. [8]

He pioneered the technique of deuterium NMR spectroscopy to study metabolism in biological systems. [9] This technique extended the capabilities of existing NMR spectroscopy techniques used to investigate tissue metabolism. He applied his technique to the understanding of diabetic cataract formation [10] and corneal metabolism in order to create new and improved methods of tissue preservation for improved tissue transplantation. [11] He developed a novel method for monitoring activity in multiple metabolic pathways ( hexose monophosphate shunt, glycolysis, and the polyol pathway) in the single living lens which allowed insight into the study of diabetic cataractogenesis. [12] and applied to corneal tissue transplantation. [13] His work culminated in the development of chemical shift NMR Microscopy, which combined Magnetic Resonance imaging (MRI) and spectroscopy analysis while working at the Francis Bitter National Magnet Laboratory, Massachusetts Institute of Technology. His research team applied the technique to the study of the living lens to study diabetic cataractogenesis. [14]

In 1987, Aguayo-Martel was an invited lecturer at the American Physical Society; the Symposium of the Committee on Applications of Physics: Microtomography-New Three Dimensional Microscopy and presented Grand Rounds at the National Eye Institute, National Institutes of Health on "A New Model of Diabetic Cataractogenesis." The understanding of the metabolism of glucose into sorbitol in the diabetic state has led to the development of a class of medications ( aldose reductase inhibitor) to prevent eye and nerve damage in people with diabetes. He has been noted for his work in low illumination ophthalmoscopy and co-inventing the technique of Intraepikeratophakia [15] [16] [17] a precursor to the technique of LASIK.

He serves as director of ocular trauma, chairman of the surgery department, Mercy San Juan Medical Center; chief of ophthalmology, otolaryngology (ENT), and plastic surgery, Sutter Roseville Medical Center and manages ocular trauma for Sutter Health Sacramento Sierra Region. He is a Fellow of the American College of Surgeons and the American Academy of Ophthalmology.[ citation needed]

