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| Company type | Public |
|---|---|
| Nasdaq: HTBX [1] | |
| Industry | Biotechnology |
| Founded | 2008 |
| Headquarters | Morrisville, North Carolina [2] |
Area served | Morrisville, North Carolina
[2] New Brunswick, New Jersey [2] San Antonio, Texas [2] |
Key people | Jeffrey Wolf ( Founder and CEO) |
| Products | HS-110, HS-130, PTX-35 and COVID-19 program |
| Website |
www |
Heat Biologics Inc. is a US biotechnology company focused on the field of immunotherapy. Heat Biologics was founded by Jeff Wolf and Eckhard Podack, in conjunction with the University of Miami and Seed-One Ventures. [3] The company is based in Morrisville, North Carolina. [2]
History
In 2008, Heat Biologics was founded by Jeff Wolf and Eckhard Podack, in conjunction with the University of Miami and Seed-One Ventures. [3] The company relocated to North Carolina in 2011. [2] NCBiotech provided $225,000 of initial funding the same year. [2]
On July 24, 2013, Heat Biologics stock went public on NASDAQ under ticker symbol HTBX. [1]
In 2017, Heat Biologics acquired an 80% controlling interest in Pelican Therapeutics. [4]
Morrisville, North Carolina became the company's headquarters in 2019. [2]
In 2020, the Leonard M. Miller School of Medicine collaborated with Heat Biologics to develop a COVID-19 vaccine using gp-96 to express antigens associated with COVID-19. [5]
In 2021, Heat Biologics began Phase 2 clinical trials for a new non-small cell lung cancer treatment (HS-110). It also initiated a Phase 1 trial for HS-130, its off-the-shelf cell line engineered to stimulate T-cells to assist in immune response to disease. [2]
Pipeline products
HS-110
HS-110, also called viagenpumatucel-L, is in Phase II in NSCLC, in combination with cyclophosphamide. Another Phase I study is combining HS 110 with nivolumab and other checkpoint inhibitors. [6]
HS-130
HS-130 is in Phase I clinical trial for patients with solid tumors. HS-130 is an allogeneic (“off-the-shelf”) cell line engineered to express OX40 ligand fusion protein (OX40L-Fc). OX40 ligand is a key co-stimulator of T cells that augments antigen-specific CD8+ T cell responses. [7]
COVID-19 Vaccine
The company initiated a COVID-19 vaccine collaboration with the University of Miami in March 2020 using their gp96 platform which activates the human immune system to combat infectious diseases with the potential of generating long-term immune responses. [8]
PTX-35
PTX-35 is in Phase I clinical trial for patients with solid tumors. PTX-35 is a potential first-in-class T cell co-stimulator targeting TNFRSF25 (Death Receptor 3). Favorable safety profile was demonstrated in mice and non-human primates. PTX-35's development plan focuses on cancer immunotherapy. [9]
References
- ^ a b "Heat Biologics, Inc. Announces Closing of Initial Public Offering of 2,500,000 Shares of Common Stock". Heatbio.com. July 29, 2013. Archived from the original on 2016-03-04. Retrieved 1 January 2016.
- ^ a b c d e f g h i Bryant Haskins (June 24, 2021). "Heat Biologics To Double Size of Morrisville R&D Center". North Carolina Biotechnology Center.
- ^ a b Howard Cohen (October 15, 2015). "Dr. Eckhard Podack, University of Miami cancer researcher, dies at 72". Miami Herald.
- ^ Allan Maurer (November 3, 2020). "'Synergy' Behind Heat Biologics/Pelican deal is Key to Immunology". North Carolina Biotechnology Center.
- ^ Richard Westlund (March 18, 2020). "Immunology researchers at the University of Miami Miller School of Medicine are collaborating with North Carolina-based Heat Biologics, Inc. to develop a vaccine for the novel coronavirus COVID-19". Miller School of Medicine.
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^ Heat Biologics (2020-01-24).
"A Phase 2, Multicenter, Randomized Study to Evaluate the Safety and Efficacy of Viagenpumatucel-L (HS-110) in Combination With Low Dose (Metronomic) Cyclophosphamide Versus Chemotherapy Alone in Patients With Non-Small Cell Lung Adenocarcinoma After Failure of Two or Three Previous Treatment Regimens for Advanced Disease".
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^ Heat Biologics (2020-09-14).
"A Phase I, First-in-human, Dose-escalation Study to Evaluate the Safety and Immunologic Response After Administration of HS-130 in Combination With HS-110 (Viagenpumatucel-L) in Patients With Solid Tumors Refractory to Standard Care".
{{ cite journal}}: Cite journal requires|journal=( help) - ^ "Heat Biologics and University of Miami - gp96-Ig-S". GEN - Genetic Engineering and Biotechnology News. 2020-05-18. Retrieved 2021-01-12.
- ^ "Heat Biologics Announces First Patient Treated in First-in-Human Clinical Trial of PTX-35". BioSpace. Retrieved 2021-01-12.