Far upstream element-binding protein 1 is a
protein that in humans is encoded by the FUBP1gene.[5][6]
This gene encodes a ssDNA binding protein that activates the far upstream element (FUSE) of c-myc and stimulates expression of c-myc in undifferentiated cells. Regulation of FUSE by FUBP occurs through single-strand binding of FUBP to the non-coding strand. This protein has been shown to function as an ATP-dependent DNA helicase.[6]
^Kim, Min Jung; Park Bum-Joon; Kang Young-Sun; Kim Hyoung June; Park Jae-Hyun; Kang Jung Woo; Lee Sang Won; Han Jung Min; Lee Han-Woong; Kim Sunghoon (July 2003). "Downregulation of FUSE-binding protein and c-myc by tRNA synthetase cofactor p38 is required for lung cell differentiation". Nat. Genet. 34 (3). United States: 330–6.
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ISSN1061-4036.
PMID12819782.
S2CID41006480.
^Williams, B Y; Hamilton S L; Sarkar H K (March 2000). "The survival motor neuron protein interacts with the transactivator FUSE binding protein from human fetal brain". FEBS Lett. 470 (2). NETHERLANDS: 207–10.
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ISSN0014-5793.
PMID10734235.
S2CID28330997.
Williams BY, Hamilton SL, Sarkar HK (2000). "The survival motor neuron protein interacts with the transactivator FUSE binding protein from human fetal brain". FEBS Lett. 470 (2): 207–10.
doi:
10.1016/S0014-5793(00)01320-X.
PMID10734235.
S2CID28330997.
Kim MJ, Park BJ, Kang YS, et al. (2003). "Downregulation of FUSE-binding protein and c-myc by tRNA synthetase cofactor p38 is required for lung cell differentiation". Nat. Genet. 34 (3): 330–6.
doi:
10.1038/ng1182.
PMID12819782.
S2CID41006480.
Brandenberger R, Wei H, Zhang S, et al. (2005). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation". Nat. Biotechnol. 22 (6): 707–16.
doi:
10.1038/nbt971.
PMID15146197.
S2CID27764390.
Rush J, Moritz A, Lee KA, et al. (2005). "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells". Nat. Biotechnol. 23 (1): 94–101.
doi:
10.1038/nbt1046.
PMID15592455.
S2CID7200157.
Fautsch MP, Vrabel AM, Johnson DH (2006). "The identification of myocilin-associated proteins in the human trabecular meshwork". Exp. Eye Res. 82 (6): 1046–52.
doi:
10.1016/j.exer.2005.09.016.
PMID16289162.