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Sjors Scheres
NationalityDutch
Alma mater
Scientific career
Institutions
Thesis Conditional Optimization: an N-particle approach to protein structure refinement (2003)
Doctoral advisor Piet Gros
Website www2.mrc-lmb.cam.ac.uk/group-leaders/n-to-s/sjors-scheres/

Sjors Hendrik Willem Scheres FRS (born 1975) is a Dutch scientist at the MRC Laboratory of Molecular Biology Cambridge, UK. [1] [2]

Education

Scheres studied Chemistry at Utrecht University in The Netherlands, and spent nine months at the European Synchrotron Radiation Facility in France for his undergraduate research thesis. He then came back to Utrecht University for his DPhil in Protein Crystallography, [3] which was supervised by Piet Gros.

Career

Scheres worked as a Postdoctoral researcher at the Spanish National Center for Biotechnology (CNB) with José Maria Carazo from 2003-2010, where he developed classification algorithms for Cryogenic electron microscopy (cryo-EM) images based on Maximum likelihood estimation. [4] In 2010 Scheres was appointed as a group leader at the MRC Laboratory of Molecular Biology, Cambridge. There, he extended his maximum-likelihood methods to a general Empirical Bayes method for Protein structure determination by cryo-EM, [5] which he implemented in the computer program RELION. [6] In 2020, Scheres and collaborators used RELION to reach atomic resolution for a cryo-EM reconstruction of apo- Ferritin. [7]

Besides developing algorithms for cryo-EM image processing, Scheres has also collaborated with experimental groups to solve important protein structures. For example, Xiaochen Bai, currently at UTSW, in his group solved the structure of human Gamma secretase [8] in a collaboration with Shi Yigong. Since 2016, Scheres has worked closely together with Michel Goedert, who is also at the MRC Laboratory of Molecular Biology. Using cryo-EM image processing methods that were developed by Scheres, they solved the structure of Amyloid fibrils of Tau protein from the brain of an individual with Alzheimer's disease. [9] Since then, Scheres and Goedert have also solved the cryo-EM structures of tau filaments from multiple other Tauopathies, [10] as well as filaments of Amyloid beta from Alzheimer's disease, [11] Alpha-synuclein from Multiple system atrophy [12] and TMEM106B. [13]

Scheres has been a member of the Board of Reviewing Editors for eLife since 2014. [14] He has been joint Head of the Division of Structural Studies of the MRC Laboratory of Molecular Biology since 2018. [15] In 2021, he was elected a Fellow of the Royal Society. [16] In 2022, he was elected a foreign member of the Royal Netherlands Academy of Arts and Sciences. [17]

