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FERb 033
Identifiers
  • 2-Chloro-3′-fluoro-3,4′-dihydroxy-[1,1-biphenyl]-4-carboxaldehyde oxime
CAS Number
ChemSpider
UNII
Chemical and physical data
FormulaC13H9ClFNO3
Molar mass281.67 g·mol−1
3D model ( JSmol)
  • c1cc(c(cc1c2ccc(c(c2Cl)O)/C=N/O)F)O
  • InChI=1S/C13H9ClFNO3/c14-12-9(3-1-8(6-16-19)13(12)18)7-2-4-11(17)10(15)5-7/h1-6,17-19H/b16-6+
  • Key:LRRMQNGSYOUANY-OMCISZLKSA-N

FERb 033 is a synthetic, nonsteroidal estrogen that was synthesized in 2009 and is used in scientific research. [1] [2] It is a potent and selective ERβ agonist (Ki = 7.1 nM, EC50 = 4.8 nM), with 62-fold selectivity for the ERβ over the ERα. [1] [2]

See also

References

  1. ^ a b Minutolo F, Bertini S, Granchi C, Marchitiello T, Prota G, Rapposelli S, Tuccinardi T, Martinelli A, Gunther JR, Carlson KE, Katzenellenbogen JA, Macchia M (2009). "Structural evolutions of salicylaldoximes as selective agonists for estrogen receptor beta". J. Med. Chem. 52 (3): 858–67. doi: 10.1021/jm801458t. PMID  19128016.
  2. ^ a b Reese JM, Suman VJ, Subramaniam M, Wu X, Negron V, Gingery A, Pitel KS, Shah SS, Cunliffe HE, McCullough AE, Pockaj BA, Couch FJ, Olson JE, Reynolds C, Lingle WL, Spelsberg TC, Goetz MP, Ingle JN, Hawse JR (2014). "ERβ1: characterization, prognosis, and evaluation of treatment strategies in ERα-positive and -negative breast cancer". BMC Cancer. 14: 749. doi: 10.1186/1471-2407-14-749. PMC  4196114. PMID  25288324.



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