The Driftless Area is a region in southwestern Wisconsin, southeastern Minnesota, northeastern Iowa, and the extreme northwestern corner of Illinois, of the American Midwest. The region escaped the flattening effects of glaciation during the last ice age and is consequently characterized by steep, forested ridges, deeply carved river valleys, and karst geology characterized by spring-fed waterfalls and cold-water trout streams. Ecologically, the Driftless Area's flora and fauna are more closely related to those of the Great Lakes region and New England than those of the broader Midwest and central Plains regions. Colloquially, the term includes the incised Paleozoic Plateau of southeastern Minnesota and northeastern Iowa.  The region includes elevations ranging from 603 to 1,719 feet (184 to 524 m) at Blue Mound State Park and covers 24,000 square miles (62,200 km2).  The rugged terrain is due both to the lack of glacial deposits, or drift, and to the incision of the upper Mississippi River and its tributaries into bedrock.
An alternative, less restrictive definition of the Driftless Area includes the sand Plains region northeast of Wisconsin's portion of the incised Paleozoic Plateau in the southwestern part of the state. This part of the Driftless Area in the southwestern section of Wisconsin's Central Plain also lacks evidence of glaciation (although it was modified by glacial meltwaters that collected in Glacial Lake Wisconsin), and contains many isolated hills, bluffs, mesas, buttes, and pinnacles that are outlying eroded Cambrian bedrock remnants of the plateau to the southwest.
Retreating glaciers leave behind material called drift composed of silt, clay, sand, gravel, and boulders. Glacial drift includes unsorted material called till and layers deposited by meltwater streams called outwash.  While drift from early ( pre-Illinoian) glaciations has been found in some parts of the region,    much of the incised Paleozoic Plateau of Wisconsin and northwestern Illinois has no evidence of glaciation.
Numerous glacial advances throughout the world occurred during the most recent Quaternary glaciation (also known as the Pleistocene glaciation). The Upper Midwest and Great Lakes region of North America was repeatedly covered by advancing and retreating glaciers throughout this period. The Driftless Area escaped much of the scouring and depositional action by the continental glaciers that occurred during the last ice age, which created significant differences in the topography and drainage patterns within the unglaciated area compared to adjacent glaciated regions.
The region has been subjected to large floods from the melting Laurentide Ice Sheet and subsequent catastrophic discharges from its proglacial lakes, such as Glacial Lake Wisconsin, Glacial Lake Agassiz, Glacial Lake Grantsburg, and Glacial Lake Duluth.
The last phases of the Wisconsin Glaciation involved several major lobes of the Laurentide Ice Sheet: the Des Moines lobe, which flowed down toward Des Moines on the west; the Superior lobe and its sublobes on the north; and the Green Bay lobe and Lake Michigan lobes on the east.  The northern and eastern lobes were in part diverted around the area by the Watersmeet Dome, an ancient uplifted area of Cambrian rock underlain by basalt in northern Wisconsin and western upper Michigan. The southward movement of the continental glacier was also hindered by the great depths of the Lake Superior basin and the adjacent highlands of the Bayfield Peninsula, Gogebic Range, Porcupine Mountains, Keweenaw Peninsula, and the Huron Mountains along the north rim of the Superior Upland bordering Lake Superior. The Green Bay and Lake Michigan lobes were also partially blocked by the bedrock of the Door Peninsula, which presently separates Green Bay from Lake Michigan.  In earlier phases of the Wisconsinan, the Driftless Area was totally surrounded by ice, with eastern and western lobes joining together to the south of it.
Another factor that may have contributed to the lack of glaciation of the Driftless area is the fractured, permeable bedrock within the paleozoic plateau underlying it, which would have promoted below-ground drainage of subglacial water that would otherwise have lubricated the underside of the glacial ice sheet. The dewatering of the underside of the ice sheet would have inhibited forward movement of the glacier into the Driftless Area, especially from the west.
The latest concept explaining the origin of the Driftless Area is the pre-Illinoian continental glacial ice flowing over the Driftless Area and depositing on it pre-Illinoian till, which is more than 790,000 years old. When the ice retreated and uncovered the area, intensive periglacial erosion removed it. Anticyclonic snow-bearing winds episodically dropped large amounts of snow, which then gradually removed superficial sediment from slopes by solifluction and snowmelt overland flow (sheetwash), washing the deposits down to stream valleys that ultimately flowed into the Mississippi River. 
In the adjacent glaciated regions, the glacial retreat left behind drift, which buried all former topographical features. Surface water was forced to carve out new stream beds.  This process was absent in the Driftless Area, where the original Drainage systems persisted during and after the ice age. Water erosion continued carving the existing gullies, ravines, stream beds, and river valleys ever deeper into the paleozoic plateau, following the original drainage patterns.
