From Wikipedia, the free encyclopedia
Protein-coding gene in the species Homo sapiens
H2BC1 Available structures
PDB Ortholog search:
PDBe
RCSB List of PDB id codes
3WKJ
Identifiers
Aliases
H2BC1 , H2BFU, STBP, TSH2B, TSH2B.1, bA317E16.3, TH2B, histone cluster 1, H2ba, histone cluster 1 H2B family member a, hTSH2B, HIST1H2BA, H2B clustered histone 1External IDs
OMIM :
609904
MGI :
2448375
HomoloGene :
69356
GeneCards :
H2BC1
Wikidata
Histone H2B type 1-A is a
protein that in humans is encoded by the HIST1H2BA
gene .
[5]
[6]
[7]
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a testis/sperm-specific member of the histone H2B family. Transcripts from this gene contain a palindromic termination element.
[7]
References
^
a
b
c
GRCh38: Ensembl release 89: ENSG00000146047 –
Ensembl , May 2017
^
a
b
c
GRCm38: Ensembl release 89: ENSMUSG00000050799 –
Ensembl , May 2017
^
"Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^
"Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^ Marzluff WF, Gongidi P, Woods KR, Jin J, Maltais LJ (Oct 2002). "The human and mouse replication-dependent histone genes". Genomics . 80 (5): 487–98.
doi :
10.1016/S0888-7543(02)96850-3 .
PMID
12408966 .
^ Zalensky AO, Siino JS, Gineitis AA, Zalenskaya IA, Tomilin NV, Yau P, Bradbury EM (Nov 2002).
"Human testis/sperm-specific histone H2B (hTSH2B). Molecular cloning and characterization" . J Biol Chem . 277 (45): 43474–80.
doi :
10.1074/jbc.M206065200 .
PMID
12213818 .
^
a
b
"Entrez Gene: HIST1H2BA histone cluster 1, H2ba" .
Further reading
El Kharroubi A, Piras G, Zensen R, Martin MA (1998).
"Transcriptional Activation of the Integrated Chromatin-Associated Human Immunodeficiency Virus Type 1 Promoter" . Mol. Cell. Biol . 18 (5): 2535–44.
doi :
10.1128/mcb.18.5.2535 .
PMC
110633 .
PMID
9566873 .
Deng L, de la Fuente C, Fu P, et al. (2001).
"Acetylation of HIV-1 Tat by CBP/P300 increases transcription of integrated HIV-1 genome and enhances binding to core histones" . Virology . 277 (2): 278–95.
doi :
10.1006/viro.2000.0593 .
PMID
11080476 .
Deng L, Wang D, de la Fuente C, et al. (2001).
"Enhancement of the p300 HAT activity by HIV-1 Tat on chromatin DNA" . Virology . 289 (2): 312–26.
doi :
10.1006/viro.2001.1129 .
PMID
11689053 .
Strausberg RL, Feingold EA, Grouse LH, et al. (2003).
"Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–903.
Bibcode :
2002PNAS...9916899M .
doi :
10.1073/pnas.242603899 .
PMC
139241 .
PMID
12477932 .
Mungall AJ, Palmer SA, Sims SK, et al. (2003).
"The DNA sequence and analysis of human chromosome 6" . Nature . 425 (6960): 805–11.
Bibcode :
2003Natur.425..805M .
doi :
10.1038/nature02055 .
PMID
14574404 .
Lusic M, Marcello A, Cereseto A, Giacca M (2004).
"Regulation of HIV-1 gene expression by histone acetylation and factor recruitment at the LTR promoter" . EMBO J . 22 (24): 6550–61.
doi :
10.1093/emboj/cdg631 .
PMC
291826 .
PMID
14657027 .
Gerhard DS, Wagner L, Feingold EA, et al. (2004).
"The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)" . Genome Res . 14 (10B): 2121–7.
doi :
10.1101/gr.2596504 .
PMC
528928 .
PMID
15489334 .
Li A, Maffey AH, Abbott WD, et al. (2005). "Characterization of nucleosomes consisting of the human testis/sperm-specific histone H2B variant (hTSH2B)". Biochemistry . 44 (7): 2529–35.
doi :
10.1021/bi048061n .
PMID
15709765 .
Golebiowski F, Kasprzak KS (2007).
"Inhibition of core histones acetylation by carcinogenic nickel(II)" . Mol. Cell. Biochem . 279 (1–2): 133–9.
doi :
10.1007/s11010-005-8285-1 .
PMID
16283522 .
S2CID
25071586 .
Zhu B, Zheng Y, Pham AD, et al. (2006).
"Monoubiquitination of human histone H2B: the factors involved and their roles in HOX gene regulation" . Mol. Cell . 20 (4): 601–11.
doi :
10.1016/j.molcel.2005.09.025 .
PMID
16307923 .
Pavri R, Zhu B, Li G, et al. (2006).
"Histone H2B monoubiquitination functions cooperatively with FACT to regulate elongation by RNA polymerase II" . Cell . 125 (4): 703–17.
doi :
10.1016/j.cell.2006.04.029 .
PMID
16713563 .
S2CID
2614680 .
Kim SC, Sprung R, Chen Y, et al. (2006).
"Substrate and functional diversity of lysine acetylation revealed by a proteomics survey" . Mol. Cell . 23 (4): 607–18.
doi :
10.1016/j.molcel.2006.06.026 .
PMID
16916647 .