E281 References

Sodium propionate^[1]
Names
	Preferred IUPAC name Sodium propanoate
	Other names Sodium propionate; Napropion; E281
Identifiers
CAS Number	137-40-6 ;
3D model ( JSmol)	Interactive image;
ChEBI	CHEBI:132106 ;
ChEMBL	ChEMBL500826 ;
ChemSpider	8399 ;
ECHA InfoCard	100.004.810
EC Number	205-290-4;
E number	E281 (preservatives)
PubChem CID	8724;
UNII	DK6Y9P42IN ;
CompTox Dashboard ( EPA)	DTXSID7021996 ;
	InChI InChI=1S/C3H6O2.Na/c1-2-3(4)5;/h2H2,1H3,(H,4,5);/q;+1/p-1 Key: JXKPEJDQGNYQSM-UHFFFAOYSA-M ; InChI=1/C3H6O2.Na/c1-2-3(4)5;/h2H2,1H3,(H,4,5);/q;+1/p-1 Key: JXKPEJDQGNYQSM-REWHXWOFAH;
	SMILES [Na+].[O-]C(=O)CC;
Properties
Chemical formula	C3H5NaO2
Molar mass	96.060 g/mol
Appearance	Transparent crystals
Odor	faint acetic-butyric odor
Melting point	289 °C (552 °F; 562 K)
Solubility in water	1 g/ml
Solubility in ethanol	41.7 g/L
Pharmacology
ATC code	S01AX10 ( WHO) QA16QA02 ( WHO)
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). verify ( what is ?) Infobox references

Sodium propanoate or sodium propionate is the sodium salt of propionic acid which has the chemical formula Na( C₂ H₅ C O O). This white crystalline solid is deliquescent in moist air.

Reactions

It is produced by the reaction of propionic acid and sodium carbonate or sodium hydroxide.

Uses

It is used as a food preservative and is represented by the food labeling E number E281 in Europe; it is used primarily as a mold inhibitor in bakery products. It is approved for use as a food additive in the EU,^[2] USA^[3] and Australia and New Zealand^[4] (where it is listed by its INS number 281).

Structure

Anhydrous sodium propionate is a polymeric structure, featuring trigonal prismatic Na⁺ centers bonded to six oxygen ligands provided by the carboxylates. A layered structure is observed, with the hydrophobic ethyl groups projecting into the layered galleries. With hydrated sodium propionate, some of these Na-carboxylate linkages are displaced by water.

References

^ Merck Index, 11th Edition, 8623.
^ UK Food Standards Agency: "Current EU approved additives and their E Numbers". Retrieved 2011-10-27.
^ US Food and Drug Administration: "Listing of Food Additives Status Part II". Food and Drug Administration. Retrieved 2011-10-27.
^ Australia New Zealand Food Standards Code "Standard 1.2.4 - Labelling of ingredients". Retrieved 2011-10-27.
^ Fábry, Jan; Samolová, Erika (2020). "Layered alkali propanoatesM+(C2H5COO)−;M+= Na+, K+, Rb+, Cs+". Acta Crystallographica Section E. 76 (9): 1508–1513. Bibcode: 2020AcCrE..76.1508F. doi: 10.1107/S2056989020011469. PMC 7472758. PMID 32939309.

External links

Sodium propanoate at Sci-toys.com

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[1] Merck Index, 11th Edition, 8623.

[2] UK Food Standards Agency: "Current EU approved additives and their E Numbers". Retrieved 2011-10-27.

[3] US Food and Drug Administration: "Listing of Food Additives Status Part II". Food and Drug Administration. Retrieved 2011-10-27.

[4] Australia New Zealand Food Standards Code "Standard 1.2.4 - Labelling of ingredients". Retrieved 2011-10-27.

[5] Fábry, Jan; Samolová, Erika (2020). "Layered alkali propanoatesM+(C2H5COO)−;M+= Na+, K+, Rb+, Cs+". Acta Crystallographica Section E. 76 (9): 1508–1513. Bibcode: 2020AcCrE..76.1508F. doi: 10.1107/S2056989020011469. PMC 7472758. PMID 32939309.

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v t e Ophthalmologicals: anti-infectives ( S01A)
Antibiotics	amphenicols ( Chloramphenicol Azidamfenicol) tetracyclines ( Tetracycline Chlortetracycline Oxytetracycline) aminoglycosides ( Dihydrostreptomycin Neomycin Framycetin Kanamycin Amikacin Tobramycin Gentamicin Netilmicin Micronomicin) macrolides ( Erythromycin Natamycin) beta-lactams ( Ampicillin Benzylpenicillin) polypeptides ( Polymyxin B Tyrothricin) Rifamycin Fusidic acid
Sulfonamides	Sulfamethizole Sulfafurazole Sulfadicramide Sulfacetamide Sulfafenazol
Antivirals	Idoxuridine Trifluridine Aciclovir Interferon Vidarabine Famciclovir Fomivirsen Ganciclovir
Other	Nitrofural Bibrocathol Resorcinol Sodium borate Hexamidine Chlorhexidine Sodium propionate Ofloxacin Norfloxacin Ciprofloxacin Dibrompropamidine Propamidine Picloxydine Lomefloxacin Povidone-iodine Levofloxacin ( +dexamethasone) Gatifloxacin

Names

Preferred IUPAC name Sodium propanoate
Other names Sodium propionate Napropion E281
Identifiers
CAS Number	137-40-6^Y
3D model ( JSmol)	Interactive image
ChEBI	CHEBI:132106^N
ChEMBL	ChEMBL500826^Y
ChemSpider	8399^Y
ECHA InfoCard	100.004.810
EC Number	205-290-4
E number	E281 (preservatives)
PubChem CID	8724
UNII	DK6Y9P42IN^Y
CompTox Dashboard ( EPA)	DTXSID7021996
InChI InChI=1S/C3H6O2.Na/c1-2-3(4)5;/h2H2,1H3,(H,4,5);/q;+1/p-1^Y Key: JXKPEJDQGNYQSM-UHFFFAOYSA-M^Y InChI=1/C3H6O2.Na/c1-2-3(4)5;/h2H2,1H3,(H,4,5);/q;+1/p-1 Key: JXKPEJDQGNYQSM-REWHXWOFAH
SMILES [Na+].[O-]C(=O)CC
Properties
Chemical formula	C₃H₅NaO₂
Molar mass	96.060 g/mol
Appearance	Transparent crystals
Odor	faint acetic-butyric odor
Melting point	289 °C (552 °F; 562 K)
Solubility in water	1 g/ml
Solubility in ethanol	41.7 g/L
Pharmacology
ATC code	S01AX10 ( WHO) QA16QA02 ( WHO)
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). N verify ( what is ^YN ?) Infobox references

Reactions

Uses

Structure

See also

References

External links