Overall the region is characterized by an eroded plateau with bedrock overlain by varying thicknesses of loess. Most characteristically, the river valleys are deeply dissected. The bluffs lining this reach of the Mississippi River currently climb to nearly 600 feet (180 m). In Minnesota, pre-Illinoian-age till was probably removed by natural means prior to the deposition of loess. The sedimentary rocks of the valley walls date to the Paleozoic Era and are often covered with colluvium or loess.  Bedrock, where not directly exposed, is very near the surface and is composed of "primarily Ordovician dolomite, limestone, and sandstone in Minnesota, with Cambrian sandstone, shale, and dolomite exposed along the valley walls of the Mississippi River."  In the east, the Baraboo Range, an ancient, profoundly eroded monadnock in south central Wisconsin, consists primarily of Precambrian quartzite and rhyolite. The area has not undergone much tectonic action, as all the visible layers of sedimentary rock are approximately horizontal.
Karst topography is found throughout the Driftless area. This is characterized by caves and cave systems, disappearing streams, blind valleys, underground streams, sinkholes, springs, and cold streams. Disappearing streams occur where surface waters sinks down into the earth through fractured bedrock or a sinkhole, either joining an aquifer, or becoming an underground stream. Blind valleys are formed by disappearing streams and lack an outlet to any other stream. Sinkholes result from the collapse of a cave's roof, and surface water can flow directly into them. Disappearing streams can reemerge as large cold springs. Cold streams with cold springs as their sources are superb trout habitat. Due to the rapid movement of underground water through regions with karst topography, groundwater contamination is a major concern in the Driftless area.
As rivers and streams approach their confluence with the Mississippi, their canyons grow progressively steeper and deeper, particularly in the last 25 miles (40 km) in their journey to their mouths. The change in elevation above sea level from ridgetops lining a stream to its confluence with the Big River can reach well past 650 feet (200 m) in only a few miles. The Waukon Municipal Airport is reliably established as being 1,281 feet (390 m) above sea level.  The Army Corps of Engineers maintains a river level in Pool 9 of about 619 feet (189 m) above sea level,  which covers Lansing. Maps and signs issued by the Iowa Department of Transportation indicate Waukon and Lansing are 17 miles (27 km) apart on Iowa Highway 9. This is a drop of more than 660 feet (200 m) in less than 20 miles (32 km) (and this along a very minor tributary of the Mississippi). "The role of isostatic rebound on the process of stream incision in the area is not clearly understood." 
There are many small towns in the Driftless Area, especially in river valleys, at or upstream from the Mississippi. Small towns in a deep steep valley going down to the Mississippi are at risk every 50 to 100 years or so of a major flood, as with the wreck of Gays Mills, Wisconsin, in August 2007, or the holding of the levee in Houston, Minnesota, (on the South Fork Root River) at the same time. Metropolitan areas have flood walls (See 2007 Midwest flooding). In August 2018, the region yet again experienced record-breaking flooding in valley towns such as Coon Valley, Wisconsin, La Farge, Wisconsin and Viola, Wisconsin. The Kickapoo River flood stage is 13 feet but was recorded as high as 23 feet during the 2018 flood which was declared a statewide emergency.  Many community members were rescued by boat from the Wisconsin Department of Natural Resources.  Days later when two dams in Ontario, Wisconsin broke it created flood water downstream in Readstown, Wisconsin, Soldiers Grove, Wisconsin and Gays Mills, Wisconsin. 
The history of this portion of the Upper Mississippi River dates back to an origin "as an ice-marginal stream during what had been referred to as the “ Nebraskan glaciation.”" Current terminology would place this outdated and abandoned period in the Pre-Illinoian Stage.  The level of erosion often exposes Cambrian limestone of about 510 million years of age.  Evidence from soil borings and recent Lidar imagery in the lower Wisconsin River valley in the Driftless area suggests that the river in the valley used to flow towards the east, rather than its present westerly course towards its confluence with the Mississippi River. This has led to the new hypothesis that the ancient Upper Mississippi River (also named the Wyalusing River) at one time flowed east through the current Wisconsin River valley and into the Great Lakes/ Saint Laurence River system somewhere near the Door Peninsula. The hypothesis posits that the flow of the ancient Wyalusing River was ultimately captured by the ancestral Mississippi River to the south when that river eroded through the Military Ridge near Wyalusing State Park, possibly as a result of an ancient ice sheet in a previous continental glaciation blocking the Wyalusing River to the east. The resulting Proglacial lake would have filled the Wyalusing River valley until it overtopped the Military Ridge, ultimately carving through the ridge and draining the lake. This resulted in the ancient Upper Mississippi River changing course and flowing south towards the Gulf of Mexico as it does currently instead of east into the Saint Lawrence River and the North Atlantic Ocean. The Stream capture hypothesis for the Upper Mississippi River would have created a substantial diversion of water from the Great Lakes Basin and the Saint Lawrence River, reducing the inflow of fresh water into the North Atlantic with possible impacts to Ocean currents and Climate.
