From Wikipedia, the free encyclopedia
Protein-coding gene in the species Homo sapiens
Echinoderm microtubule-associated protein-like 4 is a
protein that in humans is encoded by the EML4
gene .
[5]
This protein is involved in cancers when spliced with the
anaplastic lymphoma kinase .
[6]
References
^
a b c
GRCh38: Ensembl release 89: ENSG00000143924 –
Ensembl , May 2017
^
a b c
GRCm38: Ensembl release 89: ENSMUSG00000032624 –
Ensembl , May 2017
^
"Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^
"Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^
"Entrez Gene: EML4 echinoderm microtubule associated protein like 4" .
^ Choi YL, Takeuchi K, Soda M, Inamura K, Togashi Y, Hatano S, Enomoto M, Hamada T, Haruta H, Watanabe H, Kurashina K, Hatanaka H, Ueno T, Takada S, Yamashita Y, Sugiyama Y, Ishikawa Y, Mano H (July 2008).
"Identification of novel isoforms of the EML4-ALK transforming gene in non-small cell lung cancer" . Cancer Res . 68 (13): 4971–6.
doi :
10.1158/0008-5472.CAN-07-6158 .
PMID
18593892 .
Further reading
Andersson B, Wentland MA, Ricafrente JY, et al. (1996). "A "double adaptor" method for improved shotgun library construction". Anal. Biochem . 236 (1): 107–13.
doi :
10.1006/abio.1996.0138 .
PMID
8619474 . Yu W, Andersson B, Worley KC, et al. (1997).
"Large-scale concatenation cDNA sequencing" . Genome Res . 7 (4): 353–8.
doi :
10.1101/gr.7.4.353 .
PMC
139146 .
PMID
9110174 . Heidebrecht HJ, Buck F, Pollmann M, et al. (2000). "Cloning and localization of C2orf2(ropp120), a previously unknown WD repeat protein". Genomics . 68 (3): 348–50.
doi :
10.1006/geno.2000.6301 .
PMID
10995578 . Strausberg RL, Feingold EA, Grouse LH, et al. (2003).
"Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–903.
Bibcode :
2002PNAS...9916899M .
doi :
10.1073/pnas.242603899 .
PMC
139241 .
PMID
12477932 . Ota T, Suzuki Y, Nishikawa T, et al. (2004).
"Complete sequencing and characterization of 21,243 full-length human cDNAs" . Nat. Genet . 36 (1): 40–5.
doi :
10.1038/ng1285 .
PMID
14702039 . Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004).
"Large-scale characterization of HeLa cell nuclear phosphoproteins" . Proc. Natl. Acad. Sci. U.S.A . 101 (33): 12130–5.
Bibcode :
2004PNAS..10112130B .
doi :
10.1073/pnas.0404720101 .
PMC
514446 .
PMID
15302935 . Gerhard DS, Wagner L, Feingold EA, et al. (2004).
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)" . Genome Res . 14 (10B): 2121–7.
doi :
10.1101/gr.2596504 .
PMC
528928 .
PMID
15489334 . Rush J, Moritz A, Lee KA, et al. (2005). "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells". Nat. Biotechnol . 23 (1): 94–101.
doi :
10.1038/nbt1046 .
PMID
15592455 .
S2CID
7200157 . Hillier LW, Graves TA, Fulton RS, et al. (2005).
"Generation and annotation of the DNA sequences of human chromosomes 2 and 4" . Nature . 434 (7034): 724–31.
Bibcode :
2005Natur.434..724H .
doi :
10.1038/nature03466 .
PMID
15815621 . Pollmann M, Parwaresch R, Adam-Klages S, et al. (2006). "Human EML4, a novel member of the EMAP family, is essential for microtubule formation". Exp. Cell Res . 312 (17): 3241–51.
doi :
10.1016/j.yexcr.2006.06.035 .
PMID
16890222 . Olsen JV, Blagoev B, Gnad F, et al. (2006).
"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks" . Cell . 127 (3): 635–48.
doi :
10.1016/j.cell.2006.09.026 .
PMID
17081983 .
S2CID
7827573 . Ewing RM, Chu P, Elisma F, et al. (2007).
"Large-scale mapping of human protein-protein interactions by mass spectrometry" . Mol. Syst. Biol . 3 (1): 89.
doi :
10.1038/msb4100134 .
PMC
1847948 .
PMID
17353931 .
External links Overview of all the structural information available in the
PDB for
UniProt :
Q9HC35 (Human Echinoderm microtubule-associated protein-like 4 (EML4)) at the
PDBe-KB .
Echinoderm microtubule-associated protein-like proteins
