Hephaestion (356 BC–324 BC) was Alexander's celebrated friend and general.

Hephaestion or Hephaistion may also refer to:

• Hephaestion (beetle), a genus of beetles
• Hephaestion (grammarian) of Alexandria, who flourished in the age of the Antonines
• Hephestion (horse) (foaled 1807), a British Thoroughbred racehorse
• Hephaestion of Thebes, 5th century astrologer

See also

• Hephaestin, a protein involved in the metabolism and homeostasis of iron
• Hephaesteion, the Temple of Hephaestus, Athens, Greece

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