Awards

References

  1. ^ "Sjors Scheres - Google Scholar Citations". scholar.google.com. Retrieved 2018-07-31.
  2. ^ "Sjors Scheres - MRC Laboratory of Molecular Biology". MRC Laboratory of Molecular Biology. Retrieved 2018-07-31.
  3. ^ Scheres SH (2003). Conditional Optimization: An N-particle formalism for protein structure refinement (Thesis).
  4. ^ Scheres SH, Gao H, Valle M, Herman GT, Eggermont PP, Frank J, Carazo JM (2007). "Disentangling Conformational States of Macromolecules in 3D-EM through Likelihood Optimization". Nature Methods. 4 (1): 27–29. doi: 10.1038/nmeth992. PMID  17179934. S2CID  20967953.
  5. ^ Scheres SH (2012). "A Bayesian view on cryo-EM structure determination". J. Mol. Biol. 415 (2): 406–18. doi: 10.1016/j.jmb.2011.11.010. PMC  3314964. PMID  22100448.
  6. ^ Scheres SH (2012). "RELION: implementation of a Bayesian approach to cryo-EM structure determination". J. Struct. Biol. 180 (3): 519–30. doi: 10.1016/j.jsb.2012.09.006. PMC  3690530. PMID  23000701.
  7. ^ Nakane T, Kotecha A, Sente A, McMullan G, Masiulis S, Brown PM, Grigoras IT, Malinauskaite L, Malinauskas T, Miehling J, Uchanski T, Yu L, Karia D, Pechnikova EV, de Jong E, Keizer J, Bischoff M, McCormack J, Tiemeijer P, Hardwick SW, Chirgadze DY, Murshudov G, Aricescu AR, Scheres SH (2020). "Single-particle cryo-EM at atomic resolution". Nature. 587 (7832): 152–156. Bibcode: 2020Natur.587..152N. doi: 10.1038/s41586-020-2829-0. PMC  7611073. PMID  33087931.
  8. ^ Bai XC, Yan C, Yang G, Lu P, Ma D, Sun L, Zhou R, Scheres SH, Shi Y (2015). "An atomic structure of human gamma-secretase". Nature. 525 (7568): 212–17. Bibcode: 2015Natur.525..212B. doi: 10.1038/nature14892. PMC  4568306. PMID  26280335.
  9. ^ Fitzpatrick AW, Falcon B, He S, Murzin AG, Murshudov G, Garringer HJ, Crowther RA, Ghetti B, Goedert M, Scheres SH (2017). "Cryo-EM structures of tau filaments from Alzheimer's disease". Nature. 547 (7662): 185–90. Bibcode: 2017Natur.547..185F. doi: 10.1038/nature23002. PMC  5552202. PMID  28678775.
  10. ^ Shi Y, Zhang W, Yang Y, Murzin AG, Falcon B, Kotecha A, van Beers M, Tarutani A, Kametani F, Garringer HJ, Vidal R, Hallinan GI, Lashley T, Saito Y, Murayama S, Yoshida M, Tanaka H, Kakita A, Ikeuchi T, Robinson AC, Mann DM, Kovacs GG, Revesz T, Ghetti B, Hasegawa M, Goedert M, Scheres SH (2021). "Structure-based classification of tauopathies". Nature. 598 (7880): 359–363. Bibcode: 2021Natur.598..359S. doi: 10.1038/s41586-021-03911-7. PMC  7611841. PMID  34588692.
  11. ^ Yang Y, Arseni D, Zhang W, Huang M, Lovestam S, Schweighauser M, Kotecha A, Murzin AG, Peak-Chew SY, Macdonald J, Lavenir I, Garringer HJ, Gelpi E, Newell KL, Kovacs GG, Vidal R, Ghetti B, Falcon B, Scheres SH, Goedert M (2022). "Cryo-EM Structures of Amyloid-beta 42 Filaments from Human Brain". Science. 375 (6577): 167–172. Bibcode: 2022Sci...375..167Y. doi: 10.1126/science.abm7285. PMC  7612234. PMID  35025654.
  12. ^ Schweighauser M, Shi Y, Tarutani A, Kametani F, Murzin AG, Ghetti B, Matsubara T, Tomita T, Ando T, Hasegawa K, Murayama S, Yoshida M, Hasegawa M, Scheres SH, Goedert M (2020). "Structures of alpha-synuclein filaments from multiple system atrophy". Nature. 585 (7825): 464–469. Bibcode: 2020Natur.585..464S. doi: 10.1038/s41586-020-2317-6. PMC  7116528. PMID  32461689.
  13. ^ Schweighauser M, Arseni D, Huang M, Lovestam S, Shi Y, Yang Y, Zhang W, Kotecha A, Garringer HJ, Vidal R, Hallinan GI, Newell KL, Tarutani A, Murayama S, Miyazaki M, Saito Y, Yoshida M, Hasegawa K, Lashley T, Revesz T, Kovacs GG, van Swieten J, Takao M, Hasegawa M, Ghetti B, Falcon B, Murzin AG, Goedert M, Scheres SH (2022). "Age-dependent formation of TMEM106B amyloid filaments in human brain". Nature. 605 (7909): 310–314. Bibcode: 2022Natur.605..310S. doi: 10.1038/s41586-022-04650-z. PMC  9095482. PMID  35344985.
  14. ^ "Editors for Structural Biology and Molecular Biophysics". eLife. Retrieved 2018-07-31.
  15. ^ "Structural Studies - MRC Laboratory of Molecular Biolog". mrc-lmb.cam.ac.uk. Retrieved 2022-04-15.
  16. ^ "Sjors Scheres | Royal Society". royalsociety.org. Retrieved 2021-05-16.
  17. ^ "Sjors Scheres" (in Dutch). Royal Netherlands Academy of Arts and Sciences. Retrieved 10 December 2023.
  18. ^ "Sjors Scheres is awarded the Bijvoet Medal - MRC Laboratory of Molecular Biology". MRC Laboratory of Molecular Biology. 2018-04-27. Retrieved 2018-07-31.
  19. ^ "Sjors Scheres elected to EMBO membership - MRC Laboratory of Molecular Biology". MRC Laboratory of Molecular Biology. 2017-06-16. Retrieved 2018-07-31.
  20. ^ "Winners KNCV Gouden Medaille - KNCV English". en.kncv.nl. Retrieved 2018-07-31.
  21. ^ Callaway E (2014). "365 days: Nature's 10". Nature. 516 (7531): 311–19. Bibcode: 2014Natur.516..311.. doi: 10.1038/516311a. PMID  25519114.
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