Eosinophilic folliculitis is an
itchyrash with an unknown cause that is most common among individuals with
HIV, though it can occur in HIV-negative individuals where it is known by the
eponymOfuji disease.[2] EF consists of itchy red bumps (
papules) centered on
hair follicles and typically found on the upper body, sparing the abdomen and legs. The name eosinophilic folliculitis refers to the predominant
immune cells associated with the disease (
eosinophils) and the involvement of the hair follicles.
Eosinophilic folliculitis may be suspected clinically when an individual with HIV exhibits the classic symptoms. The diagnosis can be supported by the finding of
eosinophilia but a
skin biopsy is necessary to establish it. Skin biopsies reveal
lymphocytic and eosinophilic
inflammation around the hair follicles.
Eosinophilic folliculitis associated with HIV infection typically affects individuals with advanced HIV and low
T helper cell counts.[8] It affects both men and women as well as children with HIV and is found throughout the world.
EF may also affect individuals with hematologic disease such as
leukemia and
lymphoma.[9] It may also affect otherwise normal infants in a self-limited form.[10] HIV-negative individuals can also develop EF — this is more common in Japan.[11]
^Parker, SR; Parker, DC; McCall, CO (2006). "Eosinophilic folliculitis in HIV-infected women: case series and review". American Journal of Clinical Dermatology. 7 (3): 193–200.
doi:
10.2165/00128071-200607030-00006.
PMID16734507.
S2CID71615655.
^Patrizi, A; Chieregato, C; Visani, G; Morrone, P; Patrone, P (2004). "Leukaemia-associated eosinophilic folliculitis (Ofuji's disease)". Journal of the European Academy of Dermatology and Venereology. 18 (5): 596–8.
doi:
10.1111/j.1468-3083.2004.00982.x.
PMID15324404.
S2CID45311563.