Fc receptor-like molecules (FCRLs) are a class of proteins that resemble Fc receptors. They have been characterized in a number of species, including humans and mice. They are preferentially expressed by B lymphocytes. Unlike the classical Fc receptors, there is no strong evidence that suggests that FCRLs bind to the Fc portion of antibodies. Their function is unknown. [1]
It has been indicated that FCRLs may be a unique marker for immune cells in the brain called microglia, compared to other CNS cells and peripheral immune cells. [2]
Members
See also
References
- ^ Davis RS (2007). "Fc receptor-like molecules". Annual Review of Immunology. 25: 525–60. doi: 10.1146/annurev.immunol.25.022106.141541. PMID 17201682.
- ^ Butovsky O, Jedrychowski MP, Moore CS, Cialic R, Lanser AJ, Gabriely G, Koeglsperger T, Dake B, Wu PM, Doykan CE, Fanek Z, Liu L, Chen Z, Rothstein JD, Ransohoff RM, Gygi SP, Antel JP, Weiner HL (January 2014). "Identification of a unique TGF-β-dependent molecular and functional signature in microglia" (PDF). Nature Neuroscience. 17 (1): 131–43. doi: 10.1038/nn.3599. PMC 4066672. PMID 24316888.
- ^ Santiago T, Kulemzin SV, Reshetnikova ES, Chikaev NA, Volkova OY, Mechetina LV, Zhao M, Davis RS, Taranin AV, Najakshin AM, Hendershot LM, Burrows PD (January 2011). "FCRLA is a resident endoplasmic reticulum protein that associates with intracellular Igs, IgM, IgG and IgA". International Immunology. 23 (1): 43–53. doi: 10.1093/intimm/dxq456. PMC 3003704. PMID 21149418.
Further reading
- Maltais LJ, Lovering RC, Taranin AV, Colonna M, Ravetch JV, Dalla-Favera R, Burrows PD, Cooper MD, Davis RS (May 2006). "New nomenclature for Fc receptor-like molecules". Nature Immunology. 7 (5): 431–2. doi: 10.1038/ni0506-431. PMID 16622424.
- Ehrhardt GR, Cooper MD (2011). "Immunoregulatory Roles for Fc Receptor-Like Molecules". In Ahmed R, Honjo T (eds.). Negative Co-Receptors and Ligands. Current Topics in Microbiology and Immunology. pp. 89–104. doi: 10.1007/82_2010_88. ISBN 978-3-642-19544-0. PMID 20680805.
- Aranha C, Bordekar A, Shahani S (November 1998). "Isolation and purification of an early pregnancy factor-like molecule from culture supernatants obtained from lymphocytes of pregnant women: II. Identification of the molecule as a Fc-receptor-like molecule: a preliminary report". Journal of Assisted Reproduction and Genetics. 15 (10): 619–24. doi: 10.1023/A:1020389512677. PMC 3454852. PMID 9866072.
- Wu H, Yang LH, Zuo J, Liang YL, Li PQ, Liu W, Xie XD (December 2010). "Fc receptor-like 3 gene polymorphisms confer susceptibility to rheumatoid arthritis in a Chinese population". Human Immunology. 71 (12): 1203–8. doi: 10.1016/j.humimm.2010.08.002. PMID 20732364.
- Ehrhardt GR, Leu CM, Zhang S, Aksu G, Jackson T, Haga C, Hsu JT, Schreeder DM, Davis RS, Cooper MD (2007). "Fc Receptor–like Proteins (FCRL): Immunomodulators of B Cell Function". In Gupta S, Alt F, Cooper M, Melchers F, Rajewsky K (eds.). Mechanisms of Lymphocyte Activation and Immune Regulation XI. Advances in Experimental Medicine and Biology. pp. 155–62. doi: 10.1007/0-387-46530-8_14. ISBN 978-0-387-46527-2. PMID 17338184.
- Rozsnyay Z, Sármay G, Szabó I, Medgyesi G, Gorini G, Gergely J (September 1990). "Fine specificity of a rabbit antibody interacting with human IgG Fc receptor-like molecules". Immunology Letters. 25 (4): 303–11. doi: 10.1016/0165-2478(90)90200-a. PMID 2147423.
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