From Wikipedia, the free encyclopedia
Protein-coding gene in the species Homo sapiens
Histone H2A.Z is a
protein that in humans is encoded by the H2AZ1
gene .
[5]
[6]
Histones are basic nuclear proteins that are responsible for the
nucleosome structure of the
chromosomal fiber in
eukaryotes . Nucleosomes consist of approximately 146 bp of DNA wrapped around a
histone octamer composed of pairs of each of the four core histones (
H2A ,
H2B ,
H3 , and
H4 ). The
chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. The H2AFZ gene encodes a replication-independent member of the histone H2A family that is distinct from other members of the family. Studies in mice have shown that this particular histone is required for embryonic development and indicate that lack of functional histone H2A leads to embryonic lethality.
[6]
Histone H2AZ is a
variant of histone H2A, and is used to mediate the thermosensory response, and is essential to perceive the ambient temperature. Nucleosome occupancy of H2A.Z decreases with temperature, and in vitro assays show that H2A.Z-containing nucleosomes wrap DNA more tightly than canonical H2A nucleosomes in
Arabidopsis .(Cell 140: 136–147, 2010) However, some of the other studies (Nat. Genet. 41, 941–945 and Genes Dev., 21, 1519–1529) have shown that incorporation of H2A.Z in nucleosomes, when it co-occurs with H3.3, makes them weaker. Positioning of H2A.Z containing nucleosomes around transcription start sites has now been shown to affect the downstream gene expression.
[7]
Recent evidence also points to a role for H2A.Z in repressing a subset of
ncRNAs , derepressing
CUTs , as well as mediation higher order chromatin structure formation.
[8]
References
^
a
b
c
GRCh38: Ensembl release 89: ENSG00000164032 –
Ensembl , May 2017
^
a
b
c
GRCm38: Ensembl release 89: ENSMUSG00000037894 –
Ensembl , May 2017
^
"Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^
"Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^ Hatch CL, Bonner WM (Oct 1990).
"The human histone H2A.Z gene. Sequence and regulation" . J Biol Chem . 265 (25): 15211–8.
doi :
10.1016/S0021-9258(18)77243-8 .
PMID
1697587 .
^
a
b
"Entrez Gene: H2AFZ H2A histone family, member Z" .
^ Bargaje R., Alam P., Patowary A., Sarkar M., Ali T., Gupta S., Garg M., Singh M., Purkanti R., Scaria V., Sivasubbu S., Brahmachari V., Pillai B. (2012) Proximity of H2A.Z containing nucleosome to the transcription start site influences gene expression levels in the mammalian liver and brain. Nucleic Acids Research (Epub ahead of print)Bargaje R, Alam MP, Patowary A, et al. (October 2012).
"Proximity of H2A.Z containing nucleosome to the transcription start site influences gene expression levels in the mammalian liver and brain" . Nucleic Acids Research . 40 (18): 8965–78.
doi :
10.1093/nar/gks665 .
PMC
3467062 .
PMID
22821566 .
^ Rege M (2015).
"Chromatin Dynamics and the RNA Exosome Function in Concert to Regulate Transcriptional Homeostasis" . Cell Reports . 13 (8): 1610–1622.
doi :
10.1016/j.celrep.2015.10.030 .
PMC
4662874 .
PMID
26586442 .
Further reading
Jason LJ, Moore SC, Lewis JD, et al. (2002). "Histone ubiquitination: a tagging tail unfolds?". BioEssays . 24 (2): 166–74.
doi :
10.1002/bies.10038 .
PMID
11835281 .
S2CID
39905043 .
Hatch CL, Bonner WM (1988).
"Sequence of cDNAs for mammalian H2A.Z, an evolutionarily diverged but highly conserved basal histone H2A isoprotein species" . Nucleic Acids Res . 16 (3): 1113–24.
doi :
10.1093/nar/16.3.1113 .
PMC
334740 .
PMID
3344202 .
Kato S, Sekine S, Oh SW, et al. (1995). "Construction of a human full-length cDNA bank". Gene . 150 (2): 243–50.
doi :
10.1016/0378-1119(94)90433-2 .
PMID
7821789 .
Hatch CL, Bonner WM (1995).
"Characterization of the proximal promoter of the human histone H2A.Z gene" . DNA Cell Biol. (Submitted manuscript). 14 (3): 257–66.
doi :
10.1089/dna.1995.14.257 .
PMID
7880446 .
Popescu N, Zimonjic D, Hatch C, Bonner W (1994).
