From Wikipedia, the free encyclopedia
Medical condition
Diffuse hemispheric glioma Other names DHG, G34-DHG, DHG-G34
Specialty Neuro-oncology Causes Unknown Treatment Temozolomide
Diffuse hemispheric glioma, H3G34 mutant (DHG) is a rare, high-grade, infiltrative
WHO grade 4 brain tumor most often found in adolescents and young adults.
[1]
[2] The majority are found in the
frontal ,
parietal , and
temporal lobes .
[3]
Diagnosis
Most diffuse hemispheric gliomas fell under the classification of
glioblastoma historically.
[2] However, they have different radiological presentations, including no or faint
contrast enhancement .
[3] A diagnosis can only be definitively made with genetic testing of the tumor.
[4]
Treatment
Diffuse hemispheric gliomas should be
resected , followed by
radiation therapy and
temozolomide .
[5]
Prognosis
Median time to progression is 10 months. After progression, the median time to death is 5 months. Non-pediatric patients and patients with near-or-gross total resection have increased survival duration.
[6]
Pathology
Diffuse hemispheric gliomas have a distinct mutation in the histone gene
H3F3A .
[6]
References
^ Picart, Thiébaud; Barritault, Marc; Poncet, Delphine; Berner, Lise-Prune; Izquierdo, Cristina; Tabouret, Emeline; Figarella-Branger, Dominique; Idbaïh, Ahmed; Bielle, Franck; Bourg, Véronique; Vandenbos, Fanny Burel; Moyal, Elizabeth Cohen-Jonathan; Uro-Coste, Emmanelle; Guyotat, Jacques; Honnorat, Jérôme (2021).
"Characteristics of diffuse hemispheric gliomas, H3 G34-mutant in adults" . Neuro-Oncology Advances . 3 (1): vdab061.
doi :
10.1093/noajnl/vdab061 .
ISSN
2632-2498 .
PMC
8156974 .
PMID
34056608 .
^
a
b Weller, Michael; van den Bent, Martin; Preusser, Matthias; Le Rhun, Emilie; Tonn, Jörg C.; Minniti, Giuseppe; Bendszus, Martin; Balana, Carmen; Chinot, Olivier; Dirven, Linda; French, Pim; Hegi, Monika E.; Jakola, Asgeir S.; Platten, Michael; Roth, Patrick (March 2021).
"EANO guidelines on the diagnosis and treatment of diffuse gliomas of adulthood" . Nature Reviews Clinical Oncology . 18 (3): 170–186.
doi :
10.1038/s41571-020-00447-z .
ISSN
1759-4782 .
PMC
7904519 .
PMID
33293629 .
^
a
b Shao, Hanbing; Gong, Jing; Su, Xiaorui; Chen, Ni; Li, Shuang; Yang, Xibiao; Zhang, Simin; Huang, Zhangfeng; Hu, Wei; Gong, Qiyong; Liu, Yaou; Yue, Qiang (2024-03-01).
"MRI characteristics of H3 G34-mutant diffuse hemispheric gliomas and possible differentiation from IDH-wild-type glioblastomas in adolescents and young adults" . Journal of Neurosurgery. Pediatrics . 33 (3): 236–244.
doi :
10.3171/2023.10.PEDS23235 .
ISSN
1933-0715 .
PMID
38157540 .
^ Antonelli, Manila; Poliani, Pietro Luigi (December 2022).
"Adult type diffuse gliomas in the new 2021 WHO Classification" . Pathologica . 114 (6): 397–409.
doi :
10.32074/1591-951X-823 .
ISSN
1591-951X .
PMC
9763975 .
PMID
36534419 .
^
"Diffuse hemispheric glioma, H3 G34 mutant" . www.pathologyoutlines.com . Retrieved 2024-04-03 .
^
a
b Kurokawa, Ryo; Baba, Akira; Kurokawa, Mariko; Pinarbasi, Emile S.; Makise, Naohiro; Ota, Yoshiaki; Kim, John; Srinivasan, Ashok; Moritani, Toshio (January 2022).
"Neuroimaging features of diffuse hemispheric glioma, H3 G34-mutant: A case series and systematic review" . Journal of Neuroimaging . 32 (1): 17–27.
doi :
10.1111/jon.12939 .
hdl :
2027.42/171545 .
ISSN
1051-2284 .
PMID
34632671 .
External links