The Mississippi River trench is one of the few places in the Driftless Area where the bedrock is very deep below the surface, and is overlain by large amounts of sediment.  As home to the formation of a substantial portion of the gorge of the Upper Mississippi, this enormous quantity of sediment goes down at least 300 feet (91 m) under the present riverbottom at the confluence of the Wisconsin River.  In contrast, as the River exits the Driftless Area "between Fulton and Muscatine, [... ( Pool 13)], it flows over or near bedrock."  "The course of the upper Mississippi River along the margin of the Driftless Area of southeastern Minnesota is believed to have been established during pre-Wisconsin time when a glacial advance from the west displaced the river eastward from central Iowa to its present position." 
Other rivers affected by this geologic process are:
- In Wisconsin, the Chippewa, Trempealeau, La Crosse, Black, Baraboo, Pecatonica, and Wisconsin Rivers, along with the Wisconsin River's tributary, the Kickapoo River;
- In Minnesota: the Whitewater, Cannon, Zumbro, and Root rivers;
- In Iowa: the Upper Iowa (and Paint Creek), Yellow, Turkey, and Maquoketa rivers;
- In Illinois: the Apple River and the Galena River (a.k.a. the Fever River).
Although lying just to the north of the Driftless Area, the Saint Croix in Wisconsin and Minnesota is another important river that affected the area, as it was the outlet for Glacial Lake Duluth, forerunner to Lake Superior, when the eastern outlet was blocked by the continental ice sheet. All major rivers in and adjacent to the Driftless Area have deep, dramatic canyons giving testimony to the immense quantity of water which once surged through them as a result of the nearby melting Glaciers associated with the miles-high Ice sheets during recurring Ice ages. Other examples include the Wisconsin River, which drained Glacial Lake Wisconsin, and Glacial River Warren (whose bed is now occupied by the Minnesota River), which drained the colossal Glacial Lake Agassiz. There was ample water to dig a very deep, hundreds-of-miles-long gash into the North American bedrock where the Upper Mississippi River now flows.
The climate is humid continental, displaying both the cool summer and warm summer subtypes as one travels from north to south.  The United States Department of Agriculture has the region falling mainly in zone 5a, with the northern fringe being 4b. A few patches in Wisconsin are 4a.
Prior to European settlement in the 19th century, the vegetation consisted of tallgrass prairie and bur oak savanna on ridgetops and dry upper slopes, sugar maple- basswood- oak forest on moister slopes, sugar maple-basswood forests in protected valleys and on north-facing slopes, wet prairies along the rivers and some mesic prairie on the floodplain farther back from the river.[ citation needed] There were probably also oak forests that contained no sugar maple. Marsh and floodplain forests were also common on river flood plains. Prairie was restricted primarily to the broader ridge tops, which were unfavorable sites for trees due to thin soils and shallow bedrock, rapid drainage, and desiccating winds; all these conditions were also good for carrying fires across the landscape. Prairies also occurred on steep slopes with south or southwest aspect (see goat prairie ). Natural fire, which has long been vigorously suppressed, was essential for the regeneration of such prairies.
Evidence of ancient extinct ice age animals that once inhabited the Driftless Area has been discovered over the years. An example of extinct Pleistocene megafauna in the area is the Boaz Mastodon, a composite skeleton of two separate Mastodons found in the 1890s in southwestern Wisconsin. Although evidence exists that mastodons inhabited mostly coniferous Spruce forests associated with the Taiga Biome, it is likely that most or all of the Driftless Area was at times covered by Tundra and Permafrost during periods of glacial maximums.
The Midwest Driftless Area Restoration Effort is a multi-agency cooperative effort to restore the landscape.  The main issues are water pollution from agricultural and animal runoff, and erosion.[ citation needed] Many farmers in the region utilize Contour plowing, Strip Cropping, and other agricultural practices to reduce soil erosion due to the hilly terrain. Water pollution is particularly critical in karsted regions such as this, in that it can degrade or destroy prime cold water fish habitat. Soil erosion presents the Army Corps of Engineers with a particular problem, in that it requires them to dredge the Mississippi River shipping channels to keep them open. Trout Unlimited is part of this effort, if only because of the superb cold-water streams the region supports.  A symposium was held in October 2007 in Decorah, Iowa, "to share the results of research, management and monitoring work in the Driftless Area."  The Nature Conservancy is also interested.
