English: Paths of activation and deactivation for
levodopa, focusing on the mechanisms of various anti-Parkinson drugs. COMT = catecholamine-O-methyltransferase, AADC = aromatic L-amino acid decarboxylase, CNS = central nervous system, MAO-B = monoamine oxidase B, DOPAC = 3,4-dihydroxyphenylacetic acid. 3-methoxytyrosine and DOPAC are inactive, dopamine in the periphery causes side effects but no antiparkinson effects, and dopamine in the CNS is responsible for the desired antiparkinson effects. Reference:Mutschler, E; M Schäfer-Korting (2001) (in German) Arzneimittelwirkungen (8th ed.),
Stuttgart: Wissenschaftliche Verlagsgesellschaft, pp. 313–316 ISBN:
3-8047-1763-2.
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