From Wikipedia, the free encyclopedia
Protein-coding gene in the species Homo sapiens
ADP-ribosylation factor-binding protein GGA3 is a
protein that in humans is encoded by the GGA3
gene .
[5]
[6]
This gene encodes a member of the Golgi-localized, gamma adaptin ear-containing, ARF-binding (GGA) family. This family includes ubiquitous coat proteins that regulate the trafficking of proteins between the trans-Golgi network and the lysosome. These proteins share an amino-terminal VHS domain which mediates sorting of the mannose 6-phosphate receptors at the trans-Golgi network. They also contain a carboxy-terminal region with homology to the ear domain of gamma-adaptins. Alternative splicing of this gene results in two transcript variants.
[7]
Interactions
GGA3 has been shown to
interact with
ARF1
[5]
[8] and
ARF3 .
[6]
[9]
References
^
a
b
c
GRCh38: Ensembl release 89: ENSG00000125447 –
Ensembl , May 2017
^
a
b
c
GRCm38: Ensembl release 89: ENSMUSG00000020740 –
Ensembl , May 2017
^
"Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^
"Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^
a
b Dell'Angelica EC, Puertollano R, Mullins C, Aguilar RC, Vargas JD, Hartnell LM, Bonifacino JS (April 2000).
"GGAs: a family of ADP ribosylation factor-binding proteins related to adaptors and associated with the Golgi complex" . The Journal of Cell Biology . 149 (1): 81–94.
doi :
10.1083/jcb.149.1.81 .
PMC
2175099 .
PMID
10747089 .
^
a
b Boman AL, Zhang C, Zhu X, Kahn RA (April 2000).
"A family of ADP-ribosylation factor effectors that can alter membrane transport through the trans-Golgi" . Molecular Biology of the Cell . 11 (4): 1241–55.
doi :
10.1091/mbc.11.4.1241 .
PMC
14844 .
PMID
10749927 .
^
"Entrez Gene: GGA3 golgi associated, gamma adaptin ear containing, ARF binding protein 3" .
^ Puertollano R, Randazzo PA, Presley JF, Hartnell LM, Bonifacino JS (April 2001).
"The GGAs promote ARF-dependent recruitment of clathrin to the TGN" . Cell . 105 (1): 93–102.
doi :
10.1016/S0092-8674(01)00299-9 .
PMID
11301005 .
S2CID
1158816 .
^ Boman AL, Salo PD, Hauglund MJ, Strand NL, Rensink SJ, Zhdankina O (September 2002).
"ADP-ribosylation factor (ARF) interaction is not sufficient for yeast GGA protein function or localization" . Molecular Biology of the Cell . 13 (9): 3078–95.
doi :
10.1091/mbc.E02-02-0078 .
PMC
124144 .
PMID
12221117 .
Further reading
Nagase T, Seki N, Tanaka A, Ishikawa K, Nomura N (August 1995).
"Prediction of the coding sequences of unidentified human genes. IV. The coding sequences of 40 new genes (KIAA0121-KIAA0160) deduced by analysis of cDNA clones from human cell line KG-1" . DNA Research . 2 (4): 167–74, 199–210.
doi :
10.1093/dnares/2.4.167 .
PMID
8590280 .
Hirst J, Lui WW, Bright NA, Totty N, Seaman MN, Robinson MS (April 2000).
"A family of proteins with gamma-adaptin and VHS domains that facilitate trafficking between the trans-Golgi network and the vacuole/lysosome" . The Journal of Cell Biology . 149 (1): 67–80.
doi :
10.1083/jcb.149.1.67 .
PMC
2175106 .
PMID
10747088 .
Takatsu H, Yoshino K, Nakayama K (May 2000). "Adaptor gamma ear homology domain conserved in gamma-adaptin and GGA proteins that interact with gamma-synergin". Biochemical and Biophysical Research Communications . 271 (3): 719–25.
doi :
10.1006/bbrc.2000.2700 .
PMID
10814529 .
Puertollano R, Randazzo PA, Presley JF, Hartnell LM, Bonifacino JS (April 2001).
"The GGAs promote ARF-dependent recruitment of clathrin to the TGN" . Cell . 105 (1): 93–102.
doi :
10.1016/S0092-8674(01)00299-9 .
PMID
11301005 .
S2CID
1158816 .
Puertollano R, Aguilar RC, Gorshkova I, Crouch RJ, Bonifacino JS (June 2001). "Sorting of mannose 6-phosphate receptors mediated by the GGAs". Science . 292 (5522): 1712–6.
Bibcode :
2001Sci...292.1712P .
doi :
10.1126/science.1060750 .
PMID
11387475 .
S2CID
30836125 .
Misra S, Puertollano R, Kato Y, Bonifacino JS, Hurley JH (February 2002). "Structural basis for acidic-cluster-dileucine sorting-signal recognition by VHS domains". Nature . 415 (6874): 933–7.
Bibcode :
2002Natur.415..933M .
doi :
10.1038/415933a .