The Driftless Area contains more than half of the world's algific talus slopes, a type of small, isolated ecosystem.  These refugia create cool summer and fall microclimates which host species usually found further north. They contain at least one endangered species, the Iowa Pleistocene Snail, and a threatened plant, the Northern monkshood.  The Driftless Area National Wildlife Refuge was primarily carved out of the Upper Mississippi River National Wildlife and Fish Refuge in order to protect these species and their associated ecosystems.
Isolated relic stands of pines and associated northern vegetation are found in some locations where algific talus slopes are present. These trees survive in the cooler Microclimate produced at these locations outside of their current range further north.
A particularly noteworthy annual event is the rising of fishflies, a kind of mayfly endemic to the Mississippi valley in the region. These are aquatic insects attracted to light, which rise by the millions as adults to mate, only to die within hours. 
Wildlife is abundant with opportunities for hunting whitetail deer and wild turkey. Fishing, particularly for brown trout, brook trout, and rainbow trout in tributaries, and species such as channel catfish in the Mississippi is available, with ice fishing in winter. 
The Driftless Area is part of the Mississippi Flyway. Many birds fly over the river in large flocks, going north in spring and south in autumn.
There are very few natural lakes in the region, these being found in adjoining areas of glacial till, drift and in moraines; the region is extraordinarily well drained, and there is rarely a place where even a pond can naturally form. There are also very few dams in that the valley walls and floors are very often fissured or crumbly, or very porous, providing very poor anchors for a dam or making it difficult to keep any kind of reservoir appropriately filled. There are no real waterfalls, but some very strong springs bear the name.
A modern, man-made characteristic is the comparatively twisty nature of highways in the region, such as in Kentucky, in contrast to the usually rigid east-west/north-south alignment elsewhere in the Midwest[ citation needed]. Here, the roads switchback up stream valleys or travel over ridge tops. The route of U.S. Highway 20 through the Driftless, and particularly in Illinois, is a good example.
The bioregion shares economic and cultural characteristics, as well. These were federally recognized with the granting of the Upper Mississippi River Valley viticultural area by the Treasury Division's Tax and Trade Bureau in 2009.  The UMRV is the largest designated winemaking region in the country. The petition for designation includes a 16-page narrative that spells out why this region is a cohesive whole for marketing wine, and is now used to market other products. 
At the University of Wisconsin-Madison, the Center for Integrated Agricultural System's Food and Farm project is working with the region's sustainable-agriculture farmers, processors, distributors, chefs, planning commissions, and others to define the culinary identity of the region and direct the development of agrotourism. For instance, 75% of the raw-milk artisan cheese produced in Wisconsin is made in the Driftless region. This cheese is made from milk produced by cows that graze on pastures. The region is home to Organic Valley, the nation's largest organic dairy cooperative. Generally, organic dairy production fits best with a grass-based milk production system. In addition to wine-grape production and wine-making, the region also is known for apple production, and a number of hard cider makers are about to hit the market. The region is historically known for grass-fed beef, and has great potential to market forest botanicals - especially mushrooms - to the 21 million people in the region, including the relatively nearby Minneapolis-St. Paul, Chicago, and Milwaukee markets.
Due to the presence of sandstone bedrock at or near the surface, sand mining is a growing industrial activity in portions of the Driftless Area. The sandstone contains quartz (silica) sand grains of the required hardness, shape, size, and purity that make it ideal for use in hydraulic fracturing utilized by the petroleum and natural gas industries during drilling operations. The mining activity involves quarrying the sandstone bedrock by blasting with dynamite, crushing the rock, washing, drying, and grading the resulting sand, and transporting the sand out of the region, usually by rail. The recent proliferation of sand mines in the region has created new jobs and economic activity. However, the growth of the industry has also created controversy due to opposition of nearby residents and environmentalists concerned about impacts to water and air quality (silica dust pollution), noise and light pollution, heavy truck traffic, and the destruction of the hills and ridges for which the region is known.
Corresponding to the southeast geological region of Minnesota, the colloquial "Driftless Area" (though the whole region was glaciated) begins at about Fort Snelling. Starting as a narrow sliver against the Mississippi, it widens to the west as one goes south. The western boundary is the Bemis-Altamont moraine.   Another more easily located reference to the western boundary is the approximate line of Minnesota State Highway 56.
The upland plateau lies west of the incised tributaries to the Mississippi. The historic vegetation was mixed woodland, with occasional goat prairies on southwesterly facing slopes.  In the western section is "an old plateau covered by loess [...] along the eastern border and pre-Wisconsin age glacial till in the central and western parts. The western portion is a gently rolling glacial till plain that is covered by loess in places." 
