Enhancer_of_polycomb_homolog_2_(drosophila) References

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EPC2

Identifiers

EPC2, EPC-LIKE, enhancer of polycomb homolog 2

External IDs

OMIM: 611000; MGI: 1278321; HomoloGene: 32274; GeneCards: EPC2; OMA: EPC2 - orthologs

Gene location ( Human)

Chr.	Chromosome 2 (human)^[1]

Band	2q23.1	Start	148,644,440 bp^[1]
Band	2q23.1	End	148,787,569 bp^[1]

Gene location ( Mouse)

Chr.	Chromosome 2 (mouse)^[2]

Band	2 C1.1\|2 28.62 cM	Start	49,341,498 bp^[2]
Band	2 C1.1\|2 28.62 cM	End	49,441,960 bp^[2]

RNA expression pattern

Human

Mouse (ortholog)

Top expressed in

germinal epithelium

Achilles tendon

ganglionic eminence

ventricular zone

endothelial cell

sural nerve

bone marrow cells

corpus callosum

amniotic fluid

monocyte

Top expressed in

hand

substantia nigra

ureter

zygote

lobe of cerebellum

cerebellar vermis

medullary collecting duct

fossa

lateral septal nucleus

ventromedial nucleus

More reference expression data

n/a

Gene ontology
Molecular function	histone acetyltransferase activity
Cellular component	nucleus NuA4 histone acetyltransferase complex Piccolo NuA4 histone acetyltransferase complex
Biological process	regulation of transcription, DNA-templated transcription, DNA-templated cellular response to DNA damage stimulus DNA repair regulation of transcription by RNA polymerase II histone acetylation chromatin organization
Sources: Amigo / QuickGO

Species

Human

Mouse


26122


227867


ENSG00000135999


ENSMUSG00000069495


Q52LR7


Q8C0I4

RefSeq (mRNA)


NM_015630


NM_172663

RefSeq (protein)


NP_056445


NP_766251

Location (UCSC)

Chr 2: 148.64 – 148.79 Mb

Chr 2: 49.34 – 49.44 Mb

PubMed search

^[3]

^[4]

View/Edit Human

View/Edit Mouse

Enhancer of polycomb homolog 2 (Drosophila) is a protein that in humans is encoded by the EPC2 gene.^[5]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000135999 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000069495 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: Enhancer of polycomb homolog 2 (Drosophila)".

Further reading

Doyon Y, Cayrou C, Ullah M, Landry AJ, Côté V, Selleck W, Lane WS, Tan S, Yang XJ, Côté J (January 2006). "ING tumor suppressor proteins are critical regulators of chromatin acetylation required for genome expression and perpetuation". Molecular Cell. 21 (1): 51–64. doi: 10.1016/j.molcel.2005.12.007. PMID 16387653.
Kim J, Woo AJ, Chu J, Snow JW, Fujiwara Y, Kim CG, Cantor AB, Orkin SH (October 2010). "A Myc network accounts for similarities between embryonic stem and cancer cell transcription programs". Cell. 143 (2): 313–24. doi: 10.1016/j.cell.2010.09.010. PMC 3018841. PMID 20946988.
Kim S, Swaminathan S, Shen L, Risacher SL, Nho K, Foroud T, Shaw LM, Trojanowski JQ, Potkin SG, Huentelman MJ, Craig DW, DeChairo BM, Aisen PS, Petersen RC, Weiner MW, Saykin AJ (January 2011). "Genome-wide association study of CSF biomarkers Abeta1-42, t-tau, and p-tau181p in the ADNI cohort". Neurology. 76 (1): 69–79. doi: 10.1212/WNL.0b013e318204a397. PMC 3030225. PMID 21123754.
Doyon Y, Selleck W, Lane WS, Tan S, Côté J (March 2004). "Structural and functional conservation of the NuA4 histone acetyltransferase complex from yeast to humans". Molecular and Cellular Biology. 24 (5): 1884–96. doi: 10.1128/MCB.24.5.1884-1896.2004. PMC 350560. PMID 14966270.
Hayakawa T, Zhang F, Hayakawa N, Ohtani Y, Shinmyozu K, Nakayama J, Andreassen PR (April 2010). "MRG15 binds directly to PALB2 and stimulates homology-directed repair of chromosomal breaks". Journal of Cell Science. 123 (Pt 7): 1124–30. doi: 10.1242/jcs.060178. PMC 2844321. PMID 20332121.
Melzer D, Perry JR, Hernandez D, Corsi AM, Stevens K, Rafferty I, et al. (May 2008). "A genome-wide association study identifies protein quantitative trait loci (pQTLs)". PLOS Genetics. 4 (5): e1000072. doi: 10.1371/journal.pgen.1000072. PMC 2362067. PMID 18464913.
Hayakawa T, Ohtani Y, Hayakawa N, Shinmyozu K, Saito M, Ishikawa F, Nakayama J (June 2007). "RBP2 is an MRG15 complex component and down-regulates intragenic histone H3 lysine 4 methylation". Genes to Cells. 12 (6): 811–26. doi: 10.1111/j.1365-2443.2007.01089.x. PMID 17573780. S2CID 10003129.
Guil S, Soler M, Portela A, Carrère J, Fonalleras E, Gómez A, Villanueva A, Esteller M (June 2012). "Intronic RNAs mediate EZH2 regulation of epigenetic targets". Nature Structural & Molecular Biology. 19 (7): 664–70. doi: 10.1038/nsmb.2315. PMID 22659877. S2CID 14906359.
Huang X, Spencer GJ, Lynch JT, Ciceri F, Somerville TD, Somervaille TC (May 2014). "Enhancers of Polycomb EPC1 and EPC2 sustain the oncogenic potential of MLL leukemia stem cells". Leukemia. 28 (5): 1081–91. doi: 10.1038/leu.2013.316. PMC 3998875. PMID 24166297.

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