He married firstly in 1781 Maria Isabella Giustiniani dei Principi di
Bassano (
Rome, November 8, 1763 – 1783), without issue.
He married secondly on April 19, 1784 HSH Countess Maria Leopoldina von
Khevenhüller-Metsch (August 22, 1764 – February 24, 1845), by whom he had seven children:
Don Sigismondo dei Principi Ruspoli (1787 – May 11, 1849), married firstly Faustina, Contessa Tomassini (? – 1832), by whom he had a son, and secondly Paola Bellinzoni (
Rome, August 28, 1819 –
Rome, March 29, 1892), by whom he had a son:
Don Enrico dei Principi Ruspoli (1832 – November 20, 1869), married Emilia de Pasqualis (
Athens, September 7, 1834 – ca 1895), and had five children:
Don Romolo dei Principi Ruspoli (
Rome, July 19, 1850 – September 10, 1912), married in
Paris, November 23, 1881, Julie Peynaud (October 20, 1838 – August, 1884), without issue.
Don Orazio dei Principi Ruspoli (
Rome, December 24, 1852 – ?), unmarried and without issue.
Don Sigismondo dei Principi Ruspoli (
Rome, June 5, 1854 – 1911), married at
Livorno, September 30, 1872, Zelinda Lavagna, without issue.
Donna Virginia dei Principi Ruspoli (
Rome, May 5, 1855 – 1911), married on April 15, 1878, Giovanni Scaletta.
Donna Beatrice dei Principi Ruspoli (
Rome, April 29, 1864 – 1911), married on January 8, 1888, in Rome, Filippo Marchese Buccico della Conca,[1] with issue.
Don Leopoldo dei Principi Ruspoli (
Rome, June 5, 1847 –
Genazzano, January 2, 1932), Lieutenant of the
Noble Guard. Unmarried and without issue.
Donna Amalia dei Principi Ruspoli (July 30, 1790 – 1867), married Vincenzo, Conte Pianciani.
Don Leopoldo dei Principi Ruspoli (1791 – September 27, 1817), unmarried and without issue.
Don Emanuele dei Principi Ruspoli (1794–1837), cadetto of the
Noble Guard. It was sent on an expedition to Vienna on 9/23/1816 for the Archbishop of Olmutz (Moravia) and Bishop of Gurk (Carinthia), and to Madrid on 10/1/1826 for the Apostolic
Nuncio Monsignor Giustiniani. Married Adélaïde Giraud (? – 1835), without issue.