The counties involved include all or part of Dakota, Goodhue, Rice, Wabasha, Winona, Olmsted, Dodge, Houston, Fillmore, and Mower. Aside from the southeastern suburban sprawl of the Twin Cities, Rochester is the main urban area. Additional communities include Red Wing, Lake City, Winona, La Crescent, Chatfield, Lanesboro, Rushford, Houston and Caledonia.
Glacial River Warren, in whose bed the Minnesota River now flows, entered the "Driftless Area" just downriver from present-day Minneapolis-Saint Paul, at Fort Snelling, over River Warren Falls, "an impressive 2700 feet (823 m) across and 175 feet (53 m) tall, over 10 times as wide as Niagara falls"  (this has since receded to become Saint Anthony Falls). The region is characterized "by the absence of glacial drift deposits, the sculpted topography, and the presence of the ancient limestone immediately beneath the soil and in cliff outcroppings."  The Minnesota Driftless Area did not reach the Twin Cities or any areas to the north or west of them; rather, the Twin Cities marked the edge of glaciation, with substantial terminal moraines overlying the region. 
The largest protected area is Richard J. Dorer Memorial Hardwood State Forest, which contains some state-owned land, but is mostly private, controlled by state conservation easements.
Around 85% of the Driftless Area lies within Wisconsin, comprising much of the southwestern quarter of the state. The border is defined by the catchment of the Chippewa River on the north, and somewhat west (or east, depending on if the southwestern portion of Wisconsin's Central Plain is included) of the north-south line of the Wisconsin River. Where the Wisconsin River turns west to join the Mississippi, the area to the south, including the whole of Grant County as well as most of Lafayette County, are part of the Driftless Area.
The rugged terrain comprising most of the Driftless Area is distinct from the rest of Wisconsin, and is known locally as the Coulee Region. The steep ridges, numerous rock outcroppings, and deep, narrow valleys in the Driftless Area are in marked contrast with the rest of the state, where glaciers have modified the landscape. The hilly unglaciated landscape is well represented in Wisconsin's Coulee Experimental State Forest, Wildcat Mountain State Park, Governor Dodge State Park, and the Kickapoo Valley Reserve.
The Driftless Area is located in all or part of Pierce, Pepin, Eau Claire, Buffalo, Trempealeau, Jackson, La Crosse, Monroe, Juneau, Vernon, Richland, Sauk, Crawford, Iowa, Dane, Green, Grant, and Lafayette counties. If the less restrictive definition of the Driftless Area is used (which includes the unglaciated southwestern portion of Wisconsin's Central Plain), then Adams and portions of southern Wood and Portage counties are also included. La Crosse is the principal urban area wholly within the Driftless Area, while the larger Madison's far western suburbs are located on the edges of the area. Small cities and towns are scattered throughout the region. Numerous Amish settlements are also located within Wisconsin's Driftless Area.
The U.S. Army maintains a presence at Fort McCoy, Wisconsin in Monroe County between Sparta and Tomah immediately south of the Black River State Forest. The property is used mainly for military training exercises, although troops have also been based there for deployments overseas.
The Coulee Region portion of the Driftless Area comprises much of Wisconsin's Western Upland geographical region. The most rugged part of Wisconsin's Driftless area is also called the Ocooch Mountains.
Largely rural in character, land cover is forest, farmland, and grassland/pasture; modest wetlands are found in river valleys, and along the Mississippi.  Row crop farming is less encountered than elsewhere in the state.  Away from the Mississippi, Wisconsin, and other major rivers, much of the terrain is gently rolling, supporting dairy farms. In other areas, the rugged nature of the topography in the region is not conducive to farming, except on ridge tops and in river valleys. The sides of the ridges are often too steep for farming, and are usually forested. The Coulee Experimental State Forest near La Crosse was created in part to test soil conservation practices to prevent soil erosion in the hilly Driftless Area.
The northeastern portion of the Driftless area was covered by or bordered by Glacial Lake Wisconsin during the Wisconsin glaciation. The steep-sided rocky bluffs present in Roche-a-Cri State Park and Mill Bluff State Park are Cambrian outliers of the Franconia Cuesta to the southwest and were once islands or sea Stacks in the ancient lake. The flat plain in which these bluffs lie is located in the southwest portion of Wisconsin's Central Plain geographic region, and was created in part by sediments falling to the bottom of Glacial Lake Wisconsin. This flat plain consists of sandy deposits and contains many Bogs that were left over from Glacial Lake Wisconsin. Many of these bogs have been converted into cranberry marshes, helping to make Wisconsin a leader in cranberry production. The remainder of the sand plain consists of forest and irrigated farmland. The Dells of the Wisconsin River were carved through the bedrock during the sudden draining of Glacial Lake Wisconsin at the end of the last Ice age.
