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Chemical compound
Manogepix
Other names E1210, APX001A
ATC code
3-(3-(4-((pyridin-2-yloxy)methyl)benzyl)isoxazol-5-yl)pyridin-2-amine
CAS Number
PubChem
CID
ChemSpider
UNII
ChEMBL
Formula C 12 H 18 N 4 O 2
Molar mass 250.302 g·mol−1 3D model (
JSmol )
c1ccnc(c1)OCc2ccc(cc2)Cc3cc(on3)c4cccnc4N
InChI=1S/C21H18N4O2/c22-21-18(4-3-11-24-21)19-13-17(25-27-19)12-15-6-8-16(9-7-15)14-26-20-5-1-2-10-23-20/h1-11,13H,12,14H2,(H2,22,24)
Key:WSEKTEUGRLFBSE-UHFFFAOYSA-N
Manogepix (E1210 ) is an pyridine-
isoxazole -based broad-spectrum
antifungal .
[1] Manogepix targets an enzyme involved in the
post-translational modification of fungal proteins.
Manogepix is the
active metabolite of the
prodrug
fosmanogepix .
[2]
References
^ Pfaller MA, Hata K, Jones RN, Messer SA, Moet GJ, Castanheira M (October 2011). "In vitro activity of a novel broad-spectrum antifungal, E1210, tested against Candida spp. as determined by CLSI broth microdilution method". Diagnostic Microbiology and Infectious Disease . 71 (2): 167–170.
doi :
10.1016/j.diagmicrobio.2011.05.001 .
PMID
21696907 .
^ Badali H, Patterson HP, Sanders CJ, Mermella B, Gibas CF, Ibrahim AS, et al. (May 2021).
"Manogepix, the Active Moiety of the Investigational Agent Fosmanogepix, Demonstrates In Vitro Activity against Members of the Fusarium oxysporum and Fusarium solani Species Complexes" . Antimicrobial Agents and Chemotherapy . 65 (6).
doi :
10.1128/AAC.02343-20 .
PMC
8315997 .
PMID
33722886 .