"Chromosomal mapping of the human histone gene H2AZ to 4q24 by fluorescence in situ hybridization" . Genomics (Submitted manuscript). 20 (2): 333–5.
doi :
10.1006/geno.1994.1182 .
PMID
8020992 .
Hatch CL, Bonner WM (1996). "An upstream region of the H2AZ gene promoter modulates promoter activity in different cell types". Biochim. Biophys. Acta . 1305 (1–2): 59–62.
doi :
10.1016/0167-4781(95)00223-5 .
PMID
8605251 .
El Kharroubi A, Piras G, Zensen R, Martin MA (1998).
"Transcriptional Activation of the Integrated Chromatin-Associated Human Immunodeficiency Virus Type 1 Promoter" . Mol. Cell. Biol . 18 (5): 2535–44.
doi :
10.1128/mcb.18.5.2535 .
PMC
110633 .
PMID
9566873 .
Slachta CA, Jeevanandam V, Goldman B, et al. (2000).
"Coronary arteries from human cardiac allografts with chronic rejection contain oligoclonal T cells: persistence of identical clonally expanded TCR transcripts from the early post-transplantation period (endomyocardial biopsies) to chronic rejection (coronary arteries)" . J. Immunol . 165 (6): 3469–83.
doi :
10.4049/jimmunol.165.6.3469 .
PMID
10975868 .
Pasqualucci L, Neri A, Baldini L, et al. (2000). "BCL-6 mutations are associated with immunoglobulin variable heavy chain mutations in B-cell chronic lymphocytic leukemia". Cancer Res . 60 (20): 5644–8.
PMID
11059755 .
Deng L, de la Fuente C, Fu P, et al. (2001).
"Acetylation of HIV-1 Tat by CBP/P300 increases transcription of integrated HIV-1 genome and enhances binding to core histones" . Virology . 277 (2): 278–95.
doi :
10.1006/viro.2000.0593 .
PMID
11080476 .
Suto RK, Clarkson MJ, Tremethick DJ, Luger K (2001). "Crystal structure of a nucleosome core particle containing the variant histone H2A.Z". Nat. Struct. Biol . 7 (12): 1121–4.
doi :
10.1038/81971 .
PMID
11101893 .
S2CID
5966635 .
Bräuninger A, Yang W, Wacker HH, et al. (2001).
"B-cell development in progressively transformed germinal centers: similarities and differences compared with classical germinal centers and lymphocyte-predominant Hodgkin disease" . Blood . 97 (3): 714–9.
doi :
10.1182/blood.V97.3.714 .
PMID
11157489 .
Yamamoto K, Sugita N, Kobayashi T, et al. (2001).
"Evidence for a novel polymorphism affecting both N-linked glycosylation and ligand binding of the IgG receptor IIIB (CD16)" . Tissue Antigens . 57 (4): 363–6.
doi :
10.1034/j.1399-0039.2001.057004363.x .
PMID
11380948 .
Faast R, Thonglairoam V, Schulz TC, et al. (2001).
"Histone variant H2A.Z is required for early mammalian development" . Curr. Biol . 11 (15): 1183–7.
Bibcode :
2001CBio...11.1183F .
doi :
10.1016/S0960-9822(01)00329-3 .
PMID
11516949 .
Deng L, Wang D, de la Fuente C, et al. (2001).
"Enhancement of the p300 HAT activity by HIV-1 Tat on chromatin DNA" . Virology . 289 (2): 312–26.
doi :
10.1006/viro.2001.1129 .
PMID
11689053 .
Strausberg RL, Feingold EA, Grouse LH, et al. (2003).
"Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–903.
Bibcode :
2002PNAS...9916899M .
doi :
10.1073/pnas.242603899 .
PMC
139241 .
PMID
12477932 .
Rangasamy D, Berven L, Ridgway P, Tremethick DJ (2003).
"Pericentric heterochromatin becomes enriched with H2A.Z during early mammalian development" . EMBO J . 22 (7): 1599–607.
doi :
10.1093/emboj/cdg160 .
PMC
152904 .
PMID
12660166 .
Lusic M, Marcello A, Cereseto A, Giacca M (2004).
"Regulation of HIV-1 gene expression by histone acetylation and factor recruitment at the LTR promoter" . EMBO J . 22 (24): 6550–61.
doi :
10.1093/emboj/cdg631 .
PMC
291826 .
PMID
14657027 .
External links
PDBe-KB provides an overview of all the structure information available in the PDB for Human Histone H2A.Z