IFITM5 | |||||||||||||||||||||||||||||||||||||||||||||||||||
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Aliases | IFITM5, interferon induced transmembrane protein 5, BRIL, DSPA1, Hrmp1, OI5, fragilis4 | ||||||||||||||||||||||||||||||||||||||||||||||||||
External IDs | OMIM: 614757; MGI: 1934923; HomoloGene: 14210; GeneCards: IFITM5; OMA: IFITM5 - orthologs | ||||||||||||||||||||||||||||||||||||||||||||||||||
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Wikidata | |||||||||||||||||||||||||||||||||||||||||||||||||||
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Interferon-induced transmembrane protein 5 is a gene that encodes a membrane protein thought to play a role in bone mineralization.
The gene is located on the short arm of the Crick strand of chromosome 11 (11p15.5). It is located with a cluster of interferon inducible genes but is itself not interferon inducible. The gene is 1,327 bases in length and encodes a protein of 132 amino acids with a predicted molecular weight of 14378 daltons. Expression in adults is bone specific and highest in osteoblasts. [ citation needed]
The homolog in the mouse is located on chromosome 7. A homolog is also known to be present in lizards.[ citation needed]
The gene first appeared in bony fish and its bone specific expression appears to be limited to therian mammals.[ citation needed]
The protein has two transmembrane domains. It associates with FK506 binding protein 11. [5]
Mutations in the gene are associated with osteogenesis imperfecta type 5. [6]