Due to the lack of natural lakes in the Coulee region, several large artificial lakes have been created for flood control and recreational purposes, including Dutch Hollow Lake and Lake Redstone in Sauk County, Blackhawk Lake in Iowa County, and Yellowstone Lake (in Yellowstone State Park) in Lafayette County. Plans for a large Reservoir on the Kickapoo River at La Farge, Wisconsin were dropped in 1975 after much controversy due to cost-benefit and environmental concerns. Land previously acquired for the reservoir became the Kickapoo Valley Reserve, an 8,569 acre public forest and wildlife area.
Wazee Lake, at 355 feet (108 m) deep, is Wisconsin's deepest inland lake, and is located in Jackson County in the northeast portion of the Driftless area. The artificial lake lies in the former open pit Jackson County Iron Mine and is the centerpiece of the Wazee Lake Recreation Area. Due to its great depth, vertical underwater cliffs, clear water, and submerged mining features, the lake is popular with scuba divers.
During the 19th and early 20th centuries, Lead and Zinc mining was a major industrial activity in the Driftless Area, drawing many foreign immigrants to settle in the region to work in the mines. Early miners often lived in the mine tunnels, leading outsiders to compare them to the burrowing Badger; a nickname that eventually came to be used for all Wisconsin residents. An example of an early lead Shot tower and smelting house is preserved in Tower Hill State Park.
Due to the influx of early miners, the lead mining region became Wisconsin's most populous area at the time. The first capitol of the Wisconsin Territory was located for a short time at Belmont, Lafayette County in the heart of the lead mining region. The site of the first capitol is preserved in First Capitol Historic Site.
Three units of the Ice Age National Scientific Reserve are located within or adjacent to the Driftless Area: Devil's Lake State Park, Mill Bluff State Park, and Cross Plains State Park. In addition, the Ice Age Trail follows the Terminal moraine of the maximum glacial extent from the last ice age and enters the Driftless Area in several locations.
Other notable natural features include the Baraboo Range (consisting of two heavily forested, steep, rocky Quartzite ridges with mountain-type scenery), rock formations in Natural Bridge State Park (Wisconsin), the forested bluffs, floodplains, islands, and sandbars in the Lower Wisconsin River State Riverway, the confluence of the Wisconsin River with the Mississippi River at Wyalusing State Park, Trempealeau Mountain State Natural Area in the Mississippi River valley at Perrot State Park, and the gorge and rock formations surrounding the Wisconsin River at the Dells of the Wisconsin River. The Black River State Forest protects a large area of North Woods, rocky bluffs, sandy plains, and river shoreline on the northeastern edge of the driftless area that provides habitat for several Wolf packs and one of Wisconsin's reintroduced elk herds.
The contrast between what the rest of Iowa looks like and what the Driftless Area presents is remarkable.  For counties inland from the Mississippi, the evidence is largely confined to the valleys of streams and rivers. It encompasses all of Allamakee, and part of Clayton, Fayette, Delaware, Winneshiek, Howard, Dubuque, and Jackson counties. Dubuque is the only metropolitan area.
The region is distinct from the "Iowan Erosion Surface to the west and the Southern Iowa Drift Plain to the south."  A line east of the most easterly tributaries of the Wapsipinicon River defines the terminal moraine that marks the western boundary of the Driftless, with the catchment of the Maquoketa River south of Bellevue serving as a southern boundary. The most western tributaries of the Upper Iowa, Yellow and Turkey Rivers flow east and south from the vicinity of this moraine.
Outside of Dubuque, this region of Iowa is thinly populated. In the western section, agriculture and livestock raising are the norm. As one travels east, and as the valleys tumble down to the Mississippi, much of the land is virtually wild, with a great deal of it publicly owned. The state maintains an extensive number of wildlife management areas, along with state forests and state parks.
The most impressive area is on the Mississippi, between Pikes Peak State Park, opposite the Wisconsin River down to Guttenberg, where bluffs lining the river reach their maximum height. This is apparently an Iowa continuation of Military Ridge, a catchment-defining divide in Wisconsin that was used for the Military Ridge Road, a portion of which is included in Military Ridge State Trail, both across the River in Wisconsin.
Effigy Mounds National Monument is at the heart of a network of adjacent parks, state forests, preserves, as well as national wildlife refuges, all of which preserve and illustrate the features of the Driftless, where "patchy remnants of Pre-Illinoian glacial drift more than 500,000 years old recently have been discovered in the area."  Additional protected areas are Cold Water Spring State Preserve near Decorah, Maquoketa Caves State Park northwest of Maquoketa, Bellevue State Park adjacent to Bellevue, White Pine Hollow State Forest (which protects Iowa's only remaining groves of old-growth white pine trees) near Dubuque, and the Yellow River State Forest in the southeastern corner of Allamakee County, Iowa.
