François Guillemot FMedSci FRS
Alma mater	Ecole Normale Supérieure, Paris
Known for	Behaviour of neural stem cells
Scientific career
Fields	Molecular neurobiology
Institutions	Harvard Medical School Mount Sinai Hospital, Toronto National Institute for Medical Research Francis Crick Institute
Website	Official website

François Guillemot, FMedSci, FRS is a French neurobiologist, currently working at the Francis Crick Institute in London. His research focuses on the behaviour of neural stem cells in embryos and adult brains. ^[1]

Life and career

After studying at the École Normale Supérieure in Paris, France, Guillemot took his Ph.D. in immunology at the Institut d’Embryologie du CNRS. This was followed by postdoctoral research at Harvard Medical School and Mount Sinai Hospital, Toronto. Between 1994 and 2002, Guillemot set up and ran a laboratory at the Institut de Génétique et de Biologie Moléculaire et Cellulaire in Strasbourg. He then relocated to the National Institute for Medical Research in London in 2002, where he was head of the Division of Molecular Neurobiology, before moving to the Francis Crick Institute the following decade. He has been President of the International Society for Developmental Neurobiology since 2009. ^{[1] [2]}

Research

Guillemot's research investigates stem cells at the molecular level and how they become different types of cells in the brain. His research has focused on proneural genes, including ASCL1 (MASH1) ^[3] and neurogenins 1,2 and 3. ^[4] His two current strands of research are to understand the gene regulatory networks that control neural stem cells and the function of individual genes within these cells. By learning how neural cells form and develop, Guillemot hopes to develop new therapies for brain disorders. ^[5]

Awards

Guillemot was awarded the Ribeiro Caro Almela Prize for Research in Developmental Neurobiology in 2007. He was elected to the European Molecular Biology Organization (EMBO) in 2000, became a Fellow of the Academy of Medical Sciences (FMedSci) in 2009, and a Fellow of the Royal Society (FRS) in 2020. ^{[1] [4]}

Selected publications

• Bertrand, Nicolas; Castro, Diogo S.; Guillemot, François (July 2002). "Proneural genes and the specification of neural cell types". Nature Reviews Neuroscience. 3 (7): 517–530. doi: 10.1038/nrn874. eISSN  1471-0048. ISSN  1471-003X. PMID  12094208. S2CID  205512016. Retrieved 18 August 2022.
• Gradwohl, Gérard; Dierich, Andrée; LeMeur, Marianne; Guillemot, François (15 February 2000). "neurogenin3 is required for the development of the four endocrine cell lineages of the pancreas". Proceedings of the National Academy of Sciences. 97 (4): 1607–1611. Bibcode: 2000PNAS...97.1607G. doi: 10.1073/pnas.97.4.1607. eISSN  1091-6490. ISSN  0027-8424. PMC  26482. PMID  10677506.
• Jensen, Jan; Pedersen, Erna Engholm; Galante, Philip; Hald, Jacob; Heller, R. Scott; et al. (January 2000). "Control of endodermal endocrine development by Hes-1". Nature Genetics. 24 (1): 36–44. doi: 10.1038/71657. eISSN  1546-1718. ISSN  1061-4036. PMID  10615124. S2CID  52872659. Retrieved 18 August 2022.
• Guillemot, François; Lo, Li-Ching; Johnson, Jane E.; Auerbach, Anna; Anderson, David J.; et al. (November 1993). "Mammalian achaete-scute homolog 1 is required for the early development of olfactory and autonomic neurons". Cell. 75 (3): 463–476. doi: 10.1016/0092-8674(93)90381-Y. ISSN  0092-8674. PMID  8221886. S2CID  19459236. Retrieved 18 August 2022.

References

External links

• Official website