DescriptionArchitecture of an OI system for wetware computing.jpg
English: "Architecture of an OI system for biological computing. At the core of OI is the 3D brain cell culture (organoid) that performs the computation. The learning potential of the organoid is optimized by culture conditions and enrichment by cells and genes critical for learning (including IEGs). The scalability, viability, and durability of the organoid are supported by integrated microfluidic systems. Various types of input can be provided to the organoid, including electrical and chemical signals, synthetic signals from machine sensors, and natural signals from connected sensory organoids (e.g. retinal). We anticipate high-resolution output measurement both by electrophysiological recordings obtained via specially designed 2D or 3D (shell) MEA, and potentially from implantable probes, and imaging of organoid structural and functional properties. These outputs can be used directly for computation purposes and as biofeedback to promote organoid learning. AI and machine learning are used throughout to encode and decode signals and to develop hybrid biocomputing solutions, in conjunction with a suitable big-data management system."
Authors of the study:
Lena Smirnova
Brian S. Caffo
David H. Gracias
Qi Huang
Itzy E. Morales Pantoja
Bohao Tang
Donald J. Zack
Cynthia A. Berlinicke
J. Lomax Boyd
Timothy D. Harris
Erik C. Johnson
Brett J. Kagan
Jeffrey Kahn
Alysson R. Muotri
Barton L. Paulhamus
Jens C. Schwamborn
Jesse Plotkin
Alexander S. Szalay
Joshua T. Vogelstein
Paul F. Worley
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From the study "Organoid intelligence (OI): the new frontier in biocomputing and intelligence-in-a-dish"
Uploaded a work by Authors of the study: Lena Smirnova Brian S. Caffo David H. Gracias Qi Huang Itzy E. Morales Pantoja Bohao Tang Donald J. Zack Cynthia A. Berlinicke J. Lomax Boyd Timothy D. Harris Erik C. Johnson Brett J. Kagan Jeffrey Kahn Alysson R. Muotri Barton L. Paulhamus Jens C. Schwamborn Jesse Plotkin Alexander S. Szalay Joshua T. Vogelstein Paul F. Worley Thomas Hartung from https://www.frontiersin.org/journals/science/articles/10.3389/fsci.2023.1017235 with UploadWizard
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