The Illinois portion of the Driftless Area is confined mainly to Jo Daviess County; western parts of Carroll County (the Mississippi River bluffs characteristic of the Driftless terminate around Savanna) and a tiny portion of northwest Whiteside County are also included.  The region contains the highest points in the state, of which "the most notable are Charles Mound and Benton Mound, rising to heights of 1,246 feet (380 m) and 1,226 feet (374 m) respectively."  The region "has many sinkholes and sinkhole ponds." 
The valley of the Apple River has a major canyon, with Apple River Canyon occupying much of it. The mouth of this river, near Hanover adjacent to the former Savanna Army Depot, comes close to the southern end of the Driftless Area on the eastern side of the Mississippi (see Lock and Dam No. 13).
- "Regional Landscape Ecosystems of Michigan, Minnesota, and Wisconsin: Section IV. Driftless Area" Archived 2008-03-27 at the Wayback Machine, USGS, Retrieved July 13, 2007; another government site, "Driftless Area Initiative" Archived 2008-03-28 at the Wayback Machine, USDA, retrieved July 15, 2007, gives 24,103 square miles (62,430 km2) and 15,425,063 acres (6,242,302 ha)
- U.S. Department of Agriculture Natural Resources Conservation Service. Driftless Area Landscape Conservation Initiative. Retrieved August 25, 2017.
- "The Driftless Area" Archived 2007-08-25 at the Wayback Machine, Minnesota Conservation Volunteer, March 2007 (popular article from the Minnesota Department of Natural Resources (MDNR)), Retrieved July 7, 2007
- "Yellow River State Forest" Archived July 14, 2007, at the Wayback Machine, Iowa Department of Natural Resources (IDNR), Retrieved July 7, 2007
- Byron Crowns. "Wisconsin through 5 Billion Years of Change", Wisconsin Earth Science Center, 1976, Wisconsin Rapids, Wisconsin, p. 131, LCCN 76-46151
-  Archived May 3, 2007, at the Wayback Machine
- Iannicelli, Michael (2010). "Evolution of the Driftless Area and Contiguous Regions of Midwestern USA Through Pleistocene Periglacial Processes". The Open Geology Journal. 4 (1): 35–54. Bibcode: 2010OGJ.....4...35I. doi: 10.2174/1874262901004010035.
- "Native American use of the Mississippi River". Archaeology Education Program, vol. 22, no. 2 (Fall 2004):1. Retrieved January 25, 2018.
- Regional Landscape Ecosystems of Michigan, Minnesota, and Wisconsin, Section IV, Driftless Area Archived 2008-03-27 at the Wayback Machine, National Park Service, Retrieved July 9, 2007 (A statement from this copyright-free site has been freely paraphrased.)
- "Y01 - Waukon Municipal Airport". AirNav.com. AirNav, LLC. Retrieved May 1, 2014.
- "Station Information for Mississippi River at Lock and Dam 9 (Lynxville, WI)". Rivergages.com. Army Corps of Engineers. Retrieved May 1, 2014.
- Stephanie A. Tassier-Surine, ( Iowa Department of Natural Resources, Geological Survey Bureau), Quaternary Geology of the Paleozoic Plateau Region of Northeastern Iowa Archived 2011-07-26 at the Wayback Machine, Retrieved July 30, 2007
- "Walker Declares Statewide Emergency After Storms Ravage Communities". Wisconsin Public Radio. 2018-08-29. Retrieved 2019-02-06.
- Tribune, Mike Tighe La Crosse. "La Farge grapples not only with flooding but also no power". La Crosse Tribune. Retrieved 2019-02-06.
- Broadcaster, Angela Cina Vernon County. "Vernon County's Jersey Valley, Mlsna dams fail due to heavy rains". La Crosse Tribune. Retrieved 2019-02-06.
- Watershed Description (of the Upper Iowa River, Northeastiowarcd.org, Retrieved August 5, 2007
- [ dead link]
- "Geology of Pikes Peak State Park Archived 2007-07-11 at the Wayback Machine, Iowa Department of Natural Resources, Retrieved July 13, 2007
- Charles Theiling, "River Geomorphology and Floodplain Habitats", p. 1 (*.pdf), USGS, Retrieved July 12, 2007
- Thomas Madigan, "The Geology of the MNRRA Corridor", p. 26, National Park Service, Retrieved July 23, 2007
- Michael E. Ritter, "Humid Continental Climate" Archived May 30, 2007, at the Wayback Machine, University of Wisconsin–Stevens Point, 2006, Retrieved August 11, 2007
- "Driftless Area Restoration Effort". Trout Unlimited. Retrieved May 1, 2014.
