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Guayaquil Department was one of the departments of Gran Colombia created in 1824.

It bordered

• Ecuador Department in the East
• Azuay Department in the South
• Pacific Ocean in the West

Subdivisions

2 provincias y 9 cantones:

• Guayaquil Province. Capital: Guayaquil. Cantones: Guayaquil, Daule, Babahoyo, Baba, Punta de Santa Elena y Machala.
• Manabí Province. Capital: Portoviejo. Cantones: Portoviejo, Jipijapa, y Montecristi

2°12′S 79°58′W / 2.200°S 79.967°W / -2.200; -79.967