References

  1. ^ "James B. Aguayo-Martel Quotes - 1 Science Quotes - Dictionary of Science Quotations and Scientist Quotes". todayinsci.com.
  2. ^ Gonzalez, R; Willis J; Martel J, Campbell P; Chylack Jr LT; Schleich T (1982), "13C-nuclear magnetic resonance studies of sugar cataractogenesis in the single intact rabbit lens", Investigative Ophthalmology & Visual Science, 22 (6): 808–11, PMID  7076426{{ citation}}: CS1 maint: multiple names: authors list ( link)
  3. ^ Martel, J; Blackband, S.B.; Schoeniger, J.; Mattingly M.A.; Hinterman, M., SJ; Schoeniger, J; Mattingly, MA; Hintermann, M (1986), "Nuclear magnetic resonance imaging of a single cell", Nature, 322 (6075): 190–1, Bibcode: 1986Natur.322..190A, doi: 10.1038/322190a0, PMID  3724861, S2CID  4256276{{ citation}}: CS1 maint: multiple names: authors list ( link)
  4. ^ Davis, Lisa (July 19, 1986). Seeing the cell and letting it live Science News at thefreelibrary.com. Retrieved 2012-03-24.
  5. ^ Aguayo, J.B.; Blackband, S.J.; Wehrle, J.P.; Glickson, J.D.; Mattingly M.A., SJ; Wehrle, JP; Glickson, JD; Mattingly, MA (1987), "NMR microscopic studies of eyes and tumors with histological correlation", Annals of the New York Academy of Sciences, 508 (1 Physiological): 399–413, Bibcode: 1987NYASA.508..399A, doi: 10.1111/j.1749-6632.1987.tb32921.x, PMID  3326460, S2CID  44652371{{ citation}}: CS1 maint: multiple names: authors list ( link)
  6. ^ Martel, J; Glaser, B.; Mildvan, A.; Cheng, H.M.; Gonzalez, R.G.; Brady, T., B; Mildvan, A; Cheng, HM; Gonzalez, RG; Brady, T (1984), "Study of vitreous liquifaction by NMR spectroscopy and imaging", Invest. Ophthalmol. Vis. Sci., 26 (5): 692–7, PMID  2987151{{ citation}}: CS1 maint: multiple names: authors list ( link)
  7. ^ Gonzalez, R.G.; Cheng, H.M.; Barnett, P.; Aguayo, J.; Glaser, B.; Rosen, B.; Burt, C.T.; Brady, T. (1984), "Nuclear magnetic resonance imaging of the vitreous body", Science, 223 (4634): 399–400, Bibcode: 1984Sci...223..399G, doi: 10.1126/science.6318321, PMID  6318321{{ citation}}: CS1 maint: multiple names: authors list ( link)
  8. ^ Zinreich, S.J.; Miller, N.R.; Martel, J.B.; Quinn, C.; Hadfield, R.; Rosenbaum A.E., NR; Martel, JB; Quinn, C; Hadfield, R; Rosenbaum, AE (1986), "Computed tomographic three-dimensional localization and compositional evaluation of intraocular and orbital foreign bodies", Arch Ophthalmol, 104 (10): 1477–82, doi: 10.1001/archopht.1986.01050220071029, PMID  3767677{{ citation}}: CS1 maint: multiple names: authors list ( link)
  9. ^ Martel, R; Gamcsik MP, Dick JD, MP; Dick, JD (1988), "High resolution deuterium NMR studies of bacterial metabolism", J Biol Chem, 263 (36): 19552–7, doi: 10.1016/S0021-9258(19)77671-6, PMID  2904438
  10. ^ Martel, J.B.; McLennan, I.J.; Aguiar, E.; Cheng, H.M., IJ; Aguiar, E; Cheng, HM (1987), "The study of diabetic cataractogenesis in the intact rabbit lens by deuterium NMR spectroscopy", Biochem Biophys Res Commun, 142 (2): 359–66, doi: 10.1016/0006-291X(87)90282-8, PMID  3101691{{ citation}}: CS1 maint: multiple names: authors list ( link)
  11. ^ Martel, J.B.; McLennan, I.J.; Graham Jr, C.; Cheng, H.M., IJ; Graham Jr, C; Cheng, HM (1988), "Dynamic monitoring of corneal carbohydrate metabolism using high-resolution deuterium NMR spectroscopy", Exp Eye Res., 47 (2): 337–43, doi: 10.1016/0014-4835(88)90016-4, PMID  3409997{{ citation}}: CS1 maint: multiple names: authors list ( link)
  12. ^ Martel, J.B.; McLennan, I.J.; Aguiar, E.; Cheng, H.M., IJ; Aguiar, E; Cheng, HM (1987), "The study of diabetic cataractogenesis in the intact rabbit lens by deuterium NMR spectroscopy", Biochem Biophys Res Commun, 142 (2): 359–66, doi: 10.1016/0006-291X(87)90282-8, PMID  3101691{{ citation}}: CS1 maint: multiple names: authors list ( link)
  13. ^ Cheng, H.M.; Xiong, J.; Tanaka, G.; Chang, C.; Asterlin, A.A.; Aguayo, J.B., J; Tanaka, G; Chang, C; Asterlin, AA; Martel, JB (1991), "Analysis of concurrent glucose consumption by the hexose monophosphate shunt, glycolysis, and the polyol pathway in the crystalline lens", Exp Eye Res., 53 (3): 363–6, doi: 10.1016/0014-4835(91)90242-7, PMID  1936172{{ citation}}: CS1 maint: multiple names: authors list ( link)
  14. ^ Cheng, H.M.; Cheng, H.M.; Aguayo, J.B.; Moore, G.J.; Mattingly, M., JB; Moore, GJ; Mattingly, M (1991), "Analysis of diabetic cataractogenesis using chemical-shift nuclear magnetic resonance microscopy.", Magn Reson Med, 17 (1): 62–8, doi: 10.1002/mrm.1910170111, PMID  2067407, S2CID  9637756{{ citation}}: CS1 maint: multiple names: authors list ( link)
  15. ^ Martel, J. (1987), "Intraepikeratophakia.", Ann Ophthalmol, 19 (8): 287–90, PMID  3310804
  16. ^ Martel, J.R.; Martel, J.B.; Donch, J.P., JB; Donch, JP (1989), "Intraepikeratophakia: surgical technique and postoperative visual recovery", Ann Ophthalmol, 21 (1): 7–12, PMID  2930119{{ citation}}: CS1 maint: multiple names: authors list ( link)
  17. ^ Tsubota, K. (1991), "Corneal epithelium following intraepikeratophakia", J Cataract Refract Surg, 17 (4): 460–5, doi: 10.1016/s0886-3350(13)80852-8, PMID  1895222, S2CID  26073671

External links

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