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American virologist
Eva H. Gottwein
Education Postdoctoral: Duke University 2010
PhD, Biology: Heidelberg University 2005 Scientific career Fields Virology, Microbiology, Immunology Institutions Northwestern University Feinberg School of Medicine
Eva Henriette Gottwein is a virologist and Associate Professor of
Microbiology -
Immunology at
Northwestern University Feinberg School of Medicine in Chicago, Illinois. The main focus of her research is the role of
viral
miRNAs involved in
herpesviral
oncogenesis .
[1] Gottwein is member of
Robert H. Lurie Comprehensive Cancer Center of
Northwestern University . Her contributions as a member include the focus on how encoded
miRNAs target and function in the human oncogenic herpesvirus
Kaposi's sarcoma-associated herpesvirus known as KSHV.
[2]
Education and career
Gottwein received her PhD in biology from
Heidelberg University in 2005.
[1]
During her postdoctoral work, Eva Gottwein studied herpesviral
miRNA in Bryan Cullen's laboratory at
Duke University .
[3] Eva Gottwein currently is an associate professor of
microbiology -
immunology at Northwestern University Feinberg School of Medicine.
[1]
Research contributions
The focus of her work involves identifying the function of
microRNAs that are encoded in the human herpesvirus
Kaposi's sarcoma-associated herpesvirus (KSHV). KSHV causes tumors by infecting
endothelial cells. Since the
AIDS epidemic in Africa, KSHV is also known to attack and infect
B lymphocytes , which results in a person having
B cell
lymphomas and
effusion lymphoma.
[4] Prior to her laboratory experience at Duke University, the target for KSHV
microRNAs were unknown.
[3] Gottwein recently studied the expression of KSHV mRNAs. Through her research she found that
Kaposi's sarcoma-associated herpesvirus (KSHV) has nearly 20 viral
mRNAs . During her research she discovered that miR-K10 by itself has the ability to transform cells.
[5] In another experiment, Gottwein research found that the function of
miRNA KSHV proteins that were used to target certain cellular
RNAs . Through her experiment she discovered abnormal ligand reactions that occurred during the absence of exogenous ligase and a unique
miRNA binding site.
[6] Her goal for the next few years is to learn more about the targetome of the KSHV
microRNAs and identification of the virus' functions in oncogenesis.
[3]
Kaposis Sarcoma Lesions
Micrograph of Kaposi sarcoma.
H&E stain .
Notable publications
Forte, Eleonora; Raja, Archana N.; Shamulailatpam, Priscilla; Manzano, Mark; Schipma, Matthew J.; Casey, John L.; Gottwein, Eva (2015-02-15).
"MicroRNA-mediated transformation by the Kaposi's sacromaassociated herpesvirus Kaposin locus" . Journal of Virology . 89 (4): 2333–2341.
doi :
10.1128/jvi.03317-14 .
PMC
4338870 .
PMID
25505059 .
Khare, Sonal; Ratsimandresy, Rojo A.; De Almeida, Lucia; Cuda, Carla M.; Rellick, Stephanie L.; Misharin, Alexander V.; Wallin, Melissa C.; Gangopadhyay, Anu; Forte, Eleonora; Gottwein, Eva (April 2014).
"The PYRIN domain-only protein POP3 inhibits ALR inflammasomes and regulates responses to infection with DNA viruses" . Nature Immunology . 15 (4): 343–353.
doi :
10.1038/ni.2829 .
PMC
4123781 .
PMID
24531343 .
Gottwein, Eva (2012).
"Kaposi's sarcoma-associated herpesvirus microRNAs" . Frontiers in Microbiology . 3 : 165.
doi :
10.3389/fmicb.2012.00165 .
PMC
3342587 .
PMID
22563327 .
Gottwein, Eva; Corcoran, David L.; Mukherjee, Neelanjan; Skalsky, Rebecca L.; Hafner, Markus; Nusbam, Jeffrey D.; Shamulailatpam, Priscilla; Love, Cassandra L.; Dave, Sandeep S.; Tuschl, Thomas (2011-11-17).
"viral microrna targetome of kshv-infected primary effusion lymphoma cell lines" . Cell Host and Microbe . 10 (5): 515–526.
doi :
10.1016/j.chom.2011.09.012 .
PMC
3222872 .