-  Archived March 26, 2008, at the Wayback Machine
- “Science in the Driftless Area”, Announcement and Call for Papers, Deadline August 24, 2007 Archived March 26, 2008, at the Wayback Machine (press release), Again retrieved with different URL, November 16, 2007
- Epstein, E.E. (2017). "Natural communities, aquatic features, and selected habitats of Wisconsin" (PDF). The ecological land- scapes of Wisconsin: An assessment of ecological resources and a guide to planning sustainable management. Wisconsin Department of Natural Resources. Retrieved 1 October 2018.
- Driftless Area National Wildlife Refuge Comprehensive Conservation Plan, U.S. Fish and Wildlife Service, Retrieved July 23, 2007 Superb site, but Beware, this is a very long PDF document
- Parfin, Sophy I. (1952). "The Megaloptera and Neuroptera of Minnesota". The American Midland Naturalist. University of Notre Dame. 47 (2): 421–34. doi: 10.2307/2422271. ISSN 1938-4238. JSTOR 2422271.; other more anecdotal sites give a fuller feeling for the scope of the annual invasion, e.g., Wonderful Wacky Water Critters Archived 2007-08-10 at the Wayback Machine Retrieved August 8, 2007
- Dahlke 2018-10-01T12:55:00-04:00, Josh. "Fishing the Driftless Area: The Best Kept Secret in the Trout World". Outdoor Life. Retrieved 2019-04-09.
- "Upper Mississippi River Valley American Viticulture Area". Upper Mississippi River Valley Association. Retrieved May 1, 2014.
- Miller, Michelle (June 6, 2011). "American Viticultural Area Petition For Upper Mississippi River Valley". Upper Mississippi River Valley Appellation Committee. Retrieved May 1, 2014.
- ""Glacial Geology of the "Driftless Region"". Archived from the original on March 28, 2008. Retrieved July 9, 2007.
- "Rochester Plateau Subsection", Minnesota Department of Natural Resources, Retrieved July 23, 2007
- "ECS: Paleozoic Plateau Section: Minnesota DNR". Dnr.state.mn.us. Retrieved 2015-03-01.
- Scott Anfinson, "Archaeology of the Central Minneapolis Riverfront", The Institute for Minnesota Archaeology, 1989, Retrieved July 8, 2007
- Nancy Kleven, "The Driftless Area Of Minnesota", Winter 1989, Minnesota Plant Press, 8(2) (online)
- "Map of moraines in Twin Cities area". Winona.edu. Retrieved 2015-03-01.
- "Blufflands and Driftless Area", Natural Resources Foundation of Wisconsin, Retrieved July 30, 2007
- Regional Assessment of the Wisconsin Driftless Natural Division Archived 2007-08-10 at the Wayback Machine, Illinois Department of Natural Resources, Retrieved July 30, 2007
- Statistical Information on Wisconsin (PDF). State of Wisconsin Blue Book 2005 − 2006. Wisconsin Legislative Reference Bureau. July 2005. pp. 691–694. Archived from the original (PDF) on March 24, 2009. Retrieved May 1, 2014.
- Find Maps | Find Maps Archived 2009-01-05 at the Wayback Machine. Sco.wisc.edu. Retrieved on July 21, 2013.
- "Landforms of Iowa" (PDF). Uni.edu. Retrieved 2015-03-01.
- "Effigy Mounds Historic Resource Study", Chapter 3, Environment Archived 2007-05-19 at the Wayback Machine, National Park Service, Retrieved July 8, 2007
- "Charles". NGS data sheet. U.S. National Geodetic Survey. Retrieved 2008-12-17.
- "Illinois Natural History Survey, 1996". Inhs.uiuc.edu. Retrieved July 7, 2007.
- "Driftless Area Critical Trends Assessment: The Area at a Glance". Illinois Department of Natural Resources. Archived from the original on July 14, 2014. Retrieved July 9, 2014.
- "Illinois' Natural Divisions" Archived 2008-01-12 at the Wayback Machine, Illinois Department of Natural Resources, Retrieved July 12, 2007
|Wikivoyage has a travel guide for Driftless Area.|
- A Sand County Almanac: A book written by Aldo Leopold about the flora and fauna in the Coulee region.
- The Driftless Area: A Landscape of Opportunities
- "Driftless Area National Wildlife Refuge", Retrieved July 23, 2007
- US Geological Survey description Retrieved July 7, 2007
- National atlas description and map Retrieved July 7, 2007
- Driftless Area Initiative Retrieved July 2, 2014
- Wisconsin Geological and Natural History Survey map showing extent of last glaciation
- Driftless Region Food and Farm Project
- Driftless Area Magazine