HuS-E/2 cells are
immortalized primary human
hepatocytes that were isolated from the discarded old
liver tissue obtained from a 9-year-old male patient with primary
hyperoxaluria (after the approval of ethical committee and required written consent) who had undergone
liver transplantation to receive a new liver.[1] Hepatocytes were transduced with
hTERT and HPV-E6E7
oncogenes. This immortalized hepatocyte cell line showed similar characteristics to primary hepatocytes, and was beneficial in the study of
Hepatitis C and
B viruses.[1][2][3][4]