George Sisler (1893–1973) was an American Major League Baseball player and member of the National Baseball Hall of Fame.

George Sisler may also refer to:

• George F. Sisler (1896 or 1897–1992), American politician and businessman
• George Sisler Jr. (1917–2006), American minor league baseball general manager and president of the International League, son of the aforementioned George Sisler
• George K. Sisler (1937–1967), United States Army officer, recipient of the Medal of Honor for his actions in the Vietnam War

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