From Wikipedia, the free encyclopedia
A growth factor-like domain (GFLD) is a
protein domain structurally related to
epidermal growth factor, which has a high binding affinity for the
epidermal growth factor receptor. As structural domains within larger proteins, GFLD regions commonly bind
calcium
ions. A subtype present in the
N-terminal region of the
amyloid precursor protein is a member of the
heparin-binding class of GFLDs and may itself have
growth factor function, particularly in promoting
neuronal development.
References
- Rossjohn J, Cappai R, Feil SC, Henry A, McKinstry WJ, Galatis D, Hesse L, Multhaup G, Beyreuther K, Masters CL, Parker MW (April 1999). "Crystal structure of the N-terminal, growth factor-like domain of Alzheimer amyloid precursor protein". Nature Structural Biology. 6 (4): 327–31.
doi:
10.1038/7562.
PMID
10201399.
S2CID
30925432.