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Sim4Life
Developer(s)ZMT Zurich MedTech AG
Stable release
V8.0 / March 14, 2024; 2 months ago (2024-03-14)
TypeComputer-aided design
Website sim4life.swiss

Sim4Life (V8.0 Web and Desktop) is a computational simulation platform developed by the Foundation for Research on Information Technologies in Society (IT'IS) with funding from Innosuisse (formerly known as CTI), [1] [2] a Swiss federal funding instrument. The platform combines classical technical computer-aided-design tools with multi-physics solvers, computational human phantoms, medical-image-based modeling, and physiological tissue models. Sim4Life is marketed by IT'IS partner ZMT Zurich MedTech AG (ZMT). The platform is used in personalized medicine applications for optimization of treatments involving medical devices [3] [4] and the safety of magnetic resonance imaging [5] [6] [7]. Sim4Life has also been used by medical researchers to study non-invasive methods of brain stimulation [8] [9] and transcranial focused ultrasound. [10] [11] S4Llite is an online version of Sim4Life that is free-of-charge for students for team-learning and online collaboration with classmates and teachers on limited size projects.

S4Llite
Developer(s)ZMT Zurich MedTech AG
TypeComputer-aided design
Website sim4life.swiss/science

S4Llite and the online version of Sim4Life rely on open-source o²S²PARC [12] technologies, which were developed as part of the 'Stimulating Peripheral Activity to Relieve Conditions' (SPARC) [13] program of the National Institutes of Health Common Fund to enable collaborative, reproducible, and sustainable computational neurosciences.

References

  1. ^ "Development of a Multiphysics Simulation Platform for Computational BioMed and Life Sciences (Sim4Life)". ARAMIS. 27 November 2014. Retrieved 17 March 2024.
  2. ^ "R and D project : S4L-CAPITALIS - Extension of the Sim4Life Platform (S4L) for Analysis and Optimization of the Neurovascular and Neurological Devices and Treatments in the Head". ARAMIS. 1 June 2015. Retrieved 17 March 2024.
  3. ^ Rowald, Andreas; et al. (7 February 2022). "Activity-dependent spinal cord neuromodulation rapidly restores trunk and leg motor functions after complete paralysis". Nature Medicine. 28 (2): 260–271. doi: 10.1038/s41591-021-01663-5. PMID  35132264 – via Nature.
  4. ^ Beck, Marcus; Wust, Peter; Oberacker, Eva; Rattunde, Alexander; Päßler, Tom; Chrzon, Benjamin; Veltsista, Paraskevi Danai; Nadobny, Jacek; Pellicer, Ruben; Herz, Enrico; Winter, Lukas; Budach, Volker; Zschaeck, Sebastian; Ghadjar, Pirus (16 Mar 2022). "Experimental and computational evaluation of capacitive hyperthermia". International Journal of Hyperthermia. 39 (1): 504–516. doi: 10.1080/02656736.2022.2048093. PMID  35296213 – via Taylor & Francis Online.
  5. ^ De Buck, Matthijs H. S.; Jezzard, Peter; Jeong, Hongbae; Hess, Aaron T. (2021). "An investigation into the minimum number of tissue groups required for 7T in-silico parallel transmit electromagnetic safety simulations in the human head". Magnetic Resonance in Medicine. 85 (2): 1114–1122. doi: 10.1002/mrm.28467. PMID  32845034 – via Wiley Online Library.
  6. ^ Jeong, H.; Ntolkeras, G.; Alhilani, M.; Atefi, S. R.; Zöllei, L.; Fujimoto, K.; Pourvaziri, A.; Lev, M. H.; Grant, P. E.; Bonmassar, G. (13 January 2021). "Development, validation, and pilot MRI safety study of a high-resolution, open source, whole body pediatric numerical simulation model". PLOS ONE. 16 (1): e0241682. Bibcode: 2021PLoSO..1641682J. doi: 10.1371/journal.pone.0241682. PMC  7806143. PMID  33439896.
  7. ^ Meliadò, Ettore Flavio; Sbrizzi, Alessandro; Van Den Berg, Cornelis A. T.; Luijten, Peter R.; Raaijmakers, Alexander J. E. (2021). "Real-time assessment of potential peak local specific absorption rate value without phase monitoring: Trigonometric maximization method for worst-case local specific absorption rate determination". Magnetic Resonance in Medicine. 85 (6): 3420–3433. doi: 10.1002/mrm.28635. PMC  7986921. PMID  33350525.
  8. ^ Fiocchi, Serena; Chiaramello, Emma; Marrella, Alessandra; Bonato, Marta; Parazzini, Marta; Ravazzani, Paolo (23 September 2022). "Modelling of magnetoelectric nanoparticles for non-invasive brain stimulation: a computational study". Journal of Neural Engineering. 19 (5): 056020. Bibcode: 2022JNEng..19e6020F. doi: 10.1088/1741-2552/ac9085. PMID  36075197 – via IOP Publishing.
  9. ^ Gudvangen, Emily; Kim, Vitalii; Novickij, Vitalij; Battista, Federico; Pakhomov, Andrei G. (2 February 2022). "Electroporation and cell killing by milli- to nanosecond pulses and avoiding neuromuscular stimulation in cancer ablation". Scientific Reports. 12 (1): 1763. Bibcode: 2022NatSR..12.1763G. doi: 10.1038/s41598-022-04868-x. PMC  8811018. PMID  35110567.
  10. ^ Truong, D. Q.; Thomas, C.; Hampstead, B. M.; Datta, A. (February 3, 2022). "Comparison of Transcranial Focused Ultrasound and Transcranial Pulse Stimulation for Neuromodulation: A Computational Study". Neuromodulation: Technology at the Neural Interface. 25 (4): 606–613. doi: 10.1016/j.neurom.2021.12.012. PMID  35125300 – via Elsevier Inc.
  11. ^ Huang, Y.; Wen, P.; Song, B.; Li, Y. (August 2022). "Numerical investigation of the energy distribution of Low-intensity transcranial focused ultrasound neuromodulation for hippocampus". Ultrasonics. 124: 106724. doi: 10.1016/j.ultras.2022.106724. PMID  35299039. S2CID  247423819 – via Elsevier Science Direct.
  12. ^ Osanlouy, Mahyar; Bandrowski, Anita; De Bono, Bernard; Brooks, David; Cassarà, Antonino M.; Christie, Richard; Ebrahimi, Nazanin; Gillespie, Tom; Grethe, Jeffrey S.; Guercio, Leonardo A.; Heal, Maci; Lin, Mabelle; Kuster, Niels; Martone, Maryann E.; Neufeld, Esra; Nickerson, David P.; Soltani, Elias G.; Tappan, Susan; Wagenaar, Joost B.; Zhuang, Katie; Hunter, Peter J. (24 June 2021). "The SPARC DRC: Building a Resource for the Autonomic Nervous System Community". Frontiers in Physiology. 12: 693735. doi: 10.3389/fphys.2021.693735. PMC  8265045. PMID  34248680.
  13. ^ "The SPARC computational modeling platform o²S²PARC now powers ZMT's S4Llite". SPARC — bridging the body and the brain. 15 February 2023. Retrieved 17 March 2024.

External links[edit]

ZMT Zurich MedTech AG website

IT'IS Foundation website