PMID
11859375 .
S2CID
4430757 .
Takatsu H, Yoshino K, Toda K, Nakayama K (July 2002).
"GGA proteins associate with Golgi membranes through interaction between their GGAH domains and ADP-ribosylation factors" . The Biochemical Journal . 365 (Pt 2): 369–78.
doi :
10.1042/BJ20020428 .
PMC
1222692 .
PMID
11950392 .
Kato Y, Misra S, Puertollano R, Hurley JH, Bonifacino JS (July 2002). "Phosphoregulation of sorting signal-VHS domain interactions by a direct electrostatic mechanism". Nature Structural Biology . 9 (7): 532–6.
doi :
10.1038/nsb807 .
PMID
12032548 .
S2CID
23740463 .
Doray B, Bruns K, Ghosh P, Kornfeld SA (June 2002).
"Autoinhibition of the ligand-binding site of GGA1/3 VHS domains by an internal acidic cluster-dileucine motif" . Proceedings of the National Academy of Sciences of the United States of America . 99 (12): 8072–7.
Bibcode :
2002PNAS...99.8072D .
doi :
10.1073/pnas.082235699 .
PMC
123022 .
PMID
12060753 .
Wasiak S, Legendre-Guillemin V, Puertollano R, Blondeau F, Girard M, de Heuvel E, Boismenu D, Bell AW, Bonifacino JS, McPherson PS (September 2002).
"Enthoprotin: a novel clathrin-associated protein identified through subcellular proteomics" . The Journal of Cell Biology . 158 (5): 855–62.
doi :
10.1083/jcb.200205078 .
PMC
2173151 .
PMID
12213833 .
Doray B, Ghosh P, Griffith J, Geuze HJ, Kornfeld S (September 2002). "Cooperation of GGAs and AP-1 in packaging MPRs at the trans-Golgi network". Science . 297 (5587): 1700–3.
Bibcode :
2002Sci...297.1700D .
doi :
10.1126/science.1075327 .
PMID
12215646 .
S2CID
8810528 .
Boman AL, Salo PD, Hauglund MJ, Strand NL, Rensink SJ, Zhdankina O (September 2002).
"ADP-ribosylation factor (ARF) interaction is not sufficient for yeast GGA protein function or localization" . Molecular Biology of the Cell . 13 (9): 3078–95.
doi :
10.1091/mbc.E02-02-0078 .
PMC
124144 .
PMID
12221117 .
Mattera R, Arighi CN, Lodge R, Zerial M, Bonifacino JS (January 2003).
"Divalent interaction of the GGAs with the Rabaptin-5-Rabex-5 complex" . The EMBO Journal . 22 (1): 78–88.
doi :
10.1093/emboj/cdg015 .
PMC
140067 .
PMID
12505986 .
Wakasugi M, Waguri S, Kametaka S, Tomiyama Y, Kanamori S, Shiba Y, Nakayama K, Uchiyama Y (July 2003). "Predominant expression of the short form of GGA3 in human cell lines and tissues". Biochemical and Biophysical Research Communications . 306 (3): 687–92.
doi :
10.1016/S0006-291X(03)01032-5 .
PMID
12810073 .
He X, Zhu G, Koelsch G, Rodgers KK, Zhang XC, Tang J (October 2003). "Biochemical and structural characterization of the interaction of memapsin 2 (beta-secretase) cytosolic domain with the VHS domain of GGA proteins". Biochemistry . 42 (42): 12174–80.
doi :
10.1021/bi035199h .
PMID
14567678 .
Ghosh P, Griffith J, Geuze HJ, Kornfeld S (November 2003).
"Mammalian GGAs act together to sort mannose 6-phosphate receptors" . The Journal of Cell Biology . 163 (4): 755–66.
doi :
10.1083/jcb.200308038 .
PMC
2173681 .
PMID
14638859 .
Shiba Y, Katoh Y, Shiba T, Yoshino K, Takatsu H, Kobayashi H, Shin HW, Wakatsuki S, Nakayama K (February 2004).
"GAT (GGA and Tom1) domain responsible for ubiquitin binding and ubiquitination" . The Journal of Biological Chemistry . 279 (8): 7105–11.
doi :
10.1074/jbc.M311702200 .
PMID
14660606 .
PDB gallery
1jpl : GGA3 VHS domain complexed with C-terminal peptide from cation-independent mannose 6-phosphate receptor
1juq : GGA3 VHS domain complexed with C-terminal peptide from cation-dependent Mannose 6-phosphate receptor
1lf8 : Complex of GGA3-VHS Domain and CI-MPR C-terminal Phosphopeptide
1p4u : CRYSTAL STRUCTURE OF GGA3 GAE DOMAIN IN COMPLEX WITH RABAPTIN-5 PEPTIDE
1wr6 : Crystal structure of GGA3 GAT domain in complex with ubiquitin
1yd8 : COMPLEX OF HUMAN GGA3 GAT DOMAIN AND UBIQUITIN