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Therapy that uses a personalized cancer vaccine based on mRNA vaccine technology
Personalized mRNA cancer vaccine therapy is a therapy that uses a personalized
cancer vaccine based on
mRNA vaccine technology to target existing tumors in patients. As of 2024
[update] , number of mRNA cancer vaccines are in
clinical trials , of which many are
personalized therapies based on engineering mRNA-mediated immune response that targets the patient's particular strain of cancer cells.
[1]
Experimental treatments include treatments for
pancreatic cancer , head and neck cancers, and
melanoma .
[2]
[3]
[4]
In 2024, the British
National Health Service announced that had launched its
Cancer Vaccine Launch Pad , a collaboration for trials for the use of personalized mRNA cancer vaccines on its patients.
[5]
References
^ Yao, Ruhui; Xie, Chunyuan; Xia, Xiaojun (2024-12-31).
"Recent progress in mRNA cancer vaccines" . Human Vaccines & Immunotherapeutics . 20 (1).
doi :
10.1080/21645515.2024.2307187 .
ISSN
2164-5515 .
PMC
10826636 .
PMID
38282471 .
^ Kang, Ning; Zhang, Si; Wang, Yuzhuo (2023).
"A personalized mRNA vaccine has exhibited potential in the treatment of pancreatic cancer" . Holistic Integrative Oncology . 2 (1): 18.
doi :
10.1007/s44178-023-00042-z .
ISSN
2731-4529 .
PMC
10248956 .
PMID
37323470 .
^ Shibata, Hirofumi; Zhou, Liye; Xu, Na; Egloff, Ann Marie; Uppaluri, Ravindra (March 2021).
"Personalized cancer vaccination in head and neck cancer" . Cancer Science . 112 (3): 978–988.
doi :
10.1111/cas.14784 .
ISSN
1349-7006 .
PMC
7935792 .
PMID
33368875 .
^ Carvalho, Thiago (2023-08-16).
"Personalized anti-cancer vaccine combining mRNA and immunotherapy tested in melanoma trial" . Nature Medicine . 29 (10): 2379–2380.
doi :
10.1038/d41591-023-00072-0 .
PMID
37773210 .
^ Walsh, Fergus (2024-05-30).
"Thousands to trial personalised cancer vaccines" . BBC News . Retrieved 2024-06-01 .
External links