Dabie bandavirus, also called SFTS virus, is a
tick-borne virus in the genus Bandavirus in the family Phenuiviridae, order Bunyavirales.[2] The clinical condition it caused is known as
severe fever with thrombocytopenia syndrome (SFTS).[2] SFTS is an emerging infectious disease that was first described in northeast and central China 2009 and now has also been discovered in Japan, South Korea, Vietnam and Taiwan in 2015. SFTS has a fatality rate of 12% and as high as over 30% in some areas. The major clinical symptoms of SFTS are fever, vomiting, diarrhea, multiple organ failure, thrombocytopenia (low platelet count), leukopenia (low white blood cell count) and elevated liver enzyme levels. Another outbreak occurred in East China in the early half of 2020.
History
In 2009, Xue-jie Yu and colleagues isolated the SFTS virus (SFTSV) from SFTS patients’ blood.[2]
Genome
The genome has been sequenced.[2] There are three segments—large (L), medium (M) and small (S). Five proteins have been identified—an
RNA dependent RNA polymerase (RdRp), a glycoprotein N (Gn), a glycoprotein C (Gc), a nuclear protein (NP) and a non structural protein (NSs).[citation needed]
The L segment encodes the RNA polymerase with 2084 amino acid residues.[citation needed]
The S segment has 1746 nucleotides of ambisense RNA encoding two proteins, the N and NSs proteins. These lie in opposite orientations and are separated by a 54 nucleotide intergenic region.[3]
Evolution
Five genotypes (A–E) have been identified.[4] Strains from
China could be grouped into all five genotypes while isolates from
South Korea lay in three (types A, D and E) and those from
Japan only in one (type E). The virus appears to have originated in the
Dabie Mountains in central China between 1918 and 1995.[citation needed]
Among bunyaviruses, it appears to be more closely related to the
Uukuniemi virus serogroup than to the Sandfly fever group.[2] It is a member of the Bhanja virus serocomplex.[5]
This virus has been found in the Chinese provinces of
Anhui,
Henan,
Hubei,
Jiangsu,
Liaoning and
Shandong. SFTS occurs in rural areas, from March to November, and a majority of cases are found from April to July.[citation needed]
The virus has also been found in South Korea, Japan, Vietnam and Taiwan.[11][12][13]
^Suh JH, Kim HC, Yun SM, Lim JW, Kim JH, Chong ST, et al. (May 2016). "Detection of SFTS Virus in Ixodes nipponensis and Amblyomma testudinarium (Ixodida: Ixodidae) Collected From Reptiles in the Republic of Korea". J. Med. Entomol. 53 (3): 584–590.
doi:
10.1093/jme/tjw007.
PMID26957392.