PMID
22100165 .
Gottwein, Eva; Cullen, Bryan R. (2010-05-15).
"A human herpesvirus MicroRNA inhibits p21 expression and attenuates p21-mediated cell cycle arrest" . Journal of Virology . 84 (10): 5229–5237.
doi :
10.1128/jvi.00202-10 .
PMC
2863803 .
PMID
20219912 .
Gottwein, Eva; Cullen, Bryan R. (2008-06-12).
"Viral and Cellular MicroRNAs as Determinants of Viral Pathogenesis and Immunity" . Cell Host and Microbe . 3 (6): 375–387.
doi :
10.1016/j.chom.2008.05.002 .
PMC
3079432 .
PMID
18541214 .
Gottwein, Eva; Mukherjee, Neelanjan; Sachse, Christoph; Frenzel, Corina; Majoros, William H.; Jen-; Chi, Tsan A.; Braich, Ravi; Manoharan, Muthiah; Soutschek, Jurgen; Ohler, Uwe (December 2007).
"A viral microRNA functions as an orthologue of cellular miR-155" . Nature . 450 (7172): 1096–1099.
Bibcode :
2007Natur.450.1096G .
doi :
10.1038/nature05992 .
PMC
2614920 .
PMID
18075594 .
Gottwein, Eva; Cai, Xuezhong; Cullen, Bryan R. (June 2006).
"A novel assay for viral microRNA function identifies a single nucleotide polymorphism that affects Drosha processing" . Journal of Virology . 80 (11): 5321–5326.
doi :
10.1128/jvi.02734-05 .
PMC
1472151 .
PMID
16699012 .
Gottwein, Eva; Jager, Stefanie; Habermann, Anja; Krausslich, Hans-Georg (July 2006).
"Cumulative mutations of ubiquitin acceptor sites in human immunodeficiency virus type 1 Gag cause a late budding defect" . Journal of Virology . 80 (13): 6267–6275.
doi :
10.1128/jvi.02177-05 .
PMC
1488962 .
PMID
16775314 .
Gottwein, Eva; Krausslich, Hans-Georg (July 2005).
"Analysis of human immunodeficiency virus type 1 Gag ubiquitination" . Journal of Virology . 79 (14): 9134–9144.
doi :
10.1128/jvi.79.14.9134-9144.2005 .
PMC
1168789 .
PMID
15994808 .
Gottwein, Eva; Bodem, Jochen; Muller, Barbara; Schmechel, Ariane; Zentgraf, Hanswalter; Krausslich, Hans-Georg (September 2003).
"The Mason-Pfizer monkey virus PPPY and PSAP motifs both contribute to virus release" . Journal of Virology . 77 (17): 9474–9485.
doi :
10.1128/jvi.77.17.9474-9485.2003 .
PMC
187385 .
PMID
12915562 .
References
^
a
b
c
"Faculty Profiles" . Northwestern University Feinberg School of Medicine . Northwestern University.
^
"Research and Education" . Robert H. Lurie Comprehensive Cancer Center of Northwestern University .
^
a
b
c
"Faculty Profile: Eva Gottwein, PhD, Assistant Professor of Microbiology-Immunology" . Northwestern Medicine . Archived from
the original on 2015-05-18. Retrieved 2015-05-11 .
^
"Gottwein Lab Northwestern University Department of Microbiology-Immunology" . Gottwein Lab . Archived from
the original on 2015-02-01. Retrieved 2015-05-10 .
^ Forte, E; Raja, A; Shamulaitlatpam, P; Manzano, M; Schipma, MJ; Casey, JL; Gottwein, E (2015).
"MicroRNA- mediated transformation by the Kaposi's sacromaassociated herpesvirus Kaposin locus" . Journal of Virology . 89 (4): 2333–2341.
doi :
10.1128/JVI.03317-14 .
PMC
4338870 .
PMID
25505059 .
^ Grosswendt, S; Filipchyk, A; Manzano, M; Kilronomos, F; Schilling, M; Herzog, M; Gottwein, E; Rajewsky, N (2015).
"Unambiguous Identification of miRNA: Target site interactions by different types of ligation reactions" . Molecular Cell . 54 (6): 1042–1054.
doi :
10.1016/j.molcel.2014.03.049 .
PMC
4181535 .
PMID
24857550 .