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Chemical compound
ICI-85966
Other names Stilbostat; Diethylstilbestrol (DES) bis(di(2-chloroethyl)carbamate)
[4-[(E )-4-[4-[Bis(2-chloroethyl)carbamoyloxy]phenyl]hex-3-en-3-yl]phenyl] N ,N -bis(2-chloroethyl)carbamate
CAS Number
PubChem
CID
ChemSpider
UNII
Formula C 28 H 34 Cl 4 N 2 O 4
Molar mass 604.39 g·mol−1 3D model (
JSmol )
CC/C(=C(/CC)\C1=CC=C(C=C1)OC(=O)N(CCCl)CCCl)/C2=CC=C(C=C2)OC(=O)N(CCCl)CCCl
InChI=1S/C28H34Cl4N2O4/c1-3-25(21-5-9-23(10-6-21)37-27(35)33(17-13-29)18-14-30)26(4-2)22-7-11-24(12-8-22)38-28(36)34(19-15-31)20-16-32/h5-12H,3-4,13-20H2,1-2H3/b26-25+
Key:BOIZOYRDXIYMCY-OCEACIFDSA-N
ICI-85966 (former tentative brand name Stilbostat ), also known as diethylstilbestrol (DES) bis(di(2-chloroethyl)carbamate) , is a
synthetic ,
nonsteroidal
estrogen and
cytostatic
antineoplastic agent of the
stilbestrol group and a
nitrogen mustard
ester of
diethylstilbestrol (DES) which was developed for the treatment of
breast cancer and
prostate cancer but was never marketed (possibly due to the toxicity of DES).
[1]
[2]
[3]
[4]
[5]
See also
References
^ J. Elks (14 November 2014).
The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies . Springer. p. 397.
ISBN
978-1-4757-2085-3 .
^ Zimel H, Broder D, Zimel A (1973). "[Therapeutic effects of the preparation "Stilbostat" in advanced stages of breast cancer after the menopause]". Stud Cercet Endocrinol (in Romanian). 24 (3): 211–9.
PMID
4703920 .
^ Görlich M, Heise E (1976). "Contribution to the mechanism of Stilbostat action". Neoplasma . 23 (4): 363–9.
PMID
1004653 .
^ Zimel H, Mogos I, Maltezeanu G (1977). "Estimation of StilbostatR treatment efficiency in breast cancer by thermography". Neoplasma . 24 (5): 553–7.
PMID
927612 .
^ Zimel H, Bocancea D (1974). "Treatment of prostatic carcinoma with Stilbostat". Neoplasma . 21 (1): 101–8.
PMID
4596007 .
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