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Delftia tsuruhatensis
Scientific classification Edit this classification
Domain: Bacteria
Phylum: Pseudomonadota
Class: Betaproteobacteria
Order: Burkholderiales
Family: Comamonadaceae
Genus: Delftia
Species:
D. tsuruhatensis
Binomial name
Delftia tsuruhatensis
Shigematsu et al. 2003, sp. nov. [1]
Type strain
ATCC BAA-554, DSM 17581, IFO 16741, NBRC 16741, T7 [2]

Delftia tsuruhatensis is a Gram-negative, rod-shaped, catalase- and oxidase-positive, motile bacterium from the Comamonadaceae family. It was first isolated from a wastewater treatment plant in Japan in 2003. [3] D. tsuruhatensis is an opportunistic and emergent pathogen. [4] All documented human infections are healthcare-associated. [4] [5] [6]

Biology and biochemistry

Cells are slightly curved, short rod-shaped cells that occur singly or in pairs. Cells are 0.7–1.2 μm wide and 2.4–4.0 μm long. [3]

D. tsuruhatensis can degrade phenolic compounds [7] and aniline, [8] which are often pollutants of soil and water.

Biofilm interactions

D. tsuruhatensis can inhibit quorum sensing and biofilm formation, which could inform new therapeutic drugs against antibiotic-resistant bacteria. [9] D. tsuruhatensis inhibits quorum sensing and suppresses biofilm formation against Pseudomonas aeruginosa and other pathogens. [9] [10] These activities increase P. aeruginosa's susceptibility to antibiotics by 2 to 3 times. [11]

Applications

In 2023, researchers published evidence in Science that D. tsuruhatensis prevents the development of malaria in mosquitos by secreting harmane. Mosquitos infected by the bacteria had 75% fewer Plasmodium oocysts and featured infection rates one third those of uninfected mosquitoes. [12] [13] [14] [15]

See also

  • Serratia – a genus of bacteria that can be genetically modified to prevent malaria.
  • Wolbachia – a genus of bacteria that can be used to control dengue.

References

  1. ^ "Genus Delftia". List of Prokaryotic Names with Standing in Nomenclature. Retrieved 17 December 2016.
  2. ^ "Strain Passport: NBRC 16741 Delftia tsuruhatensis". StrainInfo. Archived from the original on 28 May 2017. Retrieved 17 December 2016.
  3. ^ a b Shigematsu T, Yumihara K, Ueda Y, Numaguchi M, Morimura S, Kida K (2003). "Delftia tsuruhatensis sp. nov., a terephthalate-assimilating bacterium isolated from activated sludge". International Journal of Systematic and Evolutionary Microbiology. 53 (Pt 5): 1479–83. doi: 10.1099/ijs.0.02285-0. PMID  13130036.
  4. ^ a b Ranc, A; Dubourg, G; Fournier, PE; Raoult, D; Fenollar, F (March 2018). "Delftia tsuruhatensis, an Emergent Opportunistic Healthcare-Associated Pathogen". Emerging Infectious Diseases. 24 (3): 594–596. doi: 10.3201/eid2403.160939. PMC  5823324. PMID  29460754.
  5. ^ Tabak, Omur; Mete, Bilgul; Aydin, Selda; Mandel, Nil Molinas; Otlu, Baris; Ozaras, Resat; Tabak, Fehmi (2013). "Port-related Delftia tsuruhatensis bacteremia in a patient with breast cancer". The New Microbiologica. 36 (2): 199–201. ISSN  1121-7138. PMID  23686127.
  6. ^ Preiswerk, Benjamin; Ullrich, Silvia; Speich, Rudolf; Bloemberg, Guido V.; Hombach, Michael (2011). "Human infection with Delftia tsuruhatensis isolated from a central venous catheter". Journal of Medical Microbiology. 60 (2): 246–248. doi: 10.1099/jmm.0.021238-0. ISSN  0022-2615. PMID  20965913.
  7. ^ Juárez-Jiménez, Belén; Manzanera, Maximino; Rodelas, Belén; Martínez-Toledo, Maria Victoria; Gonzalez-López, Jesus; Crognale, Silvia; Pesciaroli, Chiara; Fenice, Massimiliano (2010-06-01). "Metabolic characterization of a strain (BM90) of Delftia tsuruhatensis showing highly diversified capacity to degrade low molecular weight phenols". Biodegradation. 21 (3): 475–489. doi: 10.1007/s10532-009-9317-4. ISSN  1572-9729. PMID  19946734. S2CID  2130491.
  8. ^ Sheludchenko, M. S.; Kolomytseva, M. P.; Travkin, V. M.; Akimov, V. N.; Golovleva, L. A. (2005-09-01). "Degradation of Aniline by Delftia tsuruhatensis 14S in Batch and Continuous Processes". Applied Biochemistry and Microbiology. 41 (5): 465–468. doi: 10.1007/s10438-005-0083-8. ISSN  1608-3024. PMID  16240651. S2CID  20548636.
  9. ^ a b Malešević, Milka; Di Lorenzo, Flaviana; Filipić, Brankica; Stanisavljević, Nemanja; Novović, Katarina; Senerovic, Lidija; Polović, Natalija; Molinaro, Antonio; Kojić, Milan; Jovčić, Branko (2019-11-11). "Pseudomonas aeruginosa quorum sensing inhibition by clinical isolate Delftia tsuruhatensis 11304: involvement of N-octadecanoylhomoserine lactones". Scientific Reports. 9 (1): 16465. Bibcode: 2019NatSR...916465M. doi: 10.1038/s41598-019-52955-3. ISSN  2045-2322. PMC  6848482. PMID  31712724.
  10. ^ Singh, Vijay K.; Mishra, Avinash; Jha, Bhavanath (2017). "Anti-quorum Sensing and Anti-biofilm Activity of Delftia tsuruhatensis Extract by Attenuating the Quorum Sensing-Controlled Virulence Factor Production in Pseudomonas aeruginosa". Frontiers in Cellular and Infection Microbiology. 7: 337. doi: 10.3389/fcimb.2017.00337. ISSN  2235-2988. PMC  5526841. PMID  28798903.
  11. ^ Hentzer, M. (2003-08-01). "Attenuation of Pseudomonas aeruginosa virulence by quorum sensing inhibitors". The EMBO Journal. 22 (15): 3803–3815. doi: 10.1093/emboj/cdg366. ISSN  1460-2075. PMC  169039. PMID  12881415.
  12. ^ OFFORD, CATHERINE (3 Aug 2023). "Microbe Stops Mosquitoes Harboring Malaria Parasite".
  13. ^ Huang, Wei; Rodrigues, Janneth; Bilgo, Etienne; Tormo, José R.; Challenger, Joseph D.; De Cozar-Gallardo, Cristina; Pérez-Victoria, Ignacio; Reyes, Fernando; Castañeda-Casado, Pablo; Gnambani, Edounou Jacques; Hien, Domonbabele François de Sales; Konkobo, Maurice; Urones, Beatriz; Coppens, Isabelle; Mendoza-Losana, Alfonso (2023-08-04). "Delftia tsuruhatensis TC1 symbiont suppresses malaria transmission by anopheline mosquitoes". Science. 381 (6657): 533–540. doi: 10.1126/science.adf8141. hdl: 10044/1/105278. ISSN  0036-8075. PMID  37535741. S2CID  260440907.
  14. ^ Offord, Catherine (3 August 2023). "Microbe stops mosquitoes from harboring malaria parasite". Science.
  15. ^ "Chance discovery helps fight against malaria". BBC News. 2023-08-04. Retrieved 2023-08-04.

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